Abstract:Background:
Recently, several genome-wide association studies have demonstrated a cumulative association of 17q24 rs1859962 gene variants with prostate cancer (PCa) risk, but conflicting results on this issue have been reported. Hence, we performed a systematic literature review and meta-analysis to assess the association between 17q24 rs1859962 gene and PCa risk.
Methods:
Systematic literature searches were conducted with PubMed, EMBASE, Science Direct… Show more
“…PC susceptibility locus at 17q24 has also been pinpointed as another risk loci. In a recent meta-analysis of association of the variant rs1859962 with the risk of PC development, the authors found the rs1859962 [G] allele to be significantly associated with the risk of PC (77). The variant rs1859962 has been mapped to enhancer elements of these variants in a diverse racial and ethnic population by validation studies is much needed before risk loci can be utilized in PC risk modeling.…”
Section: Challenges and Future Perspectivementioning
“…PC susceptibility locus at 17q24 has also been pinpointed as another risk loci. In a recent meta-analysis of association of the variant rs1859962 with the risk of PC development, the authors found the rs1859962 [G] allele to be significantly associated with the risk of PC (77). The variant rs1859962 has been mapped to enhancer elements of these variants in a diverse racial and ethnic population by validation studies is much needed before risk loci can be utilized in PC risk modeling.…”
Section: Challenges and Future Perspectivementioning
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