Association of 14‐bp insertion/deletion polymorphism of HLA‐G gene with unexplained recurrent spontaneous abortion: a meta‐analysis

Abstract

A meta-analysis was performed to assess the association of the human leukocyte antigen-G (HLA-G) 14 bp insertion (ins)/deletion (del) polymorphism with unexplained recurrent spontaneous abortions (URSA). The fixed or random effect pooled measure was selected based on the homogeneity test among studies that was evaluated with I². Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. In this meta-analysis, 14 studies with 1464 cases and 1247 controls corresponded to the inclusion criteria were included. Significant associations between 14 bp ins/del polymorphism and risk of URSA were observed in both dominant [random effect model (REM) OR = 1.469, 95% CI = 1.127-1.914] and codominant (REM OR = 1.195, 95% CI = 1.005-1.420) models. After excluding two articles that deviated from Hardy-Weinberg equilibrium in cases and sensitivity analysis, significant associations were also observed in dominant [fixed effect model (FEM) OR = 1.224, 95% CI = 1.020-1.470] and codominant (FEM OR = 1.158, 95% CI = 1.028-1.305) models. This meta-analysis suggests that the 14 bp ins HLA-G allele is associated with increased risk of URSA. The results are of importance to the clinical practice of URSA and infertility.

Relationship between HLA-G polymorphism and susceptibility to recurrent miscarriage: A meta-analysis of non-family-based studies

“…Our meta-analysis results were different from the outcomes of the previous metaanalysis of Wang et al 2013 [23]. After adding the study of ).…”

“…But the results were controversial or inconclusive, partly because each study involved few cases and few controls and, therefore, there was not enough information to demonstrate such association. In a recent meta-analysis article of Wang et al(2013), it was suggested that the 14 bp ins HLA-G allele was associated with increased risk of RM [23]. The studies of Christiansen et al 2012 which were included in the metaanalysis of Wang et al(2013) were from the same study group.…”

“…In a recent meta-analysis article of Wang et al(2013), it was suggested that the 14 bp ins HLA-G allele was associated with increased risk of RM [23]. The studies of Christiansen et al 2012 which were included in the metaanalysis of Wang et al(2013) were from the same study group. When there were multiple publications from the same study group, the most informative and recent study was included for review [24].…”

“…When there were multiple publications from the same study group, the most informative and recent study was included for review [24]. Moreover, three studies of Akhter A et al 2012 [25], Kano T et al 2007[26] and Liu YD et al 2008[27] which reported the association of HLA-G 14-bp polymorphism and RM susceptibility did not be included in the meta-analysis article of Wang et al,(2013) . Therefore it was necessary to reevaluate the association of HLA-G 14-bp polymorphism and RM susceptibility, by excluding the study of and including the studies of Akhter A et al 2012, Kano T et al 2007 andLiu YD et al 2008.…”

DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS

“…Другой путь формирования ВПС, ассоциированный с HLA-G, может быть связан с активацией вертикального пути пере-дачи вирусов от матерей к плоду. Показано, что ВИЧ и цитомегаловирус достоверно чаще пере-даются от инфицированных матерей к их детям при наличии у матерей аллелей или генотипов с HLA-G 3'UTR 14-bp ins [21]. Известно, что гер-петические вирусы индуцируют формирование ВПС.…”