Association of 14-3-3 ε gene haplotype with completed suicide in Japanese

Yanagi, Masaya; Sato, Osamu; Kitamura, Noboru; Okamura, Kenji; Sakurai, Kazuo; Nishiguchi, Naoki; Hashimoto, Takeshi; Nushida, Hideyuki; Ueno, Yoshio; Kanbe, Daiji; Kawamura, Minoru; Araki, Kazuo; Nawa, Hiroyuki; Maeda, Kiyoshi

doi:10.1007/s10038-005-0241-0

Cited by 40 publications

(23 citation statements)

References 40 publications

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“…Third, seven of the genes on the alarm pheromone list are located within previously identified quantitative trait loci for AHB aggression, as are 12 from the AHB list (21) ( Table S3). Among them, 14-3-3 , a gene up-regulated in the brains of human suicide victims (22), was up-regulated in AHB soldier brains in this study and also in a relatively aggressive EHB strain (21). These and other genes that appear on one or more of our gene lists are good candidates for effectors of honey bee aggression.…”

Section: Common Brain Transcriptional Network Associated With Inherimentioning

confidence: 52%

Honey bee aggression supports a link between gene regulation and behavioral evolution

Alaux

Sinha²,

Hasadsri

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

243

387

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A prominent theory states that animal phenotypes arise by evolutionary changes in gene regulation, but the extent to which this theory holds true for behavioral evolution is not known. Because ''nature and nurture'' are now understood to involve hereditary and environmental influences on gene expression, we studied whether environmental influences on a behavioral phenotype, i.e., aggression, could have evolved into inherited differences via changes in gene expression. Here, with microarray analysis of honey bees, we show that aggression-related genes with inherited patterns of brain expression are also environmentally regulated. There were expression differences in the brain for hundreds of genes between the highly aggressive Africanized honey bee compared with European honey bee (EHB) subspecies. Similar results were obtained for EHB in response to exposure to alarm pheromone (which provokes aggression) and when comparing old and young bees (aggressive tendencies increase with age). There was significant overlap of the gene lists generated from these three microarray experiments. Moreover, there was statistical enrichment of several of the same cis regulatory motifs in promoters of genes on all three gene lists. Aggression shows a remarkably robust brain molecular signature regardless of whether it occurs because of inherited, age-related, or environmental (social) factors. It appears that one element in the evolution of different degrees of aggressive behavior in honey bees involved changes in regulation of genes that mediate the response to alarm pheromone.

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Section: Common Brain Transcriptional Network Associated With Inherimentioning

confidence: 52%

Honey bee aggression supports a link between gene regulation and behavioral evolution

Alaux

Sinha²,

Hasadsri

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

243

387

View full text Add to dashboard Cite

show abstract

“…189 The possible involvement of 14-3-3 epsilon, which is related to neurogenesis, was identified as possible candidate gene, as it was upregulated using DNA microarrays with brains of suicide victims. 190 These authors investigated several SNPs within this gene and found a haplotype associated with completed suicide thus suggesting that a dysregulation of neurogenesis might be involved in suicide. 190 This latter study clearly eliminated the possibility that microarray analysis provides the opportunity to study thousands of genes at once and may thus give a 'snapshot' about the brain gene activity before completing suicide.…”

Section: Search For New Candidate Genes and Miscellaneous Resultsmentioning

confidence: 99%

“…190 These authors investigated several SNPs within this gene and found a haplotype associated with completed suicide thus suggesting that a dysregulation of neurogenesis might be involved in suicide. 190 This latter study clearly eliminated the possibility that microarray analysis provides the opportunity to study thousands of genes at once and may thus give a 'snapshot' about the brain gene activity before completing suicide. 191 Thus, microarray analysis is especially useful to identify new candidate genes and to gain new insight into the biological mechanism of suicide beyond the serotonergic system.…”

Section: Search For New Candidate Genes and Miscellaneous Resultsmentioning

confidence: 99%

Genetics of suicide

2006

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The concept that genetic factors contribute to the complex trait of suicidal behaviour has stimulated much work aimed at identifying susceptibility genes. So far molecular genetic studies focused on the serotonergic pathway as the intent to die and the lethality of suicide acts were related to the serotonergic system. Two genes have so far emerged as being involved in the vulnerability for suicidality: first, the intronic polymorphisms (A218C or A779C) of the tryptophan hydroxylase 1 (TPH1) gene, which was suggested as a quantitative risk factor for suicidal behaviour; second, the insertion/deletion polymorphism of the serotonin transporter gene (5-HTTLPR), which does not seem to be involved in general suicidal behaviour, but in violent and repeated suicide attempts. The data have further shown that the MAOA gene, which is consistently associated with impulsive-aggressive personality traits, is not related to suicide but might induce violent methods in subjects with other suicide risk factors. Predominantly negative were the findings with any type of the serotonin receptors and inconsistent with catecholamine-synthesizing and -metabolizing enzymes or with the dopaminergic receptors. This paper reviews the status of current knowledge in this area, points to the weakness of the investigations and presents new approaches beyond the serotonergic system.

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“…In comparison with microarray studies of schizophrenia and bipolar disorder, only a handful of studies have been reported on gene expression changes associated with major depression and completed suicide. [8][9][10] There is a clear need for further investigation of the gene expression changes associated with these phenotypes to gain better insight into their possible biological mechanisms. 11 We have carried out a microarray-based investigation of these brain regions in both depressed and nondepressed suicide victims in comparison with controls, to identify novel candidate systems and biological pathways that may be involved in suicide and major depression.…”

Section: Introductionmentioning

confidence: 99%

Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression

et al. 2007

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The prefrontal cortex is believed to play a major role in depression and suicidal behavior through regulation of cognition, memory, recognition of emotion, and anxiety-like states, with numerous post-mortem studies documenting a prefrontal serotonergic dysregulation considered to be characteristic of depressive psychopathology. This study was carried out to detect changes in gene expression associated with both suicide and major depression using oligonucleotide microarrays (Affymetrix HG-U133 chip set) summarizing expression patterns in primarily ventral regions of the prefrontal cortex (BA44, 45, 46 and 47). A total of 37 male subjects were included in this study, of which 24 were suicides (depressed suicides = 16, nondepressed suicides = 8) and 13 were matched controls. All subjects were clinically characterized by means of psychological autopsies using structured interviews. Unique patterns of differential expression were validated in each of the cortical regions evaluated, with group-specific changes highlighting the involvement of several key neurobiological pathways that have been implicated in both suicide and depression. An overrepresentation of factors involved in cell cycle control and cell division (BA44), transcription (BA44 and 47) and myelination (BA46) was seen in gene ontology analysis of differentially expressed genes, which also highlights changes in the expression of genes involved in ATP biosynthesis and utilization across all areas. Gene misexpression in BA46 was most pronounced between the two suicide groups, with many significant genes involved in GABAergic neurotransmission. The pronounced misexpression of genes central to GABAergic signaling and astrocyte/ oligodendrocyte function provides further support for a central glial pathology in depression and suicidal behavior.

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Association of 14-3-3 ε gene haplotype with completed suicide in Japanese

Cited by 40 publications

References 40 publications

Honey bee aggression supports a link between gene regulation and behavioral evolution

Honey bee aggression supports a link between gene regulation and behavioral evolution

Genetics of suicide

Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression

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