Association of 1-Year Blood Pressure Variability With Long-term Mortality Among Adults With Coronary Artery Disease

Abstract

Key Points Question Is short-term blood pressure variability from one physician office visit to the next (hereafter referred to as visit-to-visit blood pressure variability) associated with increased long-term mortality risk? Findings In this cohort study, 16 688 patients with hypertension who were 50 years of age or older with coronary artery disease were followed up for a mean of 10.9 years. When comparing quintiles of systolic blood pressure variability measures, higher quintiles were associated with long-term mortality even after adjusting for baseline demographic characteristics, mean blood pressure, and comorbidities; the signal was stronger in women compared with men. Meaning These findings support efforts to identify and minimize visit-to-visit blood pressure variability to potentially reduce excess mortality later in life.

Association Between Systolic Blood Pressure Variability and Major Adverse Cardiovascular Events in Korean Patients With Chronic Kidney Disease: Findings From KNOW‐CKD

“…There has been emerging evidence that visit‐to‐visit BP variability is an independent risk factor for the development of incident CKD, cardiovascular events, and death. 13 , 14 , 15 Similar issues on BP variability have also been studied in patients with CKD, but the results have been inconsistent. 16 , 17 , 18 , 19 , 20 Notably, many patients with CKD show high BP fluctuation, and optimal BP control is difficult to achieve as kidney failure worsens.…”

Feasibility and efficacy of a nurse practitioner-and pharmacist-led hypertension clinic

“…Furthermore, our results support a narrowing of range in BP for patients seen in this clinic. This has positive implications for patients as variability in BP has been linked to increase mortality in certain patient populations such as coronary artery disease (Dasa et al, 2021).…”

Bidirectional association between SBP variability and arterial stiffness in patients with chronic kidney disease: findings from KNOW-CKD study

“…Two additional definitions of VVSV were used for sensitivity analyses: the coefficient of variation (CoV) and average real variability (ARV), which were calculated using the following formulas [19].…”