Association maladie cœliaque et thrombose veineuse cérébrale. Revue de deux observations

Boucelma, M.

doi:10.1016/j.revmed.2012.03.160

“…There are eleven published cases of such association in the literature. In three cases [11][12][13], hyperhomocysteinemia prompted an ischemic stroke before a diagnosis of CD was made, whereas in one case, hyperhomocysteinemia provoked cerebral venous thrombosis in a patient with untreated CD [14].…”

Section: Discussionmentioning

confidence: 99%

“…The rst reported case describing protein S and C de ciency-induced thrombosis in CD was published by Ghannouchi et al [15], where a patient had intracardiac thrombosis presenting with an ischemic stroke. Protein S de ciency is associated with other unusual locations of thrombosis, such as cerebral venous thrombosis [16,14], the hepatic veins, deep veins of the lower extremities, and the superior mesenteric artery [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease - A case report and literature review

Alhosain

¹

,

Kouba

²

2020

Preprint

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Background: Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease.Case Presentation: A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease.Conclusions: Celiac disease has a wide range of intestinal and extra-intestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

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“…A brief description of published cases reporting such association in the literature is summarized in Table 1 [9][10][11][12][13][14][15][16][17][18][19].…”

Section: A) Malabsorption-induced Vitamin De Ciencymentioning

confidence: 99%

“…In three cases [9][10][11], hyperhomocysteinemia prompted an ischemic stroke before a diagnosis of CD was made, whereas in one case, hyperhomocysteinemia provoked cerebral venous thrombosis in a patient with untreated CD [12].…”

Section: A) Malabsorption-induced Vitamin De Ciencymentioning

confidence: 99%

“…The rst reported case describing protein S and C de ciency-induced thrombosis in CD was published by Ghannouchi et al [13], where a patient had intracardiac thrombosis presenting with an ischemic stroke. Protein S de ciency is associated with other unusual locations of thrombosis, such as cerebral venous thrombosis [12,14], the hepatic veins, deep veins of the lower extremities, and the superior mesenteric artery [15][16][17].…”

Section: A) Malabsorption-induced Vitamin De Ciencymentioning

confidence: 99%

See 1 more Smart Citation

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease - A case report and literature review

Alhosain

¹

,

Kouba

²

2020

Preprint

0

View full text Add to dashboard Cite

Background: Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease.Case Presentation: A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease.Conclusions: Celiac disease has a wide range of intestinal and extra-intestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

show abstract

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

Alhosain

¹

,

Kouba

²

2020

View full text Add to dashboard Cite

Background Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease. Case presentation A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease. Conclusions Celiac disease has a wide range of intestinal and extraintestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

show abstract

Association maladie cœliaque et thrombose veineuse cérébrale. Revue de deux observations

Cited by 3 publications

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Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease - A case report and literature review

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease - A case report and literature review

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease - A case report and literature review

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

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