Association maladie cœliaque et thrombose veineuse cérébrale. Revue de deux observations

Boucelma, M.; Saadi, Mohammed; Boukrara, H.; Bensalah, D.; Hakem, D.; Berrah, A.

doi:10.1016/j.jmv.2012.11.003

Cited by 9 publications

(9 citation statements)

References 15 publications

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“…Thrombotic events are increased in CD[ 36 ], can be recurrent[ 37 ], and may be present at multiple locations[ 38 ] which are observable via Doppler ultrasonographic examination[ 39 ]. Thrombophilia may result from hyperhomocysteinemia and deficiencies in protein S, folate, and vitamin B2[ 40 - 42 ].…”

Section: Publication Summary Statisticsmentioning

confidence: 99%

Cardiovascular involvement in celiac disease

et al. 2017

WJC

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Celiac disease (CD) is an autoimmune response to ingestion of gluten protein, which is found in wheat, rye, and barley grains, and results in both small intestinal manifestations, including villous atrophy, as well as systemic manifestations. The main treatment for the disease is a gluten-free diet (GFD), which typically results in the restoration of the small intestinal villi, and restoration of other affected organ systems, to their normal functioning. In an increasing number of recently published studies, there has been great interest in the occurrence of alterations in the cardiovascular system in untreated CD. Herein, published studies in which CD and cardiovascular terms appear in the title of the study were reviewed. The publications were categorized into one of several types: (1) articles (including cohort and case-control studies); (2) reviews and meta-analyses; (3) case studies (one to three patient reports); (4) letters; (5) editorials; and (6) abstracts (used when no full-length work had been published). The studies were subdivided as either heart or vascular studies, and were further characterized by the particular condition that was evident in conjunction with CD. Publication information was determined using the Google Scholar search tool. For each publication, its type and year of publication were tabulated. Salient information from each article was then compiled. It was determined that there has been a sharp increase in the number of CD - cardiovascular studies since 2000. Most of the publications are either of the type “article” or “case study”. The largest number of documents published concerned CD in conjunction with cardiomyopathy (33 studies), and there have also been substantial numbers of studies published on CD and thrombosis (27), cardiovascular risk (17), atherosclerosis (13), stroke (12), arterial function (11), and ischemic heart disease (11). Based on the published research, it can be concluded that many types of cardiovascular issues can occur in untreated CD patients, but that most tend to resolve on a GFD, often in conjunction with the healing of small intestinal villous atrophy. However, in some cases the alterations are irreversible, underscoring the need for CD screening and treatment when cardiovascular issues arise of unknown etiology.

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Section: Publication Summary Statisticsmentioning

confidence: 99%

Cardiovascular involvement in celiac disease

et al. 2017

WJC

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“…et al Protein C and S deficiency, Hyperhomocysteinemia and anti B2 glycoprotein antibodies Peripheral veins, descending aorta, portal and splenic veins 7 cases Female ( n = 6), Male ( n = 1) [ 16 ] 2013 Boucelama. et al Hyperhomocysteinemia and Antiphospholipid antibodes, protein S deficiency SVT 2 cases Female ( n = 2) 63, 19 [ 17 ] 2013 Ghannouchi. et al Protein S and C deficiency Intracardiac thrombosis 1 case Male, 32 [ 2 ] 2016 Wassim.…”

Section: Discussionmentioning

confidence: 99%

“…In three cases [ 8 , 12 , 15 ], hyperhomocysteinemia prompted an ischemic stroke before a diagnosis of CD was made, whereas in one case, hyperhomocysteinemia provoked cerebral venous thrombosis in a patient with untreated CD [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The first reported case describing protein S and C deficiency-induced thrombosis in CD was published by Ghannouchi et al [ 2 ], where a patient had intracardiac thrombosis presenting with an ischemic stroke. Protein S deficiency is associated with other unusual locations of thrombosis, such as cerebral venous thrombosis [ 10 , 17 ], the hepatic veins, deep veins of the lower extremities, and the superior mesenteric artery [ 11 , 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

Alhosain

Kouba

2020

BMC Gastroenterol

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Background Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease. Case presentation A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease. Conclusions Celiac disease has a wide range of intestinal and extraintestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

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“…Les veines sus-hépatiques représentent la localisation la plus fréquente [2,[7][8][9], suivie par l'atteinte du tronc porte [4,10,11]. Plus rarement, des thrombophlébites cérébrales ont été rapportées [12,13], ainsi que des localisations aux membres inférieurs [14]. Les thromboses artérielles sont exceptionnelles, représentées par de rares cas d'AVC ischémiques [15][16][17][18].…”

Section: Observationunclassified