Association fibers connecting the Broca center and the lateral superior frontal gyrus: a microsurgical and tractographic anatomy

Kinoshita, Masashi; Shinohara, Harumichi; Hori, Osamu; Ozaki, Noriyuki; Ueda, Fumiaki; Nakada, Mitsutoshi; Hamada, Jun-ichiro; Hayashi, Yutaka

doi:10.3171/2011.10.jns11434

Cited by 51 publications

(38 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, we found a significant Group by Side interaction due to the reduction of mean FA on the left compared to the right FAT in AD patients. This is in contrast with previous observations of FAT being thicker in the left hemisphere of right-handed individuals [15], consistently with its association with languages processes [12,18,37]. It is remarkable that the observed microstructural damages were, likely, independent from a partial-volume effect.…”

Section: Discussioncontrasting

confidence: 56%

“…The aim of the present study was to assess the role played by FAT, an associative bundle involved in language's processes as spontaneous speech, speech fluency and speech initiation [15,37] in AD pathophysiology. The role of FAT has been previously investigated in patients showing languages disorders due to different conditions, such as neurodegenerative disorders (e.g.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Damage to the Frontal Aslant Tract Accounts for Visuo-Constructive Deficits in Alzheimer’s Disease

Serra

Gabrielli

Tuzzi

et al. 2017

JAD

View full text Add to dashboard Cite

The Frontal Aslant Tract (FAT) has been described as a bundle connecting the Broca's area to the Supplementary Motor Area (SMA) and the pre-SMA in both hemispheres.The functional properties of this tract, and its role in degenerative dementia, such as Alzheimer's disease (AD) still need to be fully clarified. The aim of this study was to explore the microstructural integrity of the FAT in patients with AD and its potential relationship with cognitive functioning. Twenty-three patients with AD and 25 healthy subjects (HS) were enrolled. All subjects underwent cognitive and MRI examination.MRI including diffusion sequences was used for probabilistic tractography analysis. We

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Damage to the Frontal Aslant Tract Accounts for Visuo-Constructive Deficits in Alzheimer’s Disease

Serra

Gabrielli

Tuzzi

et al. 2017

JAD

View full text Add to dashboard Cite

show abstract

“…Given the areas they connect, on the one hand, and the fact that these tracts have not been observed in the non-human brain on the other, their involvement in language seems plausible. Another study that combined fiber dissection and DTI tractography [115] also discerned frontal intralobar tracts with a possible role in language. More specifically, it identi ed an association ber tract connecting [46].…”

Section: Resultsmentioning

confidence: 99%

White matter architecture of the language network

Kljajević

2014

Translational Neuroscience

View full text Add to dashboard Cite

The relevance of anatomical connectivity for understanding of the neural basis of language was recognized in the 19 th century, and yet this topic has only recently become the subject of wider research interest. In this paper, I review recent findings on white matter tracts implicated in language: the arcuate fasciculus, superior longitudinal fasciculus, extreme capsule, uncinate fasciculus, middle longitudinal fasciculus, inferior longitudinal fasciculus, and inferior fronto-occipital fasciculus. The reviewed findings on these tracts were reported in studies that used a variety of methods, from post-mortem dissection and diffusion imaging to intraoperative electrostimulation with awake surgery patients. The emerging picture suggests that there is currently no consensus with regard to the exact number and identity of the tracts supporting language, their origins, trajectories, and terminations, as well as their functional interpretation.

show abstract

“…Gross anatomical tractography (GAT) was the only method for research on the human brain about 350 years ago 1) , and currently continues to be used as a basic technique for studying the three-dimensional (3D) structure of the brain, and for providing an anatomical basis for brain surgery 2) and interpretations of tensor MRI images 3,4) . In the present study, we performed GAT on the human hippocampus.…”

Section: Introductionmentioning

confidence: 99%

Gross anatomical tractography (GAT) proposed a change from the ^|^lsquo;Two laminae concept^|^rsquo; to the ^|^lsquo;Neuronal unit concept^|^rsquo; on the structure of the human hippocampus

Yasutaka

Shinohara

Kominami

2013

Okajimas Folia Anat. Jpn.

Self Cite

View full text Add to dashboard Cite

Summary:The three dimensional structure of the human hippocampus was studied using the gross anatomical tractography (GAT) of Klingler technique. Eight hippocampi were obtained from seven donors to the Kanazawa Medical University, fixed in 5% formaldehyde, frozen and thawed twice, then dissected both by naked eye and under a dissecting microscope.The subiculum was segmented into 7-12 hillocks along the antero-posterior axis. The hillocks were organized with the white matter process and its gray matter covering. Cornu ammonis 3 (CA3) was represented by gray matter located in a longitudinal trough about 1 mm wide between the base of the fimbria and fiber bundles of the stratum lacunosum. CA3 was traversed and segmented by numerous short fiber fasciculi extending from the dentes of the margo denticulatus. The stratum radiatum, lacunosum and moleculare were differentially dissected. They not only contained systematically arranged neuronal fibers but also frameworks to allow passage of blood vessels. The polymorphic layer (PL) consisted of many italic L-shaped bars that were segmented, fused side-by-side and arrayed along the antero-posterior axis. The stratum granulosum (SG) lined the superior surface of PL as square plates and inferior surface of PL as thin folds. Thus, the SG was also segmented, although a little arbitrarily. CA4 was found not to be a neuronal plate, but instead comprised numerous neuronal rods that were segmentally arranged in accord with segmentation of CA3.On the basis of these segmentations, we conclude that, structurally, the human hippocampus is an antero-posterior succession of neuronal units, each consisting of the subicular hillock, dens, CA3, granular cell plates and folds, PL bars and CA4 rods.

show abstract

Association fibers connecting the Broca center and the lateral superior frontal gyrus: a microsurgical and tractographic anatomy

Cited by 51 publications

References 42 publications

Damage to the Frontal Aslant Tract Accounts for Visuo-Constructive Deficits in Alzheimer’s Disease

Damage to the Frontal Aslant Tract Accounts for Visuo-Constructive Deficits in Alzheimer’s Disease

White matter architecture of the language network

Gross anatomical tractography (GAT) proposed a change from the ^|^lsquo;Two laminae concept^|^rsquo; to the ^|^lsquo;Neuronal unit concept^|^rsquo; on the structure of the human hippocampus

Contact Info

Product

Resources

About