Association entre exposition professionnelle aux particules nanométriques et survenue de tumeurs du système nerveux central

Lacourt, Aude; Gramond, Céline; Audignon, Sabyne; Brochard, Patrick; Baldi, Isabelle

doi:10.1016/j.admp.2016.03.328

Cited by 1 publication

(2 citation statements)

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“…Since manufactured nanoparticles may also induce direct and indirect genotoxicity on the basis of experimental studies, epidemiological case-control studies of CNS cancers were recently reanalyzed in order to assess the relationship with incidental occupational nanoparticle exposure. In 2016, Lacourt et al (Lacourt et al, 2016) reanalyzed data from the CERENAT study (Coureau et al, 2014) including 596 cases of CNS cancer diagnosed between 2004 and 2006, and 1,192 controls. Exposure to nanoparticles was assessed via the job exposure matrix "MatPUF", linked to the individual occupational histories of study participants.…”

Section: Studies Of Occupational Combustion-resulting Nanoparticles Amentioning

confidence: 99%

“…A significant association between occupational exposure to nanoparticles and CNS tumors was seen among men, who had a 50% increased risk of CNS tumors compared to controls (OR=1.5; 95% CI: 1.1, 2.2). The increased risk was particularly pronounced at high exposure levels and for exposure durations longer than 30 years (OR=1.9; 95% CI: 1.2, 2.8), as well as after exposure to carbonaceous nanoparticles (OR=1.5; 95% CI: 1.1, 2.3) and polycyclic aromatic hydrocarbons (OR =1.6; 95% CI:1.1, 2.4) (Lacourt et al, 2016). The results of analyses by histological subtype of CNS tumor (neuroepithelial tumor/meningioma) were not statistically significant, although the risk observed for meningioma was increased twofold in the nanoparticle-exposed subgroup (OR=2.0; 95% CI: 0.8, 5.3).…”

Section: Studies Of Occupational Combustion-resulting Nanoparticles Amentioning

confidence: 99%

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Nano- and neurotoxicology: An emerging discipline

Bencsik

Lestaevel

Canu

2018

Progress in Neurobiology

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The present critical review analyzes the question of how nanoparticles from continuously growing industrial production and use of nanomaterials may impact human brain health. Available evidence suggests incomplete effectiveness of protective barriers of the brain against nanoparticles translocation to the brain. This raises concerns of potential effects of manufactured nanoparticles on brain functions, given that nanoparticle's potential to induce oxidative stress, inflammation, death by apoptosis, or changes in the level of expression of certain neurotransmitters. Most concerns have not been studied sufficiently and many questions are still open: Are the findings in animals transposable to humans? What happens when exposure is chronic or protracted? What happens to the developing brain when exposure occurs in utero? Are some nanoparticles more deleterious, given their ability to alter protein conformations and aggregation? Aside from developments in nanomedicine, the evidence already available fully justifies the need to specifically evaluate the interactions between nanoparticles and the nervous system. The available data clearly indicates the need for original dedicated experimental models and tools for neurotoxicological research on the one hand, and the need for epidemiological studies of neurodegenerative diseases in manufactured nanoparticle-exposed populations, on the other. A combination of nanotoxicology with neurology in a novel discipline, with its specific tools and methods of investigation, should enable answering still unresolved questions.

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Section: Studies Of Occupational Combustion-resulting Nanoparticles Amentioning

confidence: 99%

Section: Studies Of Occupational Combustion-resulting Nanoparticles Amentioning

confidence: 99%