Association Between ZNF804A Gene rs1344706 Polymorphism and Brain Functions in Healthy Individuals: A Systematic Review and Voxel-Based Meta-Analysis

Abstract

Objective Zinc finger protein 804A (ZNF804A) protein participates in embryonic neural repair and development. The single nucleotide polymorphism rs1344706 in ZNF804A gene is closely related to functional abnormalities of the human brain. However, these results are inconsistent. This association was verified by meta-analysis in this study. Methods Fifteen studies on functional magnetic resonance imaging involving 1710 healthy individuals were included in the systematic review and meta-analysis used by Anisotropic Effect-Size Signed Differential Mapping software. Results Functional connectivity of the right dorsolateral prefrontal cortex (rDLPFC)–left hippocampus in the rs1344706 risk allele carrier was significantly increased ( z = 2.066, p < 0.001), while those in the rDLPFC–left middle frontal gyrus ( z = −1.420, p < 0.001) and rDLPFC–right middle frontal gyrus ( z = −1.298, p < 0.001) were significantly decreased. Neural activity of the left anterior cingulate gyrus in the rs1344706 risk allele carrier was significantly decreased ( z = −2.525, p < 0.001). Sensitivity analysis was almost stable, and no publication bias was found. Conclusion The changes in brain function have a clear correlation with ZNF804A gene in healthy individuals, which indicate the contribution of genetic variants on brain dysfunction. Registration Number This meta-analysis is registered in PROSPERO (No. CRD42016051331).

Association between the rs6313 polymorphism in the 5-HTR2A gene and the efficacy of antipsychotic drugs

“…According to the method of Li et al [ 15 ], the included studies had to meet the following criteria: a) the original data were in published studies that assessed the relationship between the rs6313 polymorphism of the 5-HTR2A gene and antipsychotic drug efficacy; b) the subjects of the original study were patients with schizophrenia and other psychotic disorders or affective disorders; c) during the experiment, all subjects took antipsychotic drugs orally, and no longer received any other antipsychotic treatment; d) in the original study, drug efficacy was evaluated by the Positive and negative symptom scale (PANSS), Brief psychiatric rating scale (BPRS), Clinical global impression (CGI), Global assessment scale (GAS), Scale for the assessment of negative symptoms (SANS), and prior criteria, and the reduction rate was evaluated or patients were divided into responders and non-responders according to the reduction rate; e) the statistical methods of the original study were appropriate, and there were clear genotype or allelic frequency data. Referring to the method of Yang et al [ 16 ], a study was excluded if: a) it was a review, a conference abstract, a commentary, a news reports or other similar type of publication; b) it was a repeated publications; c) it had incomplete or insufficient data; d) it was irrelevant.…”

Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors

“…Additionally, the functional connectivity between the hippocampus and the dorsolateral prefrontal cortex is impaired (Zhang et al 2018). This gene has also been associated with dorsolateral prefrontal cortex coupling with the hippocampus and prefrontal cortex (Rasetti et al 2011;Zhao et al 2020;Yang et al 2021). Finally, a recent study has identified a genetic interaction effect between CACNA1C and ZNF804A modulating the activity ventral caudate medially and within the left hemisphere, the superior and inferior orbitofrontal gyrus, the superior temporal pole and the ventral-anterior insula during a working memory task (Guardiola-Ripoll et al 2022).…”