Association between zinc and body composition: An integrative review

Cunha, Thais Alves; Vermeulen-Serpa, Karina Marques; Grilo, Evellyn Câmara; Leite-Lais, Lúcia; Brandão-Neto, José; Vale, Sancha Helena de Lima

doi:10.1016/j.jtemb.2022.126940

Cited by 19 publications

(3 citation statements)

References 53 publications

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“…The Ca, Mg, and Zn minerals showed a positive correlation here and were associated with human muscle mass [ 41 ]. Zinc is an essential mineral for lean body mass synthesis, but relatively large amounts of Zn are needed for new tissue synthesis [ 42 ]. Moreover, we found positive correlations between unsaturated fatty acids and Cu and Cr.…”

Section: Discussionmentioning

confidence: 99%

Differential Allele-Specific Expression Revealed Functional Variants and Candidate Genes Related to Meat Quality Traits in B. indicus Muscle

Bruscadin

Cardoso

Diniz

et al. 2022

Genes

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Traditional transcriptomics approaches have been used to identify candidate genes affecting economically important livestock traits. Regulatory variants affecting these traits, however, remain under covered. Genomic regions showing allele-specific expression (ASE) are under the effect of cis-regulatory variants, being useful for improving the accuracy of genomic selection models. Taking advantage of the better of these two methods, we investigated single nucleotide polymorphisms (SNPs) in regions showing differential ASE (DASE SNPs) between contrasting groups for beef quality traits. For these analyses, we used RNA sequencing data, imputed genotypes and genomic estimated breeding values of muscle-related traits from 190 Nelore (Bos indicus) steers. We selected 40 contrasting unrelated samples for the analysis (N = 20 animals per contrasting group) and used a beta-binomial model to identify ASE SNPs in only one group (i.e., DASE SNPs). We found 1479 DASE SNPs (FDR ≤ 0.05) associated with 55 beef-quality traits. Most DASE genes were involved with tenderness and muscle homeostasis, presenting a co-expression module enriched for the protein ubiquitination process. The results overlapped with epigenetics and phenotype-associated data, suggesting that DASE SNPs are potentially linked to cis-regulatory variants affecting simultaneously the transcription and phenotype through chromatin state modulation.

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Section: Discussionmentioning

confidence: 99%

Differential Allele-Specific Expression Revealed Functional Variants and Candidate Genes Related to Meat Quality Traits in B. indicus Muscle

Bruscadin

Cardoso

Diniz

et al. 2022

Genes

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“…The relationship between the decrease in SZn with OW/OB has been evaluated through oxidative stress at the level of adipose tissue [ 97 , 101 , 102 ]. To date, the molecular mechanisms are not clear, but it has been shown that under these conditions of OW/OB, the increase in visceral fat due to OW and OB contributes to the secretion of cytokines such as IL-6, IL-8, and TNF-α, as well as an increase in the cortisol synthesis.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City

Martínez-Navarro

Vilchis-Gil

Cossío-Torres

et al. 2022

Biol Trace Elem Res

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Zinc (Zn) participates as a cofactor for many enzymes in the cellular metabolism, and its serum levels have been associated with different metabolic diseases, especially obesity (OB). Nevertheless, its associations are not clear in the children population. The objective of this study is to evaluate the association between serum Zn levels (SZn) with overweight/obesity status (OW/OB), as well as its cardiometabolic traits in a population of children in Mexico City. Anthropometrical data (body mass index z score (BMIz)), demographic variables (age and sex), and cardiometabolic traits (total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), triglycerides (TG), fasting plasma glucose (FPG), and insulin) were analyzed in this cross-sectional study. SZn were measured by inductively coupled plasma mass spectrometry (ICP–MS). The population included 210 children from Mexico City (girls ( n = 105) and boys ( n = 105)) between ages 6 and 10 years. Normal-weight (NW) schoolchildren had higher SZn concentrations (66 µg/dL; IQR: 48 to 91) compared to OW or OB schoolchildren (61 µg/dL; IQR: 45 to 76). The data showed a significant negative association between SZn and BMIz without sex exclusion ( r = − 0.181 and p = 0.009). The boy’s population did not show an association between the SZn and BMIz compared to the girl’s population which showed a significant negative association ( r = − 0.277 and p = 0.004). In addition, other associations were found between SZn and TC (boys ( r = 0.214 and p = 0.025), LDLc (boys ( r = 0.213 and p = 0.029), and TG (girls ( r = − 0.260 and p = 0.007)). Moreover, 38.6% of the total children in our population study had Zn deficiency (ZnD). NW schoolchildren had higher SZn concentrations compared to OW or OB schoolchildren. A diet low in Zn can be a factor to evaluate in the development of childhood OB in Mexico. However, further studies need to be performed on the children Mexican population to replicate and confirm our findings.

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“…Studies have shown that the levels of serum zinc (Zn) are often lowered in patients who have chronic liver diseases [70]. Other studies have shown that zinc (Zn) deficiency altered the functions of hepatocytes as well as the immune responses in some inflammatory liver diseases [71], which as a consequence, initiated some metabolic abnormalities that include insulin resistance [72], iron (Fe) overload [11], hepatic steatosis [73], and hepatic encephalopathy in patients suffering from a chronic liver disease [74].…”

Section: Zinc (Zn)mentioning

confidence: 99%

The Roles and Pathogenesis Mechanisms of a Number of Micronutrients in the Prevention and/or Treatment of Chronic Hepatitis, COVID-19 and Type-2 Diabetes Mellitus

Sumaily

2022

Nutrients

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A trace element is a chemical element with a concentration (or other measures of an amount) that is very low. The essential TEs, such as copper (Cu), selenium (Se), zinc (Zn), iron (Fe) and the electrolyte magnesium (Mg) are among the most commonly studied micronutrients. Each element has been shown to play a distinctive role in human health, and TEs, such as iron (Fe), zinc (Zn) and copper (Cu), are among the essential elements required for the organisms’ well-being as they play crucial roles in several metabolic pathways where they act as enzyme co-factors, anti-inflammatory and antioxidant agents. Epidemics of infectious diseases are becoming more frequent and spread at a faster pace around the world, which has resulted in major impacts on the economy and health systems. Different trace elements have been reported to have substantial roles in the pathogenesis of viral infections. Micronutrients have been proposed in various studies as determinants of liver disorders, COVID-19 and T2DM risks. This review article sheds light on the roles and mechanisms of micronutrients in the pathogenesis and prevention of chronic hepatitis B, C and E, as well as Coronavirus-19 infection and type-2 diabetes mellitus. An update on the status of the aforementioned micronutrients in pre-clinical and clinical settings is also briefly summarized.

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Association between zinc and body composition: An integrative review

Cited by 19 publications

References 53 publications

Differential Allele-Specific Expression Revealed Functional Variants and Candidate Genes Related to Meat Quality Traits in B. indicus Muscle

Differential Allele-Specific Expression Revealed Functional Variants and Candidate Genes Related to Meat Quality Traits in B. indicus Muscle

Relationship of Serum Zinc Levels with Cardiometabolic Traits in Overweight and Obese Schoolchildren from Mexico City

The Roles and Pathogenesis Mechanisms of a Number of Micronutrients in the Prevention and/or Treatment of Chronic Hepatitis, COVID-19 and Type-2 Diabetes Mellitus

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