Association between winter cold spells and acute myocardial infarction in Lithuania 2000–2015

Vaičiulis, Vidmantas; Jaakkola, Jouni J. K.; Radišauskas, Ričardas; Tamošiūnas, Abdonas; Lukšienė, Dalia; Ryti, Niilo

doi:10.1038/s41598-021-96366-9

Cited by 13 publications

(15 citation statements)

References 39 publications

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“…This meta-analysis revealed that MI was more likely to occur during colder seasons than in warmer seasons, and the highest MI incidence was observed in winter. The results of our meta-analysis are consistent with the results of clinical studies in which an association of an increase in MI risk with a decrease in air temperature was observed in various climatic zones [7,[40][41][42][43][44]. However, seasonal MI risk was increased in regions with small differences between winter and summer temperatures.…”

Section: Discussionsupporting

confidence: 90%

“…It is generally believed that low MI risk in women is due to the protective effects of female sex hormones, but differences in lifestyle (diet, smoking, alcohol) may also be important [15]. Other authors also reported that male gender and old age increased MI risk in cold weather [10,11,41,42,44,49]. Moreover, Hong et al and Park et al [24,35] observed that male gender increases MI risk in the heat.…”

Section: Discussionmentioning

confidence: 99%

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Seasonal dynamics of myocardial infarctions in regions with different types of a climate: a meta-analysis

et al. 2022

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Background It is known that cardiovascular events (CVE) occur more often in winter than in summer. However, dependence of myocardial infarction (MI) risk of on various meteorological factors is still not fully understood. Also, the dependence of the seasonal dynamics of MI on gender and age has not yet been studied. The purpose of our meta-analysis is to reveal dependence of the circannual dynamics of MI hospitalizations on gender, age, and characteristics of a region’s climate. Main body Using Review Manager 5.3, we performed a meta-analysis of 26 publications on the seasonal dynamics of MI. In our meta-analysis, the relative MI risk was higher in colder compared to warmer seasons. Old age insignificantly increased the seasonal MI risk; gender did not affect the seasonal dynamics of MI, but MI was more common in men than in women. The severity of the seasonal dynamics of MI risk depended on the climate of the region. In a climate with a small amplitude of circannual fluctuations in air temperature, atmospheric pressure, and partial oxygen density in the air, as well as in regions where air humidity is higher in winter than in summer, an increase in MI risk in winter compared to summer was significant. It was not significant in regions with opposite climatic tendencies. Conclusions Based on the results of our studies, it can be concluded that a decrease in air temperature increases in MI risk; in addition, hypoxia in the hot season can provoke CVE associated with ischemia.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Seasonal dynamics of myocardial infarctions in regions with different types of a climate: a meta-analysis

et al. 2022

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“…linked to a higher risk of MI emergency department visits and hospitalizations. [5][6][7][8] Although some previous evidence indicates that exposure to nonoptimum temperatures is significantly associated with an increased risk of MI mortality, [9][10][11] the association between ETEs and MI mortality remains poorly understood.…”

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confidence: 99%

Extreme Temperature Events, Fine Particulate Matter, and Myocardial Infarction Mortality

Huang

Shi³

et al. 2023

Circulation

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BACKGROUND: Extreme temperature events (ETEs), including heat wave and cold spell, have been linked to myocardial infarction (MI) morbidity; however, their effects on MI mortality are less clear. Although ambient fine particulate matter (PM 2.5 ) is suggested to act synergistically with extreme temperatures on cardiovascular mortality, it remains unknown if and how ETEs and PM 2.5 interact to trigger MI deaths. METHODS: A time-stratified case-crossover study of 202 678 MI deaths in Jiangsu province, China, from 2015 to 2020, was conducted to investigate the association of exposure to ETEs and PM 2.5 with MI mortality and evaluate their interactive effects. On the basis of ambient apparent temperature, multiple temperature thresholds and durations were used to build 12 ETE definitions. Daily ETEs and PM 2.5 exposures were assessed by extracting values from validated grid datasets at each subject’s geocoded residential address. Conditional logistic regression models were applied to perform exposure-response analyses and estimate relative excess odds due to interaction, proportion attributable to interaction, and synergy index. RESULTS: Under different ETE definitions, the odds ratio of MI mortality associated with heat wave and cold spell ranged from 1.18 (95% CI, 1.14–1.21) to 1.74 (1.66–1.83), and 1.04 (1.02–1.06) to 1.12 (1.07–1.18), respectively. Lag 01-day exposure to PM 2.5 was significantly associated with an increased odds of MI mortality, which attenuated at higher exposures. We observed a significant synergistic interaction of heat wave and PM 2.5 on MI mortality (relative excess odds due to interaction >0, proportion attributable to interaction >0, and synergy index >1), which was higher, in general, for heat wave with greater intensities and longer durations. We estimated that up to 2.8% of the MI deaths were attributable to exposure to ETEs and PM 2.5 at levels exceeding the interim target 3 value (37.5 μg/m 3 ) of World Health Organization air quality guidelines. Women and older adults were more vulnerable to ETEs and PM 2.5 . The interactive effects of ETEs or PM 2.5 on MI mortality did not vary across sex, age, or socioeconomic status. CONCLUSIONS: This study provides consistent evidence that exposure to both ETEs and PM 2.5 is significantly associated with an increased odds of MI mortality, especially for women and older adults, and that heat wave interacts synergistically with PM 2.5 to trigger MI deaths but cold spell does not. Our findings suggest that mitigating both ETE and PM 2.5 exposures may bring health cobenefits in preventing premature deaths from MI.

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“…The irrefutable association between low temperatures and increased prevalence of myocardial infarction events [8][9] is common to both in Northern and Southern hemispheres [10] , as well as to countries at various stages of economic development [11] . Hence, the investigation on the mechanisms underlying cold-exacerbated CVD mortalities is highly significant, as seasonal changes in temperature and the natural environment impact global public health.…”

Section: Cardiovascular Disease and Temperaturementioning

confidence: 99%

Increased risk of cardiovascular disease in cold temperatures

Jin

2022

Frigid Zone Medicine

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Association between winter cold spells and acute myocardial infarction in Lithuania 2000–2015

Cited by 13 publications

References 39 publications

Seasonal dynamics of myocardial infarctions in regions with different types of a climate: a meta-analysis

Seasonal dynamics of myocardial infarctions in regions with different types of a climate: a meta-analysis

Extreme Temperature Events, Fine Particulate Matter, and Myocardial Infarction Mortality

Increased risk of cardiovascular disease in cold temperatures

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