Association between well-characterized lung cancer lncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer

Gong, Wei; Peng, Jing; Yin, Ji‐Ye; Li, Xiang Ping; Zheng, Wei; Xiao, Ling; Tan, Li; Xiao, Di; Chen, Yi Xin; Li, Xi; Zhou, Hong; Liu, Zhao‐Qian

doi:10.1038/aps.2016.164

Cited by 60 publications

(56 citation statements)

References 35 publications

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“…Another layer of interaction between these lncRNAs and miRNAs includes their regulatory role on the biogenesis of miRNAs. Taken together, a comprehensive approach is needed to assess contribution of these lncRNAs in the tumorigenesis Gong et al (2016) NSCLC 467 lung cancer patients rs6983267: reduced incidence of severe hematologic toxicity Gong et al (2017) Note. BM: bone marrow; PB: peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

Colon Cancer‐Associated Transcripts 1 and 2: Roles and functions in human cancers

Ghafouri‐Fard

Taheri

2019

Journal Cellular Physiology

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The long noncoding RNAs (lncRNAs) Colon Cancer‐Associated Transcripts 1 and 2 (CCAT1 and CCAT2) are located in a recurrently amplified region in cancers. Their proximity with the Myc oncogene and their interactions with its promoter provided further evidence for their contribution in the tumorigenesis processes. Several cell line and clinical studies have shown upregulation of these lncRNAs in diverse malignancies. Moreover, some single nucleotide variants within these genes have been associated with cancer risk or therapeutic response in different populations. Besides, these two lncRNAs act as sponges for some tumor suppressor microRNAs (miRNAs), thus promoting cancer evolution. In the current study, we review recent literature about their expression level, interaction with cancer‐related pathways, their role in determination of cell fate and their contribution in malignant phenotype characteristics. Taken together, the current literature shows that these lncRNAs are putative targets for design of novel treatment strategies. Moreover, their expression levels in biopsied samples, exosomes, and sera of patients might be applied as diagnostic biomarkers or markers for patient follow‐up.

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Section: Discussionmentioning

confidence: 99%

Colon Cancer‐Associated Transcripts 1 and 2: Roles and functions in human cancers

Ghafouri‐Fard

Taheri

2019

Journal Cellular Physiology

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“…The only difference between lncRNAs and messenger RNAs is that lncRNAs lack protein coding potential . More than 40 lncRNAs have been reported to be associated with the initiation, progression, and drug resistance of LC . KCNQ1OT1, an lncRNA responsible for suppressing a cluster of genes in cis, has been shown to be involved in multiple cancers .…”

Section: Introductionmentioning

confidence: 99%

Overexpression of long non‐coding RNA KCNQ1OT1 is related to good prognosis via inhibiting cell proliferation in non‐small cell lung cancer

et al. 2018

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BackgroundLung cancer (LC) is the most common malignancy in the world. Many long non‐coding RNAs (lncRNAs) have been reported to be associated with LC; however, the function of KCNQ1OT1 in LC requires exploration.MethodsWe conducted in silico analysis with data from The Cancer Genome Atlas to investigate the association between KCNQ1OT1 and LC. A Kaplan–Meier plotter was used to analyze the function of KCNQ1OT1 on LC patient prognosis. Quantitative reverse transcription‐PCR (qRT‐PCR) was performed to confirm previous results. An A549 lung cancer cell was transfected with pcDNA‐KCNQ1OT1, and methyl thiazolyl tetrazolium assay was performed to investigate the function of KCNQ1OT1 on cell proliferation. in vivo assay was performed with nude mice.ResultsBioinformatics analysis and qRT‐PCR indicated that KCNQ1OT1 expression was higher in stage I LC patients (P < 0.01), and survival analysis showed that high expression of KCNQ1OT1 in LC patients was associated with better prognosis (P < 0.05). qRT‐PCR showed a negative correlation between KCNQ1OT1 and Ki67 expression and tumor size (P < 0.01), which indicated that KCNQ1OT1 is associated with tumor growth in LC. There was no significant correlation between KCNQ1OT1 level and lymph node metastasis (P > 0.05). KCNQ1OT1 overexpression significantly inhibited cell proliferation and tumor growth in vitro and in vivo (P < 0.05).ConclusionOur preliminary data showed that KCNQ1OT1 is overexpressed in early stage LC and is correlated with better prognosis in LC patients, possibly by suppressing cell proliferation.

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“…Previously, several meta-analysis on aberration of H19 have been conducted thanks to the identi cation of numerous lncRNAs [23][24]. Though the results were contrary to many studies, a meta-analysis conducted by Lv et al revealed that rs217727 were uncorrelated to overall cancer risk [20].…”

Section: Discussionmentioning

confidence: 97%

Meta-analysis and trial sequential analysis of LncRNA H19 polymorphic variants on susceptibility to cancer

Wang

Zhu

Wang

et al. 2020

Preprint

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Background: Although myriad researches upon the associations between LncRNA H19 polymorphic variants (rs2839698 G A, rs3024270 C G, rs2107425 C T, rs2735971 A G and rs217727 G A) and the susceptibility to cancer have been conducted, these results remained contradictory and perplexing. Basing on that, a systematic review and updated meta-analysis was conducted to anticipate a fairly precise assessment about these associations. Methods: We retrieved the electronic databases EMBASE, PubMed and Web of Science for valuable academic studies before October 1st, 2019. Ultimately, 24 of which were encompassed after screening, and the available data was extracted and integrated. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) was adopted to evaluate the strength of these associations. For multi-level investigation, subgroup analysis derived from source of controls together with genotypic method was preformed. Eventually, 24 articles altogether embodying 52 studies were included. Results: The results illuminated that LncRNA H19 SNPs mentioned above were all irrelevant to cancer susceptibility. Nevertheless, crucial results were found concentrated in population-based control group when subgroup analysis by source of controls were performed in H19 mutation rs2839698 and rs2735971. Meanwhile, in the stratification analysis by genotypic method, apparent cancer risks were discovered by TaqMan method in H19 mutation rs2107425 and rs3024270. Then, trial sequential analysis (TSA) demonstrated that the results about such associations were firm evidence of effect, except rs2735971 polymorphism. Conclusion: Therefore, this meta-analysis indicated that LncRNA H19 SNPs were not associated with the susceptibility to human cancer. However, after the stratification analysis, inconsistent results still existed in different genotypic method and source of control. Thus, more highquality studies on cancer patients of different factors were needed to confirm these findings.

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Association between well-characterized lung cancer lncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer

Cited by 60 publications

References 35 publications

Colon Cancer‐Associated Transcripts 1 and 2: Roles and functions in human cancers

Colon Cancer‐Associated Transcripts 1 and 2: Roles and functions in human cancers

Overexpression of long non‐coding RNA KCNQ1OT1 is related to good prognosis via inhibiting cell proliferation in non‐small cell lung cancer

Meta-analysis and trial sequential analysis of LncRNA H19 polymorphic variants on susceptibility to cancer

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