Association between Weight Gain and Symptoms of Gastroesophageal Reflux in the General Population

Rey, Enrique; Moreno-Elola-Olaso, Cristina; Artalejo, Fernando Rodrı́guez; Locke, G. Richard; Dı́az-Rubio, Manuel

doi:10.1111/j.1572-0241.2006.00412.x

Cited by 60 publications

(42 citation statements)

References 23 publications

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“…However, some gender differences were noted-a weight loss of 5-10% led to a significant reduction in overall GERD scores (P < 0.05) in women; whereas among men, a significant improvement in GERD symptom scores (P < 0.01) was observed after a weight loss of ≥10% of baseline body weight. Similar to this concept, new onset or worsening of pre-existing GERD may occur only after certain threshold weight change as was reported in previous study by Rey et al (39) In that study subjects who gained >5 kg showed three times significantly higher frequency of new onset GERD (39). Although a positive and significant correlation between weight loss and GERD scores was noted, it appears that the correlation is not linear and more complex.…”

Section: Discussionsupporting

confidence: 74%

Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: A Prospective Intervention Trial

Singh¹,

Lee²,

Gupta³

et al. 2012

Obesity

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Objective-Weight gain is an important risk factor for gastroesophageal reflux disease (GERD); however, whether weight loss can lead to resolution of GERD symptoms is not clear. Our aim was to measure the impact of weight loss on GERD symptoms.Design and Methods-In a prospective cohort study at a tertiary referral center, overweight/ obese subjects (BMI 25-39.9 kg/m2) were enrolled in a structured weight loss program. Weight loss strategies included dietary modifications, increased physical activity and behavioral changes. At baseline and at 6 months, BMI and waist circumference were measured and all participants completed a validated reflux disease questionnaire.Results-A total of 332 adult subjects, mean age 46 years and 66% women were prospectively enrolled. At baseline, the mean body weight, BMI, and waist circumference were 101 (±18) kg, 35 (±5) kg/m2 and 103 (±13) cm. At 6 months, majority of the subjects (97%) lost weight (average weight loss: 13 ± 7.7 kg) and as compared with baseline, there was a significant decrease in the overall prevalence of GERD (15 vs. 37%; P < 0.01) and the mean GERD symptom score (1.8 vs. 5.5; P < 0.01). Overall, 81% of the subjects had reduction in GERD symptom scores; 65% had complete resolution and 15% had partial resolution of reflux symptoms. There was a significant correlation between % body weight loss and reduction in GERD symptom scores (r = 0.17, P < 0.05).Conclusions-In conclusion, the overall prevalence of GERD symptoms is high (37%) in overweight and obese subjects. A structured weight loss program can lead to complete resolution of GERD symptoms in the majority of these subjects.

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Section: Discussionsupporting

confidence: 74%

Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: A Prospective Intervention Trial

Singh¹,

Lee²,

Gupta³

et al. 2012

Obesity

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“…Weight gain of at least 5 kg, independent of BMI, has been shown to be associated with new or exacerbation of already existing GERD symptoms [12]. In contrast, weight loss has been shown to result in symptom improvement in GERD patients [13,14].…”

Section: Introductionmentioning

confidence: 98%

The Pathophysiological Mechanisms of GERD in the Obese Patient

Fass

2008

Dig Dis Sci

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Obesity has increased dramatically in the last 30 years, affecting 33% of the adult population in the United States. Increase in body mass index has been shown to be associated with the increase in the prevalence of gastroesophageal reflux disease (GERD) symptoms, esophageal mucosal injury, and GERD complications. The putative mechanisms responsible for the close relationship between GERD and increased body mass index include increased intragastric pressure, increased gastroesophageal pressure gradient, esophageal motor and sensory abnormalities, increase in prevalence of hiatal hernia, increase in serum female hormonal levels, diet, and increase in comorbidities. Whilst the current efforts are to focus on one major underlying mechanism, it is highly likely that multiple factors contribute to the increased prevalence of GERD in the obese patient.

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“…On the contrary, a weight loss amounting to a decrease of BMI of 3.5 kg/m 2 over a period of 14 years decreased the risk of frequent GERD symptoms by nearly 40% (odds ratio, 0.64; 95% confidence interval, 0.42 -0.97) as compared to women without weight loss [4]. In another population-based study in Spain, the subjects with a weight gain over 5 kg coexists with an increased new GERD symptoms (odds ratio, 3.0; 95% confidence interval, 1.6 -6.0) [9]. A hospital-based study found a weight loss of 5-10% in women and > 10% in men, led to a significant reduction in overall GERD symptoms scores [10].…”

Section: Discussionmentioning

confidence: 94%

Body Weight Reduction Improves Both Reflux Symptoms and Esophageal Physiologic Examination

et al. 2015

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Association between Weight Gain and Symptoms of Gastroesophageal Reflux in the General Population

Abstract: Weight gain is associated with GERS, independently of BMI.

Cited by 60 publications

References 23 publications

Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: A Prospective Intervention Trial

Weight Loss Can Lead to Resolution of Gastroesophageal Reflux Disease Symptoms: A Prospective Intervention Trial

The Pathophysiological Mechanisms of GERD in the Obese Patient

Body Weight Reduction Improves Both Reflux Symptoms and Esophageal Physiologic Examination

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