Association between weight fluctuation and fasting insulin concentration in Japanese men

Yatsuya, Hiroshi; Koji, Takehiko; Yoshida, Tomohide; Hori, Yoko; Zhang, H.; Ishikawa, Miyuki; Zhu, Sijin; Kondo, Takaaki; Toyoshima, Hideaki

doi:10.1038/sj.ijo.0802221

Cited by 50 publications

(38 citation statements)

References 23 publications

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“…An interesting observation from the studies analyzed above is that the negative health consequences of weight cycling are readily seen in people of normal weight. 39,66,69 As the onset of a pattern of weight cycling is shifting towards younger ages and, as cardiovascular risk factors, even when only moderately present, act together in multiplicative way to lead slowly over many years to cardiovascular events, an increase in the prevalence of cardiovascular diseases associated with weight cycling is expected in the next few decades.…”

Section: Dyslipidemiamentioning

confidence: 99%

“…In another study of a second group of 664 middle-aged Japanese men investigating the relationship between weight cycling and the metabolic syndrome, a positive correlation was found between high fasting glucose and a history of weight cycling, and similarly the significance was only seen in the group of men with a BMI o25 kg/m 2 . 39 Altogether, these observations suggest that weight cycling may promote insulin resistance in normal weight subjects and may be deleterious to health by promoting diabetes, either per se 39,66 or by favoring weight gain. 65 …”

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confidence: 99%

“…65 However, a direct association between weight cycling and fasting hyperinsulinemia has been demonstrated in lean and mildly overweight Japanese subjects. 66 In a cross-sectional analysis of 1932 middle-aged Japanese men with an average BMI of 22.7 kg/m 2 , a positive association was found between fasting insulin concentration and a history of weight fluctuations (over the last B30 years). Individuals with larger weight fluctuations had higher fasting insulin, independently of BMI and other confounding factors (P-value for trend o0.001).…”

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confidence: 99%

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Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the ‘repeated overshoot’ theory

et al. 2006

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In people trying to lose weight, there are often repeated cycles of weight loss and regain. Weight cycling is, however, not limited to obese adults but affects people of normal weight, particularly young women, who are unhappy with their appearance. Furthermore, the onset of a pattern of weight cycling is shifting towards younger ages, owing to the increasing prevalence of overweight and obesity in children and adolescents, and the pressure from the media and society for a slim image even for normal weight children. Although there is still controversy whether weight cycling promotes body fat accumulation and obesity, there is mounting evidence from large population studies for increased cardiovascular risks in response to a behavior of weight cycling. Potential mechanisms by which weight cycling contributes to cardiovascular morbidity include hypertension, visceral fat accumulation, changes in adipose tissue fatty acid composition, insulin resistance and dyslipidemia. Moreover, fluctuations in blood pressure, heart rate, sympathetic activity, glomerular filtration rate, blood glucose and lipids that may occur during weight cycling -with overshoots above normal values during weight regain periods -put an additional load on the cardiovascular system, and may be easily overlooked if humans or animals are studied during a state of relatively stable weight. Overshoot of those risks factors, when repeated over time, will stress the cardiovascular system and probably contribute to the overall cardiovascular morbidity of weight cycling.

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Section: Dyslipidemiamentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the ‘repeated overshoot’ theory

et al. 2006

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“…Assuming height doesn't vary, the value for body weight will be the same. Yatsuya et al (2003) estimate fluctuations in the same way, and report a mean of 1.22kg (mean subject weight not reported). These estimates are encouragingly similar in magnitude to those obtained from our modelling.…”

Section: Discussionmentioning

confidence: 99%

The behaviour of a neutral model of weight regulated only by body mass

Horgan

2011

Journal of Theoretical Biology

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While there are many mechanisms that may be involved in the regulation of body mass in humans and other animals, it is not so clear how much regulation is needed beyond the negative feedback effect of body mass itself. Here we model weight changes as a stochastic process, and show that it behaves approximately as an autoregressive process. Using published estimates of the energy cost of weight gain, the effect of weight on resting metabolic rate and the daily variation in intake and activity, we show that fluctuations in weight will be small. The effect of excess intake is also examined, and the assumptions and limitations of the model are discussed.2

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“…18,19 Its aim was to determine factors associated with the development of cardiovascular diseases. The study began in 1997, when 2,896 male employees of a manufacturing company, aged 34-59 years, were recruited as potential participants.baseline characteristics of the participants.…”

Section: Subjectsmentioning

confidence: 99%

Serum Phospholipid Transfer Protein Mass as a Possible Protective Factor for Coronary Heart Diseases

Yatsuya

Koji

Hashimoto

et al. 2004

Circ J

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n inverse relationship between high-density lipoprotein (HDL) cholesterol and cardiovascular diseases has been demonstrated in epidemiologic studies, 1,2 and is often explained by the capacity of HDL to transport cholesterol from peripheral tissues to the liver, known as reverse cholesterol transport. 3 In this process, pre--HDL, a quantitatively minor subfraction of HDL, is thought to play a critical role because it acts as an efficient acceptor in the cholesterol efflux process from the plasma membrane of peripheral cells. 3,4 Phospholipid transfer protein (PLTP) is capable of generating pre--HDL by inducing HDL conversion, a process that remodels a homogeneous HDL fraction into populations of large and small HDL particles. [5][6][7][8] The transfer of phospholipids to immature HDL in the process of HDL maturation is also essential in maintaining reverse cholesterol transport. 5,9,10 In addition, PLTP has other roles, such as the transfer oftocopherol to cell membrane for the maintenance of endothelial function, or the transfer of lipopolysaccharide to Circulation Journal Vol.68, January 2004 lipoproteins, which leads to neutralization of its potent inflammatory function. 5 Altogether, PLTP can be considered to play an important role in the prevention of atherosclerosis, and thus it has recently attracted much attention.Previous studies regarding PLTP examined its phospholipid transfer activity in patho-physiologic states in human or experimental models. 11-14 Sandwich enzyme-linked immunosorbent assay with 2 monoclonal antibodies to human PLTP has been recently introduced to assay PLTP concentration, 15,16 but the significance of the PLTP concentration in human diseases is incompletely understood. 5,17 It is, therefore, important to evaluate whether an elevated concentration of serum PLTP is associated with an increased or decreased risk of cardiovascular diseases. We examined serum PLTP in relation to newly diagnosed cardiovascular diseases in a middle-aged worksite-based cohort of men in Japan. We also examined the association of serum PLTP concentration with other cardiovascular risk factors. Methods SubjectsThe present analysis is based on a cohort of male workers in a worksite in Aichi prefecture, central Japan. 18,19 Its aim was to determine factors associated with the development of cardiovascular diseases. The study began in 1997, when 2,896 male employees of a manufacturing company, aged 34-59 years, were recruited as potential participants. A self-administered questionnaire was used to assess the

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Association between weight fluctuation and fasting insulin concentration in Japanese men

Cited by 50 publications

References 23 publications

Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the ‘repeated overshoot’ theory

Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the ‘repeated overshoot’ theory

The behaviour of a neutral model of weight regulated only by body mass

Serum Phospholipid Transfer Protein Mass as a Possible Protective Factor for Coronary Heart Diseases

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