Association between weight-adjusted waist index and arterial stiffness in hypertensive patients: The China H-type hypertension registry study

Abstract

ObjectiveExploring the relationship between (weight-adjusted waist index) WWI and arterial stiffness (AS) in the total and different BMI populations among patients with hypertension.MethodsThis study enrolled 5232 hypertensive subjects, a subset of the China H-type Hypertension Registry Study. WWI was calculated as WC (cm) divided by the square root of weight (kg). Brachial-ankle pulse wave velocity (baPWV) was measured to determine AS.ResultsThe mean WWI was 10.97 (0.78)cm/√kg. In multiple logistic analyses showed that there were significant dose-dependent association between WWI with baPWV in a dose-dependent manner in total population (β 57.98, 95% CI 44.06-71.90), and in different BMI group: group 1 (BMI<18.5kg/m2) (β 94.30, 95% CI 39.36-149.23), group 2 (18.5-23.9kg/m2) (β 74.21, 95% CI 54.57-93.85), group 3 (≥24kg/m2) (β 26.11, 95% CI 5.22-47.01). In stratified analysis, stronger associations between WWI and baPWV were observed in patients with higher BP or lower BMI. Sensitivity analysis by excluding patients treated with lipid-lowering agents did not change the association between WWI and baPWV.ConclusionFor hypertensive patients, we found that WWI was positively associated with baPWV in different BMI groups. WWI might be considered as an intervening factor in preventing and treatment of AS, besides BP management.

The relationship between obesity associated weight-adjusted waist index and the prevalence of hypertension in US adults aged ≥60 years: a brief report

“…Due to ethnicities, cultural differences, diet habits, genetic variances, and lifestyle factors between Chinese and American older adults populations, we found that WWI among older adults hypertensive patients in the United States was notably greater than Showcases the results of a subgroup analysis that focuses on the correlation between the prevalence of hypertension in older adults individuals and WWI. (34). Thus, these differences may explain the discrepancy in findings between our study and the Rural Chinese Cohort Study.…”

J-Shaped Relationship Between Weight-Adjusted-Waist Index and Cardiovascular Disease Risk in Hypertensive Patients with Obstructive Sleep Apnea: A Cohort Study

“…This suggests that WWI could be a valuable factor in managing arterial stiffness, alongside blood pressure control, to mitigate the risk of future CVD events. 22 Additionally, WWI’s reliability extends to predicting stroke subtypes of CVD, where a significant relationship between higher WWI levels and increased stroke incidence was observed. 19 The unique focus of our study was on evaluating the impact of the WWI on CVD risk in patients with hypertension and OSA.…”

“…Our study is basically consistent with previous studies, indicating a significant positive correlation between central visceral obesity, as measured by the WWI, and CVD along with its subtypes. 18 , 19 , 22 , 25 Specifically, a national cohort study in South Korea demonstrated that WWI is a superior predictor of CVD mortality compared to BMI, WC, and WHtR, highlighting its predictive power. 18 Furthermore, WWI is strongly associated with arterial stiffness, a known risk factor for CVD.…”