Abstract:Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for whom voriconazole demonstrated a large variability. The study aimed at describing factors associated with trough voriconazole concentrations in critically ill patients and evaluating the impact of voriconazole concentrations on adverse effects. A 2-year retrospective multicenter cohort study (NCT04502771) was conducted in six intensive care units. Adult patients who had at leas… Show more
“…For example, only 67% of patients receiving fluconazole had a therapeutic drug exposure. 7 Thus, the DALI study, like other recent antifungal PK studies, [8] , [9] , [10] supports a larger-scale investigation of the extent of suboptimal antifungal exposures and therefore inappropriate antifungal dosing in critically ill patients.…”
“…For example, only 67% of patients receiving fluconazole had a therapeutic drug exposure. 7 Thus, the DALI study, like other recent antifungal PK studies, [8] , [9] , [10] supports a larger-scale investigation of the extent of suboptimal antifungal exposures and therefore inappropriate antifungal dosing in critically ill patients.…”
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