Association Between Vitamin D Receptor Gene Polymorphisms and Severe Chronic Periodontitis in a Chinese Population

Chun-xian, Wang; Zhao, Hongyu; Xiao, Limin; Xie, Chun; Wu, Fan; Sun, Shaoli; Xie, Baoyi; Zhang, Jincai

doi:10.1902/jop.2009.080465

Cited by 46 publications

(45 citation statements)

References 36 publications

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“…In particular, the TT genotype and the presence of T allele are associated with chronic periodontal disease in Japanese, Chinese and Caucasian subjects (23)(24)(25)(26)(27). This data is also in accordance with our previous study which showed a strong correlation between TT genotype of Italian subjects and chronic periodontitis (OR 3.59) but also with aggressive periodontal disease (28).…”

Section: Taqisupporting

confidence: 92%

Vitamin D: relevance in dental practice

Martelli¹

2014

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SummaryObjective. The potential role of VDR gene variations in modulating periodontal susceptibility have been a subject of scientific investigations. The aim of this paper is to perform a literature review of the potential correlation between Vitamin D Receptor (VDR) gene polymorphisms and periodontal disease. Materials and methods. A PubMed literature search was made using "vitamin d receptor polymorphisms periodontal disease" as keys words. Only clinical studies in "Humans" as species and "English" as language were considered. Titles and abstracts of all identified records were examined to determine if the candidate articles contained sufficient information on the association of the VDR polymorphisms and the risk of development periodontal disease. Conclusions. Vitamin D may affect the risk of developing periodontal disease via an effect on bone mineral density or via immunomodulatory effects. There are scientific evidences about the correlation between some VDR polymorphisms, periodontitis and bone metabolism. The use of new simple and economics diagnostic techniques of genetic screening, allows to the dental specialists to identify periodontal patients with possible decreased bone mineral density. The complete acquisition of awareness by dentists of the strong relationship between skeletal bone density with periodontal health and osteointegrated implant success, could open a new therapeutic approach for periodontists with an important role in the early detection of osteoporosis and a better patient compliance of the periodontal therapy.

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Section: Taqisupporting

confidence: 92%

Vitamin D: relevance in dental practice

Martelli¹

2014

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“…Hennig et al (1999) concluded that carriage of the less frequent t allele in VDR was associated with an increased risk for localized, but not generalized, disease. Sun et al (2002) and Tachi et al (2001) found that the VDR TaqI Tt genotype and the t allele may be a risk factor for aggressive periodontitis in Chinese patients, while the opposite genotype and allele were found to be associated with severe CP (Wang et al, 2009a). These evidences were consistent with our findings, which indicated that the association between VDR TaqI variants and periodontitis might be due to not only the ethnic background, regions, and sample size, but also the difference in mechanisms between CP and AP.…”

Section: Discussionsupporting

confidence: 88%

“…After screening the titles and abstracts, 48 articles were excluded according to the exclusion criteria outlined earlier. Of the 15 potentially relevant articles (Tachi et al, 2001;Ma, 2002;Sun et al, 2002;Li et al, 2008;Wang, 2009;Yang et al, 2009;Zhang et al, 2005Zhang et al, , 2010Zhang et al, , 2011Shao, 2013;Wang et al, 2009aWang et al, ,b, 2013Cao et al, 2015;Wu et al, 2015) identified for full study retrieval, five studies (Tachi et al, 2001;Ma, 2002;Wang, 2009;Wang et al, 2009b;Yang et al, 2009) were excluded due to duplication; two studies were excluded due to lack of controls or genotype data (Wang et al, 2013;Cao et al, 2015). Finally, eight articles (including 9 case-control studies) (Sun et al, 2002;Li et al, 2008;Wang et al, 2009a;Zhang et al, 2005Zhang et al, , 2010Zhang et al, , 2011Shao, 2013;Wu et al, 2015) met the inclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the link between Vitamin D receptor TaqI gene polymorphism and periodontitis: a meta-analysis in a Chinese population

2016

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ABSTRACT. Although a number of studies have been conducted to determine the association between vitamin D receptor (VDR) TaqI polymorphism and periodontitis in the Chinese population, this association remains elusive. To assess the influence of VDR TaqI polymorphism on the risk of periodontitis, a meta-analysis was performed in a Chinese population. Relevant studies were identified using the databases PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine, through January 2016. Pooled odds ratios and 95% confidence intervals were used to assess the strength of the associations. This meta-analysis identified 9 studies, which included 1014 periodontitis cases and 907 controls. In both overall and subgroup analyses, VDR TaqI polymorphism was not associated with the risk of periodontitis. Cumulative analysis also suggested a lack of association between VDR TaqI polymorphism and the risk of periodontitis in the Chinese population. In conclusion, our meta-analysis showed that VDR TaqI polymorphism is not associated with the risk of periodontitis in the Chinese population. Further studies in other ethnic groups are required for definite conclusions.

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“…An Abf haplotype containing rs2228570 has been reported to confer an elevated risk of severe CP in Japanese men (Naito et al, 2007), while several other studies found no significant association between rs2228570 and CP susceptibility (Tachi et al, 2003;Wang et al, 2009;Chen et al, 2012;Tanaka et al, 2013). No significant association was found in a previous meta-analysis of 15 studies including 1338 cases and 1302 controls between rs2228570 and CP (Chen et al, 2012).…”

Section: Discussionmentioning

confidence: 91%

Lack of association between the vitamin D receptor polymorphism rs2228570 and chronic periodontitis in a Han Chinese population

Wang

Chen

2015

Genet. Mol. Res.

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ABSTRACT. The vitamin D receptor (VDR) is involved in the immune response and bone metabolism, both of which are implicated in the pathogenesis of chronic periodontitis (CP). In this study, we investigated the association between the VDR single nucleotide polymorphism rs2228570 and CP susceptibility in a Han Chinese population consisting of 440 moderate or severe CP patients and 324 controls. Genomic DNA was extracted from buccal epithelial cells and genotyped using matrix-assisted laser desorption/ ionization time-of-flight-mass spectrometry. No significant difference in allelic or genotypic frequencies distributions for rs2228570 was found between CP patients and controls. In conclusion, we found no statistically significant association between rs2228570 and CP in our population.

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Association Between Vitamin D Receptor Gene Polymorphisms and Severe Chronic Periodontitis in a Chinese Population

Abstract: TaqI SNP of VDR gene might be associated with severe CP in Chinese patients.

Cited by 46 publications

References 36 publications

Vitamin D: relevance in dental practice

Vitamin D: relevance in dental practice

Assessment of the link between Vitamin D receptor TaqI gene polymorphism and periodontitis: a meta-analysis in a Chinese population

Lack of association between the vitamin D receptor polymorphism rs2228570 and chronic periodontitis in a Han Chinese population

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