Association between vitamin D receptor polymorphisms and multiple sclerosis: systematic review and meta-analysis of case–control studies

Abstract

Vitamin D receptor (VDR) polymorphisms have been studied as potential contributors to multiple sclerosis (MS). However, published studies differ with respect to study design and the significance of the effects detected. The aim of this study was to quantify the magnitude of the risk associated with the TaqI, BsmI, ApaI and FokI VDR polymorphisms in MS using a meta-analysis approach. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a systematic search and meta-analysis of the literature. Subgroup analyses were performed to detect potential sources of heterogeneity from the selected study characteristics. The stability of the summary risk was evaluated using sensitivity analyses. The meta-analysis included a total of 3300 cases and 3194 controls from 13 casecontrol studies. There were no significant associations found between TaqI and BsmI polymorphisms and MS risk. The association between the ApaI polymorphism and MS risk was significant in the homozygous and codominant models (P50.013 and P50.031, respectively), suggesting that the AA ApaI genotype might be a significant MS risk factor. Publication year and age significantly affected the association between TaqI polymorphisms and MS (P50.014 and P50.010, respectively), which indicates a protective effect of the major T allele. The AA ApaI and FF FokI genotypes are significant risk factors for MS. The association between the TaqI polymorphism and MS risk is significantly affected by study characteristics.

Predisposing role of vitamin D receptor (VDR) polymorphisms in the development of multiple sclerosis: A case-control study

“…There are several studies that have shown results consistent with the present work. The observations of the current study have confirmed that of some studies [17,27,28] and not all [29,30]. Genotyping results of BsmI (A/C), the second studied SNP, disclosed that allele A and homozygote AA genotype are correlated with MS.…”

“…Consistent with the present study, other investigations have shown a strong association between BsmI variant and MS disease [31][32][33]. Nevertheless, in contrast to the present findings, other reports have declared no relationship between BsmI and MS [16,28,30].…”

Risk factors for multiple sclerosis and associations with anti-EBV antibody titers

“…Low vitamin D (25(OH)D) level is another risk factor for developing MS, and many studies have found an association between vitamin D deficiency and MS development, disability progression (or EDSS) [26][27][28], and increasing numbers of Gadolinium-enhancing lesions on MRI [29]. It was reported that vitamin D supplementation could decrease inflammatory cytokine production of CD8 + T cells in MS patients [30].…”

Significance of Gene Polymorphism of Vitamin D Receptor in Human Pathology

“…Относительно АpaI полиморфизма гена VDR показано, что генотипы АА и АС встречались несколько чаще у больных рассеянным склерозом (р=0,013 и p=0,031 соответственно), чем у здоровых лиц, это несколько противоречит данным предыду-щего исследования. При исследовании ассоциации полиморфизма FokI определено, что генотип СС является значимым фактором риска рассеянного склероза [4].…”

“…Относительно АpaI полиморфизма гена VDR показано, что генотипы АА и АС встречались несколько чаще у больных рассеянным склерозом (р=0,013 и p=0,031 соответственно), чем у здоровых лиц, это несколько противоречит данным предыду-щего исследования. При исследовании ассоциации полиморфизма FokI определено, что генотип СС является значимым фактором риска рассеянного склероза [4].По результатам другого метаанализа (2012), вклю-чавшего 2599 пациентов и 2816 лиц контрольной группы из 11 исследований, не выявлено связи меж-ду ApaI, BsmI, FokI, TaqI полиморфизмами гена VDR и рассеянным склерозом [5]. По данным исследова-ний С.А.…”