Association between vitamin D level in mother’s serum and the level of vitamin D in the serum of pre-term infants

Motlagh, Alireza Jashni; Davoodvandi, Ahmadreza; Saeieh, Sara Esmaelzadeh

doi:10.1186/s12887-023-03854-0

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…In our study, newborns' serum vitamin D levels in both the opioid and non-opioid groups participating were found to be deficient (< 20 ng/ml) (25). This finding was attributed to inadequate nutrition and lack of vitamin D supplementation due to poor prenatal care, preterm birth, and low socioeconomic status associated with unemployment.…”

Section: Discussionmentioning

confidence: 54%

Prenatal Substance Abuse: a 1-Year Single-Center Experience at a Tertiary Neonatal Intensive Care Unit

DOĞAN,

SALİHOĞLU

2023

Türkiye Çocuk Hast Derg

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Objective: Eight newborns diagnosed with prenatal substance abuse were evaluated for the clinical course of neonatal abstinence syndrome depending on the type of substances used by their mothers during pregnancy. Material and Methods: A retrospective study of neonates with prenatal substance abuse admitted to our tertiary care university hospital’s Neonatal Intensive Care Unit (NICU) was conducted between February 2022 and March 2023. Demographic data, withdrawal symptoms, need for pharmacological treatment, and duration of hospitalization were collected. Newborns exposed to substances were divided into two groups: opioid and non-opioid (methamphetamine, Bonsai, marijuana). Results: Eight infants were included in the study. Four cases (50%) were in the group exposed to opioids. Pregnant users of opioids were older (28±6.73) than non-opioid substance users (21±4.83). The mean birth weight of newborns exposed to opioids (2541 g) was lower than that of the non-opioid group (3020 g). The average length of hospital stay was longer in the opioid group (34 days) compared to the non-opioid group (10 days). All newborns exposed to substances were born preterm (<37 gestational weeks). Withdrawal symptoms were observed in all cases in the opioid group and three cases in the non-opioid group to varying degrees. Medical treatment was required in three out of the seven cases with withdrawal symptoms. All patients requiring treatment were in the opioid group. All infants were discharged in good health. Conclusion: Substance exposure during the prenatal period is a significant cause of preterm birth in neonates. Many of these substances can cause varying degrees of withdrawal syndrome in newborns. Replacement therapies used during pregnancy containing heroin and naloxone can lead to a more severe, prolonged, and treatment-requiring neonatal withdrawal syndrome than other substances. In cases where morphine and methadone are unavailable, the symptoms of withdrawal syndrome can be managed with phenobarbital. It is crucial to monitor all newborns with prenatal exposure to substances early because it allows for appropriate intervention and treatment.

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Section: Discussionmentioning

confidence: 54%

Prenatal Substance Abuse: a 1-Year Single-Center Experience at a Tertiary Neonatal Intensive Care Unit

DOĞAN,

SALİHOĞLU

2023

Türkiye Çocuk Hast Derg

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“…Many studies have demonstrated that low levels of VD during pregnancy can result in low levels of VD in premature infants after they are born. [24][25][26] According to Milan et al, 27 GDM patients had lower serum VD levels and serum VD was negatively correlated with their fasting blood glucose levels. Additionally, higher expression of genes linked to VD resistance was seen in GDM patients, and this expression was inversely correlated with serum VD levels.…”

mentioning

confidence: 99%

Vitamin D Status of Preterm Newborns at Approximately 4 Weeks of Age in Shenzhen, China: A Retrospective Observational Cohort Study Conducted Across Two Centers

Guo,

Yu,

et al. 2024

RRN

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Background and Objectives:To examine the correlation between the concentration of vitamin D (VD) in venous blood at approximately 4 weeks of age (±4 weeks of age) and neonatal outcomes in preterm infants (birth weight <1500 g or gestational age <32 weeks) in two neonatal intensive care units (NICUs) located in Shenzhen, China. Methods and Study Design: Preterm infants were split into two groups based on their VD concentration at ±4 weeks of age: VD insufficiency (VDI) group (≤20 ng/mL) and VD sufficient (VDS) group (>20 ng/mL). Binary logistic regression analysis was used to examine relationships between outcomes and VDI. Results: Of 230 infants in total, 119 (51.7%) were assigned to the VDI group and 111 to the VDS group (48.3%). No correlation was found between serum VD at ±4 weeks of age and gestational age (p>0.05). The starting point of the two groups for oral VD intake did not differ significantly (p>0.05). At ±4 weeks of age, oral VD dose (P<0.05) was greater in the VDS group. Gestational diabetes mellitus was associated with VDI (OR=1.94, 95% CI 1.01-3.75, p=0.047) after controlling for this risk. Following correction for gestational age and oral VD dosage at ±4 weeks old, VDI was also linked to a significant risk of retinopathy of prematurity (OR=2.00, 95% CI 1.08-3.68, p<0.027). Conclusion: Preterm newborns (gestational age <32 weeks or birth age <1500 g) in NICUs in Shenzhen, China continue to have significantly high VDI. Higher VDI is associated with gestational diabetes mellitus and retinopathy of prematurity.

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“…According to studies, the prevalence of VDD in the general population is very important and pregnancy is one of the known risk factors (RFs) for this deficiency, and in general VDD has been reported between 47 and 83% in black and white pregnant women respectively [16]. Vitamin D status in the fetus and newborn is largely determined by the vitamin D status of the mother [16]. Since VDD is prevalent in mothers, many infants are also at risk of deficiency and insufficiency of vitamin D levels [16].…”

mentioning

confidence: 99%

“…Vitamin D status in the fetus and newborn is largely determined by the vitamin D status of the mother [16]. Since VDD is prevalent in mothers, many infants are also at risk of deficiency and insufficiency of vitamin D levels [16]. Τherefore, when we assume that mothers will suffer much more from VDD, during the corona period, due to theoretically less sun exposure that deteriorate vitamin D synthesis to the skin, with the same rationale we imagine that newborns will suffer the same, due to the quarantine and restrictions on movement from home.…”

mentioning

confidence: 99%

The possible impact of COVID-19 pandemic on serum vitamin D levels on newborns in Greece

Artemisia Kokkinari,

Maria Dagla,

Aikaterini Lykeridou

et al. 2023

World J. Adv. Res. Rev.

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Background: Very few studies have evaluated the probable role of the period of 2019 coronovirus disease (COVID-19) pandemic on neonatal 25(OH)D levels. Vitamin D status in the fetus and newborn is largely determined by the vitamin D status of the mother. A recent study in Greece witnessed an unexpected rise in maternal 25(OH)D levels in pregnancy during the COVID-19 period. Consequently, it remains unclear whether neonatal 25(OH)D levels decreased due to reduced sun exposure in the COVID-19 period or followed their unexpected maternal findings. Methods: We studied neonatal 25(OH)D levels in cord blood specimens at birth in 246 neonates of Greek mothers with stratified random sampling, from September 2019 to January 2022. We divided our samples into the pre-COVID-19 period and the post-COVID-19 period. Chi-square test was used to find an association between neonatal 25(OH)D concentrations throughout the COVID-19 period. Quantitative results of 25(OH)D vitamin levels on newborns were transformed into qualitative variables assessing lack of 25(OH)D, adequacy, deficiency and severe deficiency and thus defined in that way. All other results of 25(OH)D levels are presented as means ± standard deviations (SD) or by frequencies and percentages. Results: The results in neonates exhibited a similar pattern to that of their mothers’. The mean serum values of 25(OH)D levels of the newborns were statistically significantly higher during the COVID-19 period compared to the pre-COVID-19 period. Conclusions: Although during the COVID-19 period lower maternal and therefore neonatal 25(OH)D levels were expected, these were higher and because of these findings, we can only make assumptions. Without a doubt, further investigation is required.

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Association between vitamin D level in mother’s serum and the level of vitamin D in the serum of pre-term infants

Cited by 6 publications

References 32 publications

Prenatal Substance Abuse: a 1-Year Single-Center Experience at a Tertiary Neonatal Intensive Care Unit

Prenatal Substance Abuse: a 1-Year Single-Center Experience at a Tertiary Neonatal Intensive Care Unit

Vitamin D Status of Preterm Newborns at Approximately 4 Weeks of Age in Shenzhen, China: A Retrospective Observational Cohort Study Conducted Across Two Centers

The possible impact of COVID-19 pandemic on serum vitamin D levels on newborns in Greece

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