Association between vitamin D level and community-acquired late-onset neonatal sepsis

Bilgin, Betül Siyah; Gönülal, Deniz

doi:10.5546/aap.2020.eng.265

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…Some studies believed that vitamin D played an anti-inflammatory effect in placental tissue through vitamin D receptors, thereby protecting the normal growth and development of the fetus, and low vitamin D levels would increase the risk of neonatal sepsis. [ 28 , 29 ]…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency in pregnant women

Chen

2021

Medicine

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Objective:To analyze the level of vitamin D and its influencing factors in pregnant women, and to explore the influence of vitamin D deficiency on common adverse pregnancy outcomes in pregnant women, providing evidence for prevention and intervention of vitamin D deficiency in pregnant women.Methods:The basic data and blood samples of pregnant women in our hospital from January 2019 to June 2020 were collected, and the 25-(OH) D levels of the serum samples were detected. Then the vitamin D levels and its influencing factors were analyzed, and the relationships between vitamin D levels and common adverse pregnancy outcomes in the pregnant women as well as the incidence of small-for-gestational-age newborns were analyzed.Results:The vitamin D deficiency rate, insufficiency rate and sufficiency rate of pregnant women were 83.28%, 15.36%, and 1.36% respectively, with vast majority of the pregnant women in a state of vitamin D deficiency. Analysis of the influencing factors on the vitamin D level of pregnant women showed “28 weeks ≤ gestational age ≤32 weeks, summer and autumn, high school education and above, weekly time outdoors ≥10 hours, supplement of vitamin D and trace elements during pregnancy” were protective factors for vitamin D sufficiency in pregnant women. Linear correlation analysis showed the vitamin D level of pregnant women was highly positively correlated with temperature, the higher the temperature, the higher the vitamin D level (r = 0.907, t = 6.818, P < .001). The level of vitamin D in pregnant women was related to the occurrence of spontaneous abortion and small-for-gestational age (SGA), with the incidence of spontaneous abortion and SGA in the “vitamin D deficiency group” higher than those of other groups (P = .018, P = .016).Conclusions:The vitamin D level of pregnant women in this area is relatively low, which is affected by multiple factors such as gestational age, season, education level of pregnant women, weekly time outdoors, vitamin D and trace element supplement during pregnancy. Low vitamin D levels can increase the risk of spontaneous abortion and SGA in pregnant women, so relevant measures should be adopted to improve the vitamin D status of pregnant women.

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Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency in pregnant women

Chen

2021

Medicine

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“… 4 , 5 , 6 Vitamin D has powerful antibacterial and anti‐inflammatory properties, and vitamin D deficiency has been shown to be related to the risk of susceptibility to different infectious diseases (such as neonatal sepsis). 7 , 8 A meta‐analysis of the association between vitamin D status in children and sepsis found a significant association between vitamin D deficiency and sepsis in children and newborns. 9 Siyah et al 7 found that compared with the control group, full‐term infants with late‐onset sepsis and their mothers had lower levels of 25‐hydroxyvitamin D. Vitamin D receptor gene polymorphism can affect individual vitamin D expression.…”

Section: Introductionmentioning

confidence: 99%

“… 7 , 8 A meta‐analysis of the association between vitamin D status in children and sepsis found a significant association between vitamin D deficiency and sepsis in children and newborns. 9 Siyah et al 7 found that compared with the control group, full‐term infants with late‐onset sepsis and their mothers had lower levels of 25‐hydroxyvitamin D. Vitamin D receptor gene polymorphism can affect individual vitamin D expression. 10 , 11 VDR is found in almost all immune cells, and some of its polymorphisms are found to be related to the increased incidence of autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

The relationship between vitamin D receptor gene and TREM‐1 gene polymorphisms and the susceptibility and prognosis of neonatal sepsis

Que

et al. 2022

Clinical Laboratory Analysis

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Neonatal sepsis is the main cause of death of newborns, especially premature infants. According to the statistics of epidemiology, the incidence rate of full-term infants is about 1%, the incidence rate of very low birth weight infants is as high as 20%, the mortality rate of early-onset sepsis is 13%, and the mortality rate of late-onset sepsis is 8.9%, which is extremely low, the mortality rate of very low birth weight infants can reach more than 20%. [1][2][3] In recent years, with the completion of the Human Genome Project and the development of

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Association between vitamin D level and community-acquired late-onset neonatal sepsis

Cited by 2 publications

References 23 publications

Vitamin D deficiency in pregnant women

Vitamin D deficiency in pregnant women

The relationship between vitamin D receptor gene and TREM‐1 gene polymorphisms and the susceptibility and prognosis of neonatal sepsis

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