Association Between Vitamin D, Frailty, and Progression of Frailty in Community-Dwelling Older Women

Abstract

Context Vitamin D (25OHD) is involved in many physiological functions that decline with age, contributing to frailty and increased risk for negative health outcomes. Whether 25OHD is a long-term risk marker for frailty over a longer time and whether it is consistent with advancing age is unclear. Objective To investigate the association between 25OHD and frailty in older women followed for 10 years. Design and Setting Prospective, population-based, cohort study in Malmö, Sweden. Participants Community-dwelling women, age 75 years (N = 1044) with reassessments at ages 80 (n = 715) and 85 (n = 382) years. Methods Frailty was quantified using a 10-variable frailty index. Women were categorized as 25OHD insufficient (<50 nmol/L) or sufficient (≥50 nmol/L). Results At ages 75 and 80 years, women with insufficient 25OHD were frailer than women with sufficient 25OHD (0.23 vs 0.18, P < 0.001; and 0.32 vs 0.25, P = 0.001, respectively). At age 80 years, 25OHD insufficiency was associated with subsequent frailty 5 years later (0.41 vs 0.32; P = 0.011). Accelerated progression of frailty was not associated with lower 25OHD levels, and 25OHD level >75 nmol/L was not additionally beneficial with regard to frailty. No association between 25OHD and frailty was observed at age 85 years. Within the frailty index, variables associated with 25OHD were related to muscle strength and function. Conclusion In this study, 25OHD insufficiency was associated with increased frailty in all but the oldest old. This study supports the value of maintaining sufficient 25OHD levels for healthy aging.

Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice

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Screening for and Managing the Person with Frailty in Primary Care: ICFSR Consensus Guidelines

“…Although less studied, other clinical interventions such as nutrition may offer benefits to older adults with frailty in outpatient settings. Observational studies suggest potential benefits of the Mediterranean diet ( 61 , 62 ) and of vitamin D supplementation in patients that are deficient ( 63 , 64 ). A summary of these recommendations can be seen in Table 2 .…”

Frailty and prediction of recurrent falls over 10 years in a community cohort of 75-year-old women

“…However, since the cohort was designed to investigate bone health, not general health, in aging, this was impossible. Instead, following the rules of Searle et al [ 20 ] we developed a frailty index which performs well [ 16 , 17 ]. Second, one of the variables included in the index was ‘self-estimated fall risk’, since the index was constructed for use with multiple outcomes.…”

“…The OPRA cohort consists of 75-year-old community-dwelling women (75.2 ± 0.2) as described in detail [ 17 ]. N = 1044 attended baseline.…”

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