Association between vitamin D deficiency and sepsis in pediatric ICU

El-Gendy, Fady M; Khattab, Ahmed A.; Naser, Rehab G; Abdel-Aziz, Aliaa A

doi:10.4103/mmj.mmj_210_19

Cited by 6 publications

(3 citation statements)

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“…In agreement with our results El-Gendy et al revealed that the levels of 25(OH)D in individuals with sepsis accepted to PICU were lower than in pediatric controls (16.61±8.46 vs. 23.15±8.57 ng/ml respectively; P = 0.001) (18) . The PRIM III score is one of the scoring systems that is frequently utilized to quantify critical disease in the pediatric age and provide an objective evaluation of the degree to which a person is under the influence of illness (19) .…”

Section: Discussionsupporting

confidence: 93%

“…Regarding the relation amongst PRISM III and Serum 25(OH)D, our research demonstrated that was noted a statistically significant negative correlation amongst PRISM III and Serum 25(OH)D (ng/ml) (p<.001).In line with our research El-Gendy et al noted a significant negative correlation amongst vitamin D level and PRISM III score (P = 0.02), CV-SOFA score (P = 0.001), duration of ventilation (P = 0.003) and PICU stay (P < 0.001) (18) . On the other hand, Ibrahim et al did not found any significant association amongst 25(OH) vitamin D and the PRISM III, the requirement for mechanical ventilation or the use of inotropes.…”

Section: Discussionsupporting

confidence: 89%

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Association of vitamin D level and pediatric risk of mortality III score in critically ill children

Aboassy,

Handoka,

Badr

2024

Medicine Updates

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Background: Twenty-five hydroxy vitamin D is an essential nutrient that is made up of a combination of fat-soluble secosteroids and has a key role in the endocrine system additionally there is evidence that low vitamin d level is associated with increased fatality rate. Aim: Our research aimed to investigate the association amongst critically ill Children`s vitamin 25(OH)D levels and their illness severity measured by PRISM III scores. Patients and methods: This casecontrol research was performed on 30 children with critical illness admitted to the ICU of Pediatric of El-Salam Port-Said General Hospital in addition to 30 healthy children as the control group. Results: In the patients group (n=30), the PRISM III ranged from 5 to 24, with a median of 9.00, a 95% of the CI of the median of 7.00-15.00, and 25th Percentile -75th Percentile of 6.00-15.00. It was noted no statistically significant variance in PRISM III Score amongst the individuals with different diagnosis (p=0.053). The PRISM III Score was significantly greater in the deceased individuals relative to the discharged individuals (p=0.005),a statistically significant association is noted amongst PRISM III and Serum 25(OH)D (ng/ml) (p<0.001). Conclusion:.low serum 25(OH)D was correlated with higher PRISM III score.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Association of vitamin D level and pediatric risk of mortality III score in critically ill children

Aboassy,

Handoka,

Badr

2024

Medicine Updates

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“…22,23 These findings were further confirmed by several randomized clinical trials (RCTs) that reported the protective effect of VD supplementation in reducing the risk of acute respiratory infections by 25% at doses of 400-1000 IU per day for 12 months, particularly in those with a baseline of <25 nmol/l. 24,25 During sepsis, there is growing evidence that VD deficiency is strongly associated with sepsis risk, pathogenesis, and outcomes as described later, [26][27][28][29] but to date, these data could not be applied clinically. Several clinical trials aimed at analyzing the effects of supplementing VD on the outcomes of critical illness including sepsis have reported contradictory results as shown in Table 1.…”

Section: Introductionmentioning

confidence: 99%

A Potential Role of Vitamin D on Platelet Leukocyte Aggregation and Pathological Events in Sepsis: An Updated Review

Alharbi¹

2021

JIR

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Vitamin D deficiency and sepsis are both significant global health problems. Insufficient vitamin D is considered to be a pathogenically relevant factor of sepsis-related deaths; however, a causal relationship has not yet been demonstrated. Recently, vitamin D has been an exciting field of research owing to the identification of vitamin D receptors on many extra skeletal tissues and cells, suggesting an unexpected role on body physiology, beyond its effects on bone homeostasis. However, while the role of vitamin D on bone health is widely understood and has been successfully translated into clinical applications and public health policies, recent evidence supporting its role in other physiological and pathological processes has not been fully established. In sepsis, there is an induction of local intracellular vitamin D activity by most immune cells, including lymphocytes, macrophages, neutrophils, and dendritic cells, as well as vascular endothelial cells, to ensure efficient clearance of infective microorganisms and mediate anti-inflammatory and tolerogenic effects. The literature suggests an association between low vitamin D levels and sepsis, but clinical trials have yielded contradictory results. A greater understanding of this role may improve disease management. This article reviews the available knowledge regarding vitamin D in immune function, emerging literature regarding the association between its deficiency and sepsis, as well as presenting its potential effect on platelet leukocyte aggregations (PLAs), a significant pathology in sepsis. It also summarizes clinical trials involving vitamin D supplementation during critical illness and sepsis and addresses the impact of relevant factors of sepsis pathogenesis on the efficacy of vitamin D supplementation, which could contribute to the reported inconsistencies. Looking ahead, further studies are required to uncover the possible modulatory relationship between vitamin D and sepsis to define better cut-offs for its levels, proper timing of its administration, and the optimum dosage for best management.

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Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial

O’Hearn,

Menon,

Albrecht

et al. 2024

Trials

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Association between vitamin D deficiency and sepsis in pediatric ICU

Cited by 6 publications

References 0 publications

Association of vitamin D level and pediatric risk of mortality III score in critically ill children

Association of vitamin D level and pediatric risk of mortality III score in critically ill children

A Potential Role of Vitamin D on Platelet Leukocyte Aggregation and Pathological Events in Sepsis: An Updated Review

Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial

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