Association between vitamin B₁₂intake and EURRECA's prioritized biomarkers of vitamin B₁₂in young populations: a systematic review

Abstract

Objective: To review evidence on the associations between vitamin B 12 intake and its biomarkers, vitamin B 12 intake and its functional health outcomes, and vitamin B 12 biomarkers and functional health outcomes. Design: A systematic review was conducted by searching electronic databases, until January 2012, using a standardized strategy developed in the EURRECA network. Relevant articles were screened and sorted based on title and abstract, then based on full text, and finally included if they met inclusion criteria. A total of sixteen articles were included in the review. Setting: Articles covered four continents: America (n 4), Europe (n 8), Africa (n 1) and Asia (n 3). Subjects: Population groups included healthy infants, children and adolescents, and pregnant and lactating women. Results: From the total number of 5815 papers retrieved from the initial search, only sixteen were eligible according to the inclusion criteria: five for infants, five for children and adolescents, and six for pregnant and lactating women. Conclusions: Only one main conclusion could be extracted from this scarce number of references: a positive association between vitamin B 12 intake and serum vitamin B 12 in the infant group. Other associations were not reported in the eligible papers or the results were not provided in a consistent manner. The low number of papers that could be included in our systematic review is probably due to the attention that is currently given to research on vitamin B 12 in elderly people. Our observations in the current systematic review justify the idea of performing well-designed studies on vitamin B 12 in young populations.

Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12)

“…In a systematic review on the associations between cobalamin intake and biomarkers in children (Iglesia et al, 2013), one cross-sectional study was identified which examined dietary intake of cobalamin and serum cobalamin, holoTC, MMA and tHcy concentrations in 155 healthy, non-breastfed Norwegian toddlers at 24 months of age (Hay et al, 2011). Seven-day weighed food records were used for cobalamin intake assessment.…”

The Disparate Roles of Cobalt in Erythropoiesis, and Doping Relevance

“…The common view is that cobalamin deficiency is more likely to occur when IF-driven absorption fails (pernicious anemia) than when diet is poor (vegetable diet). However, attention has been restricted to elderly people, while there is a lack of information on vitamin B 12 deficiency in young populations [24]. One study has shown that 40% of vegetarians presented with lower blood Hb concentration, hematocrit, mean corpuscular Hb mass and serum cobalamin levels than the control subjects [48].…”

Validação de um questionário semiquantitativo de frequência alimentar e de seu Índice de Qualidade da Dieta Revisado para crianças e adolescentes de 9 a 13 anos utilizando biomarcadores dietéticos - Ribeirão Preto, SP

“…No entanto, ela é influenciada por diversos fatores, tal como massa muscular, e sua confiabilidade como biomarcador precisa ser mais bem determinada227 . Os componentes Vegetal total SL e Veveal SL apresentaram ainda De fato, as concentrações plasmáticas de vitaminas do complexo B não são relacionadas apenas ao consumo dos alimentos fontes, mas também aos padrões alimentares237,238 . Além das correlações positivas encontradas entre componentes do IQD-R considerados fontes de vitaminas do complexo B e seus biomarcadores, correlações negativas foram encontradas entre esses e os componentes Carne, ovos e leguminosas, Gordura saturada e Cereal total.…”