Association between Vitamin B and Obesity in Middle-Aged and Older Chinese Adults

Fu, Yu; Zhu, Zhanyong; Huang, Zhaolan; He, Ruikun; Zhang, Ying; Li, Yuanyuan; Tan, Wei; Rong, Shuang

doi:10.3390/nu15030483

Cited by 9 publications

(7 citation statements)

References 34 publications

(38 reference statements)

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“…(3) SLC25A19 . The protein encoded by the SLC25A19 gene was a member of the solute carrier family and was involved in vitamin B 1 metabolism process, while the vitamin B 1 level was reported to be negatively related to obesity (Fu et al, 2023). Moreover, the vitamin B 1 deficiency was also related to some cardiovascular traits, such as elevated cardiac stroke volume, decreased vascular resistance, and elevated pressor responses, suggesting a possible role in influencing BP levels (DiNicolantonio et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

DNA Methylation Mediated the Association of Body Mass Index With Blood Pressure in Chinese Monozygotic Twins

Yao,

Ning,

Wang

et al. 2024

Twin Res Hum Genet

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Obesity is an established risk factor for hypertension, but the mechanisms are only partially understood. We examined whether body mass index (BMI)-related DNA methylation (DNAm) variation would mediate the association of BMI with blood pressure (BP). We first conducted a genomewide DNA methylation analysis in monozygotic twin pairs to detect BMI-related DNAm variation and then evaluated the mediating effect of DNAm on the relationship between BMI and BP levels using the causal inference test (CIT) method and mediation analysis. Ontology enrichment analysis was performed for CpGs using the GREAT tool. A total of 60 twin pairs for BMI and systolic blood pressure (SBP) and 58 twin pairs for BMI and diastolic blood pressure (DBP) were included. BMI was positively associated with SBP (β = 1.86, p = .0004). The association between BMI and DNAm of 85 CpGs reached p < 1×10–4 level. Eleven BMI-related differentially methylated regions (DMRs) within LNCPRESS1, OGDHL, RNU1-44P, NPHS1, ECEL1P2, LLGL2, RNY4P15, MOGAT3, PHACTR3, and BAI2 were found. Of the 85 CpGs, 9 mapped to C10orf71-AS1, NDUFB5P1, KRT80, BAI2, ABCA2, PEX11G and FGF4 were significantly associated with SBP levels. Of the 9 CpGs, 2 within ABCA2 negatively mediated the association between BMI and SBP, with a mediating effect of −0.24 (95% CI [−0.65, −0.01]). BMI was also positively associated with DBP (β = 0.60, p = .0495). The association between BMI and DNAm of 193 CpGs reached p < 1×10−4 level. Twenty-five BMI-related DMRs within OGDHL, POU4F2, ECEL1P2, TTC6, SMPD4, EP400, TUBA1C and AGAP2 were found. Of the 193 CpGs, 33 mapped to ABCA2, ADORA2B, CTNNBIP1, KDM4B, NAA60, RSPH6A, SLC25A19 and STIL were significantly associated with DBP levels. Of the 33 CpGs, 12 within ABCA2, SLC25A19, KDM4B, PTPRN2, DNASE1, TFCP2L1, LMNB2 and C10orf71-AS1 negatively mediated the association between BMI and DBP, with a total mediation effect of −0.66 (95% CI [−1.07, −0.30]). Interestingly, BMI might also negatively mediate the association between the DNAm of most CpG mediators mentioned above and BP. The mediating effect of DNAm was also found when stratified by sex. In conclusion, DNAm variation may partially negatively mediate the association of BMI with BP. Our findings may provide new clues to further elucidate the pathogenesis of obesity to hypertension and identify new diagnostic biomarkers and therapeutic targets for hypertension.

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Section: Discussionmentioning

confidence: 99%

DNA Methylation Mediated the Association of Body Mass Index With Blood Pressure in Chinese Monozygotic Twins

Yao,

Ning,

Wang

et al. 2024

Twin Res Hum Genet

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“…Other studies have shown that blood releases a significant amount of ionized Mg 2+ during coagulation; therefore, the concentration of whole-blood magnesium detected using dry blood spots was lower than that in the serum [ 27 ]. Although, DBS-LC-MS/MS has been used specifically to store and measure a variety of minerals, including magnesium [ 28 , 29 ], and previous studies have proved the accuracy of DBS-LC-MS/MS [ 30 , 31 ]. Whether the above explanations are the reasons for the difference in study results still needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Whole-Blood Magnesium and Cognitive Performance among Chinese Adults

He²,

Zhang³

et al. 2023

Nutrients

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Objective: To explore the association between magnesium levels and the odds of mild cognitive impairment (MCI). Method: In this cross-sectional study of 1006 participants (≥55 years) from China, whole-blood magnesium concentration was measured using inductively coupled plasma mass spectrometry. MCI was diagnosed according to Petersen criteria using self-reported cognitive decline and a neuropsychological test battery, including the trail-making test-part B (TMT-B), auditory verbal learning test (AVLT), digit symbol substitution test (DSST), and verbal fluency test (VFT), which measured the assessment of executive, memory, attention, and language functioning, respectively. A logistic regression was used to assess the relationship between magnesium levels and MCI, and linear regression analyses were performed for the association between magnesium and cognitive function score. Results: The MCI group had a significantly lower concentration of magnesium compared to the Non-MCI group (34.7 ± 9.8 vs. 36.7 ± 9.7, p = 0.017). After adjusting for covariates, a negative association was observed between magnesium levels and MCI. Compared with the lowest quartile (median: 25.4 mg/L), the odds ratio for MCI was 0.53 (95%CI 0.32–0.90) for the highest quartile (median: 48.4 mg/L), and there was an inverse dose–response relationship (p for trend = 0.009). In addition, higher levels of magnesium were positively correlated with VFT scores (β = 0.37, 95%CI = 0.11–0.62) and DSST scores (β = 0.50, 95%CI = 0.01~0.98) and negatively correlated with TMT scores (β = −1.73, 95%CI = −3.40–−0.07) in the middle-aged and older adults. Conclusions: Whole-blood magnesium was inversely associated with the occurrence of MCI and positively associated with performance in neuropsychological tests assessing attention, executive, and language ability in middle-aged and older adults.

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“…Surprisingly, a recent meta-analysis by Eitmann et al demonstrated that the age-dependent impact of additional obesity on all-cause mortality in sarcopenic people results in lower mortality risk in older adults, i.e., the obesity paradox [ 91 ]. It has been reported that circulating B6 levels were negatively related to obesity in middle-aged and older adults [ 92 , 93 ]. Additionally, B6 status in obese adults was positively associated with health consequences [ 17 , 34 ].…”

Section: Outlook For Future Researchmentioning

confidence: 99%

Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review

Kato,

Kimoto,

Zhang

et al. 2024

Nutrients

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Marginal vitamin B6 (B6) deficiency is a widespread global concern. Inadequate B6 levels have been linked to an increased risk of age-related chronic diseases such as cardiovascular diseases and cancers. In recent years, the growing concern over sarcopenia (the age-related loss of muscle mass and strength) and frailty (a decline in physiological resilience and increased vulnerability associated with aging) is particularly relevant due to the emergence of super-aged societies in developed countries. Notably, among the thirty-one studies included in this review, twenty-five showed a significant association of B6 status with sarcopenia, frailty, and all-cause mortality in adults (p < 0.05), while six showed no association. Emerging studies have suggested novel mechanisms underlying this association. These mechanisms involve P2X7 receptor-mediated NLRP3 inflammasome signaling, AMPK signaling, PD-L1 signaling, and satellite cell-mediated myogenesis. Furthermore, the modulation of PLP-dependent enzymes due to B6 deficiency is associated with impaired metabolic processes, affecting energy utilization, imidazole peptide production, and hydrogen sulfide production, as well as the kynurenine pathway, all of which play vital roles in skeletal muscle health and pathophysiology. This narrative review provides an up-to-date assessment of our current understanding of the potential role of nutritional B6 status in combating sarcopenia, frailty, and mortality.

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Association between Vitamin B and Obesity in Middle-Aged and Older Chinese Adults

Cited by 9 publications

References 34 publications

DNA Methylation Mediated the Association of Body Mass Index With Blood Pressure in Chinese Monozygotic Twins

DNA Methylation Mediated the Association of Body Mass Index With Blood Pressure in Chinese Monozygotic Twins

Relationship between Whole-Blood Magnesium and Cognitive Performance among Chinese Adults

Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review

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