Association between visceral adiposity index, hirsutism and cardiometabolic risk factors in women with polycystic ovarian syndrome: A cross-sectional study

Fonseka, Sanjeewani; Subhani, Brabaharan; Wijeyaratne, Chandrika; Gawarammana, Indika; Kalupahana, Nishan S.; Ratnatunga, Neelakanthi; Rosairo, Shanthini; Vithane, Kumarasiri P.

doi:10.4038/cmj.v64i3.8958

Cited by 6 publications

(4 citation statements)

References 16 publications

(26 reference statements)

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“…We noted a positive correlation of VAI with systolic BP in PCOS women. Fonseka et al have also noted this correlation [18]. In our study, increasing VAI correlated significantly with greater mean ovarian volume and antral follicle count.…”

Section: Discussionsupporting

confidence: 86%

“…It was noted that both fasting and post-prandial blood sugars correlated positively with VAI in PCOS women, a similar trend was seen with increasing VAI in non-PCOS women as well, albeit with weaker strength. An Asian study has similarly also observed a positive correlation between VAI and OGTT correlation [ 18 ]. Other authors have demonstrated that VAI correlates inversely with insulin sensitivity evaluated by the euglycemic hyperinsulinemic clamp test [ 10 ].…”

Section: Discussionmentioning

confidence: 96%

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Visceral Adiposity Index as an Indicator for Menstrual Disturbance, Hormonal and Metabolic Dysfunction in Polycystic Ovarian Syndrome

Sarkar¹,

Kaur²,

Gupta³

et al. 2022

Cureus

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Background: Increase in visceral adiposity is characteristic of polycystic ovarian syndrome (PCOS) and is the main cause of insulin resistance and hyperandrogenism. This study tried to compare the visceral adiposity index (VAI) in PCOS women and control population, thereby exploring its correlation with ovarian morphology, hormonal and metabolic dysfunction.Materials and Methods: Reproductive-age women who fulfilled the Rotterdam criteria for PCOS constituted the cases. Control population consisted of the same number of non-PCOS women. History of menstrual irregularity and features of hyperandrogenism were noted. Overnight fasting serum hormonal profile on second day of the cycle, oral glucose tolerance test (OGTT) and serum fasting insulin and lipid profile were obtained. Ultrasound evaluation was done simultaneously. Free androgen index (FAI), homeostatic model assessment of insulin resistance (HOMA-IR) and VAI were calculated.Results: Serum androgen levels and OGTT were greater in PCOS women. No significant difference was noted in serum fasting glucose, fasting insulin and lipid profile between cases and controls. Both systolic and diastolic blood pressures were significantly higher among women with PCOS. Mean ovarian volume, antral follicle count, FAI and HOMA-IR were higher in PCOS women. VAI was significantly higher in cases compared to controls. VAI demonstrated a strong negative correlation with number of menstrual cycles per year. Increasing VAI was associated with longer menstrual cycles and correlated positively with greater severity of anovulation. VAI also showed highly significant correlation with fasting blood glucose and statistically significant moderately strong positive correlation with OGTT values at two hours post glucose challenge, systolic blood pressure and mean ovarian volume. There was no demonstrable correlation between androgen levels or HOMA-IR values.Conclusion: VAI is higher in women with PCOS. It correlates positively with features of disease severity and ovarian morphology. An assessment of VAI in PCOS women could be predictive of a greater propensity for development of classical metabolic risk factors.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 96%

Visceral Adiposity Index as an Indicator for Menstrual Disturbance, Hormonal and Metabolic Dysfunction in Polycystic Ovarian Syndrome

Sarkar¹,

Kaur²,

Gupta³

et al. 2022

Cureus

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“…Exercise intensity, rather than exercise volume, seems to be the most important factor in improving health outcomes, according to a new metaanalysis. This data lends credence to the utility of exercise and it suggests that high-intensity workouts may have the largest influence on cardiorespiratory fitness, insulin resistance and body composition [28]. There was a moderate and high reduction in insulin resistance as evaluated by the HOMA-IR and body mass index (MD-0.57; 95% CI, 0.98 to 0.16 and p = 0.01; MD-1.90, 95% CI, 3.37 to 0.42 and p = 0.01) [29].…”

Section: Physical Activitysupporting

confidence: 55%

Optimizing Polycystic Ovarian Disorder (PCOD) Treatment with Personalized Lifestyle and Nutrition Strategies

Begum,

Areen

2023

JCMR

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Introduction: Polycystic Ovarian Disorder (PCOD) is a prevalent endocrine illness in women of reproductive age. It has hormonal abnormalities, irregular menstrual cycles and tiny ovarian cysts. Lifestyle and food affect PCOD development and maintenance, coupled with medical therapies. Lifestyle, diet and PCOD are interconnected in this thorough assessment. Methodology: The evaluation comprises PCOD, lifestyle, diet, exercise, stress management and nutrition research published between January 1, 2000 and May 1, 2023. Result: PCOS management requires lifestyle changes including frequent exercise, a healthy weight, nutritious diet and no cigarettes. While lifestyle modifications cannot substitute medical care, they improve well-being. Low-GI, ketogenic and omega-3 fatty acid diets may reduce insulin resistance and PCOS symptoms. Eating no Saturated Fats (SFAs) is also important. Exercise improves insulin sensitivity, but high-intensity sessions improve cardiorespiratory fitness, insulin resistance and body composition more. We propose intense aerobic and strength training. PCOS might worsen insulin resistance due to sleep disruptions. Getting enough sleep is important for metabolism. PCOS sufferers may have reduced melatonin, which regulates the body’s 24-hour schedule, underlining the significance of sleep. Vitamin D, inositol, folate, B-group vitamins, vitamin K and vitamin E may improve insulin sensitivity and hormonal balance. Vitamins including bioflavonoids, carnitine and alpha-lipoic acid and minerals like chromium picolinate, calcium, magnesium, selenium and zinc may also help PCOS sufferers. More study is required to prove their effectiveness. Conclusion: PCOD is complicated and needs comprehensive treatment. Lifestyle, food and medical therapies should be combined for best outcomes. Healthcare practitioners and PCOD patients must collaborate to create tailored lifestyle, diet and supplement recommendations. Improve these remedies for the PCOD community with further study.

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“…There was no significant association between parameters of hirsutism and the visceral adiposity index (VAI). Hirsutism is unlikely to be due to visceral adipocyte dysfunction [ 67 ]. Therefore, in PCOS patients with advanced obesity and/or obesity accompanied by full-blown metabolic syndrome, the introduction of a ketogenic diet may provide even better results than a diet with a LGI.…”

Section: Lifestyle Changesmentioning

confidence: 99%

Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review

et al. 2021

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Here we present an extensive narrative review of the broadly understood modifications to the lifestyles of women with polycystic ovary syndrome (PCOS). The PubMed database was analyzed, combining PCOS entries with causes, diseases, diet supplementation, lifestyle, physical activity, and use of herbs. The metabolic pathways leading to disturbances in lipid, carbohydrate, and hormonal metabolism in targeted patients are described. The article refers to sleep disorders, changes in mental health parameters, and causes of oxidative stress and inflammation. These conditions consistently lead to the occurrence of severe diseases in patients suffering from diabetes, the fatty degeneration of internal organs, infertility, atherosclerosis, cardiovascular diseases, dysbiosis, and cancer. The modification of lifestyles, diet patterns and proper selection of nutrients, pharmacological and natural supplementation in the form of herbs, and physical activity have been proposed. The progress and consequences of PCOS are largely modifiable and depend on the patient’s approach, although we have to take into account also the genetic determinants.

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Association between visceral adiposity index, hirsutism and cardiometabolic risk factors in women with polycystic ovarian syndrome: A cross-sectional study

Cited by 6 publications

References 16 publications

Visceral Adiposity Index as an Indicator for Menstrual Disturbance, Hormonal and Metabolic Dysfunction in Polycystic Ovarian Syndrome

Visceral Adiposity Index as an Indicator for Menstrual Disturbance, Hormonal and Metabolic Dysfunction in Polycystic Ovarian Syndrome

Optimizing Polycystic Ovarian Disorder (PCOD) Treatment with Personalized Lifestyle and Nutrition Strategies

Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review

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