Association between venous thromboembolism‐associated genetic variants, coagulation factor levels, and thrombin generation potential
Jihee Han,
Ruifang Li‐Gao,
Renée de Mutsert
et al.
Abstract:Recently three large meta‐analyses of genome‐wide association studies for venous thromboembolism (VTE) identified over 130 genetic variants. However, mechanisms by which newly identified and therefore underexplored VTE‐associated genetic variants influence VTE remain unclear. To elucidate the mechanism, we investigated the association between 61 newly identified VTE‐associated genetic variants and the levels of coagulation factor (F) VIII, FIX, FXI, and fibrinogen as well as thrombin generation parameters (lag… Show more
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