Association Between Venous Thromboembolism and Perioperative Allogeneic Transfusion

Abstract

Perioperative allogeneic blood product transfusion would be associated with venous thromboembolic complications in surgical patients.

One Intraoperative Dose of Tranexamic Acid for Patients Having Primary Hip or Knee Arthroplasty

“…In addition, because inflammation and coagulation are directly associated, any change in one may indirectly affect the other. Nilsson et al [16] found allogeneic transfusion was independently associated with a 1.5-fold increase in the risk of development of thromboembolism postoperatively. We found one 20-mg per kg intraoperative dose of TEA in our patients having primary, elective THA and TKA reduced the perioperative decrease in hemoglobin compared with a similar cohort of patients for whom the protocol was not used.…”

Aggressive Red Blood Cell Transfusion: No Association with Improved Outcomes for Victims of Isolated Traumatic Brain Injury

“…Although this complication may be a surrogate marker for a slightly sicker patient population, it is also suggestive of another potential risk with transfusion. In a recent large observational study of perioperative allogenic transfusion, venous thromboembolism was associated with transfusion in women [33]. Alternatively, longer ICULOS and higher use of paralytic drugs in the RBCT group may contribute to a higher DVD rate.…”

Cardiac Surgery and Allogeneic Blood Transfusions

“…Leukocyte-containing RBCs contain prothrombotic soluble mediators, such as CD40L, which induce the synthesis of proinflammatory mediators that can further activate the coagulation system (Blumberg et al, 2006). Observational studies showed an association between allogeneic blood transfusions and the development of venous thromboembolism (Nilsson et al, 2007 andKhorana et al, 2008). The possible association between allogeneic blood transfusions and the formation of thrombosis, as a factor aggravating MODS and having a role in increased mortality due to MODS, is a new subject and should be investigated further.…”