Association between vascular endothelial growth factor rs699947 polymorphism and the risk of three major urologic neoplasms (bladder cancer, prostate cancer, and renal cell carcinoma): A meta-analysis involving 11,204 subjects

Song, Yuxuan; Hu, Jielun; Chen, Qingke; Guo, Jia; Zou, Yixuan; Zhang, Wen; Chen, Xiaolong; Wang, Hu; Huang, Peng

doi:10.1016/j.gene.2018.09.005

Cited by 16 publications

(9 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The inconclusive roles of SNPs in specific cancer types suggest that pooled analysis is warranted. A meta-analysis containing 11,204 subjects reported that the rs699947 polymorphism within the VEGF (vascular endothelial growth factor) gene was associated with an increased risk of bladder cancer and renal cell carcinoma in Asians [4]. Another meta-analysis with 34,911 cases and 48,329 controls showed the genetic relationship between the BRCA2 (BRCA2 DNA repair associated) rs144848 polymorphism and the overall risk of cancer [5].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the effect of rs2295080 and rs2536 polymorphisms within the mTOR gene on cancer risk

Wang

Zhang

et al. 2020

Bioscience Reports

View full text Add to dashboard Cite

Abstract There is still no conclusion on the potential effect of the rs2295080 and rs2536 polymorphisms of mTOR (mammalian target of rapamycin) gene on different cancers. Herein, we performed a comprehensive assessment using pooled analysis, FPRP (false-positive report probability), TSA (trial sequential analysis), and eQTL (expression quantitative trait loci) analysis. Eighteen high-quality articles from China were enrolled. The pooled analysis of rs2295080 with 9502 cases and 10,965 controls showed a decreased risk of urinary system tumors and specific prostate cancers [TG vs. TT, TG+GG vs. TT and G vs. T; P<0.05, OR (odds ratio) <1]. FPRP and TSA data further confirmed these results. There was an increased risk of leukemia [G vs. T, GG vs. TT, and GG vs. TT+TG genotypes; P<0.05, OR>1]. The eQTL data showed a potential correlation between the rs2295080 and mTOR expression in whole blood samples. Nevertheless, FPRP and TSA data suggested that more evidence is required to confirm the potential role of rs2295080 in leukemia risk. The pooled analysis of rs2536 (6653 cases and 7025 controls) showed a significant association in the subgroup of “population-based” control source via the allele, heterozygote, dominant, and carrier comparisons (P<0.05, OR>1). In conclusion, the TG genotype of mTOR rs2295080 may be linked to reduced susceptibility to urinary system tumors or specific prostate cancers in Chinese patients. The currently data do not strongly support a role of rs2295080 in leukemia susceptibility. Large sample sizes are needed to confirm the potential role of rs2536 in more types of cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the effect of rs2295080 and rs2536 polymorphisms within the mTOR gene on cancer risk

Wang

Zhang

et al. 2020

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…In addition, VEGFA was modulated by apigenin (MOL009) and luteolin (MOL022). It has been reported in literature that VEGFA has many functions such as increasing vascular permeability, inducing angiogenesis, angiogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis [58][59][60]. us, these above analyses show that compound may treat NSCLC by regulating the angiogenesis, migration, and invasion.…”

Section: Invasion Modulementioning

confidence: 89%

Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula

Jiang

Liu

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Lung cancer is the most common cause of cancer death with high morbidity and mortality, which non-small-cell lung cancer (NSCLC) accounting for the majority. Traditional Chinese Medicine (TCM) is effective in the treatment of complex diseases, especially cancer. However, TCM is still in the conceptual stage. e interaction between different components remains unknown due to its multicomponent and multitarget characteristics. In this study, compound Liuju formula was taken as an example to isolate compounds with synergistic biological activity through systems pharmacology strategy. rough pharmacokinetic evaluation, 37 potentially active compounds were screened out. Meanwhile, 116 targets of these compounds were obtained by combing with the target prediction model. rough network analysis, we found that multicomponent drugs can present a synergistic effect through regulating inflammatory signaling pathway, invasion pathway, proliferation, and apoptosis pathway. Finally, it was confirmed that the bioactive compounds of compound Liuju formula have not only a killing effect on NSCLC tumor cells but also a synergistic effect on inhibiting the secretion of correlative inflammatory mediators, including TNF-α and IL-1β. e systems pharmacology method was applied in this study, which provides a new direction for analyzing the mechanism of TCM.

show abstract

“…E2F1 gene polymorphism is considered to be associated with lung cancer head and neck cancer and other cancers. VEGFA gene polymorphism has been confirmed to be associated with metastatic colorectal cancer bladder cancer, renal cell carcinoma, prostate cancer and other cancers (32)(33)(34)(35). FOXO 3a plays an inhibitory role in cancer and is closely related to malignant tumors such as breast cancer, colon cancer, prostate cancer, bladder cancer and nasopharyngeal carcinoma (36).…”

Section: Discussionmentioning

confidence: 99%

The key miRNAs for metastasis and survival of colon adenocarcinoma

Zhang

et al. 2019

Preprint

View full text Add to dashboard Cite

WGCNA (weighted gene co-expression network analysis) can provide a system-level insight into molecular interaction. To understand the co-expression pattern of miRNA in the progress of colon cancer development, this study constructed the WGCNA co-expression network to find the key microRNA of clinical significance and therefor provide possible personalized treatment targets. The miRNA expression data and clinical follow-up information of 442 valid colon cancer samples were obtained from TCGA. After the co-expression network was constructed, we found the turquoise module has the strongest correlation with stage IV. The miRNAs of the key module are enriched by GO and analyzed by KEGG, and the HUB-miRNAs are screened out through the network node degree. For clinical significance validation, data of 65 cases of colon cancer in GES29623 were analyzed by Cox regression and Kaplan-Meier, in 9 HUB-miRNAs, 2 miRNAs associated with overall survival rate were screened out.They can divide patients into high-risk group and low-risk group. Conclusion: has-miR-126-3p and has-miR-137 are the key miRNAs of COAD metastasis, they are of prognostic value in COAD.

show abstract

Association between vascular endothelial growth factor rs699947 polymorphism and the risk of three major urologic neoplasms (bladder cancer, prostate cancer, and renal cell carcinoma): A meta-analysis involving 11,204 subjects

Cited by 16 publications

References 50 publications

Comprehensive analysis of the effect of rs2295080 and rs2536 polymorphisms within the mTOR gene on cancer risk

Comprehensive analysis of the effect of rs2295080 and rs2536 polymorphisms within the mTOR gene on cancer risk

Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula

The key miRNAs for metastasis and survival of colon adenocarcinoma

Contact Info

Product

Resources

About