Association between Vascular Endothelial Growth Factor and Clinical Outcomes of IVF-ET/ICSI

Chen, Hui; Zheng, Jian-Bo; Wang, Dongmei; Hua, Xin; Wang, Hui

doi:10.29271/jcpsp.2019.01.19

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…However, oocyte morphological assessment may be performed only after oocyte denudation in ICSI cases and potential mechanisms that change the appearance of the oocyte are multifactorial (19). Age and the E 2 level on the HCG day are indirect indicators (20). Embryo quality reflects oocyte quality only retrospectively and neglects sperm-related factors (21).…”

Section: Discussionmentioning

confidence: 99%

Cystic fibrosis transmembrane conductance regulator in follicular fluid and cumulus cells and its relationship with age

Wang

Wei

et al. 2020

Exp Ther Med

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Oocyte quality deteriorates with female age and numerous indicators of oocyte quality exist. In the present study, the levels of cystic fibrosis transmembrane conductance regulator (CFTR) in the follicular fluid (FF) and cumulus cells (CCs) of infertile females in 3 different age groups were assessed to determine the relationship between CFTR and female age. The general features of the 3 groups, including age, body mass index, infertility duration, basal hormone levels and the number of retrieved oocytes were compared. The FF CFTR levels of the 3 groups were also compared and multiple age-related indicators of oocyte quality were analyzed, including the estradiol levels on the human chorionic gonadotropin injection day, the morphologically normal oocyte rate and the available or high-quality embryo rate. Immunofluorescence and PCR analyses were performed to examine CFTR expression in CCs around oocytes. The results indicated differences in general features and several indicators of oocyte quality among the 3 groups and significant differences in CFTR. The FF CFTR level was positively correlated with age, which was confirmed by immunofluorescence and PCR. Collectively, these results indicated that CFTR expression in FF and CCs may be associated with oocyte quality based on the age of individuals undergoing the assisted reproduction technique.

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Section: Discussionmentioning

confidence: 99%

Cystic fibrosis transmembrane conductance regulator in follicular fluid and cumulus cells and its relationship with age

Wang

Wei

et al. 2020

Exp Ther Med

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“…In light of the increasing evidence describing the connection between endothelial health and reproductive function, several endothelial markers have been evaluated as potential predictors of assisted reproductive technology (ART) outcome. For instance, among these, VEGF-A was identified as a negative predictor of in vitro fertilization (IVF) success, measured in both female blood [223] and embryo culture medium [224]. Moreover, several cytokines have been investigated in an ART setting.…”

Section: Endothelial Function and Assisted Reproductive Technologymentioning

confidence: 99%

“…Several VEGF SNPs were associated with recurrent spontaneous miscarriage, preeclampsia, and premature birth [231,232]. In addition, the frequency of C allele genotype in VEGF-A c.936C > T (rs7664413) and in c.405G > C (rs2010963) were higher in non-pregnant women after IVF than in those pregnant [224,233]. Similarly, the TNF c.-308A > G (rs1800629) A allele, associated to a reduced transcriptional activity [233], was linked to higher implantation and pregnancy rates in women undergoing ART [233,234].…”

Section: Endothelial Function and Assisted Reproductive Technologymentioning

confidence: 99%

The “Hitchhiker’s Guide to the Galaxy” of Endothelial Dysfunction Markers in Human Fertility

Santi

Spaggiari

Greco

et al. 2021

IJMS

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Endothelial dysfunction is an early event in the pathogenesis of atherosclerosis and represents the first step in the pathogenesis of cardiovascular diseases. The evaluation of endothelial health is fundamental in clinical practice and several direct and indirect markers have been suggested so far to identify any alterations in endothelial homeostasis. Alongside the known endothelial role on vascular health, several pieces of evidence have demonstrated that proper endothelial functioning plays a key role in human fertility and reproduction. Therefore, this state-of-the-art review updates the endothelial health markers discriminating between those available for clinical practice or for research purposes and their application in human fertility. Moreover, new molecules potentially helpful to clarify the link between endothelial and reproductive health are evaluated herein.

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Association of hTERT SNP (rs2736100) with implantation failure after in vitro fertilization and embryo transfer (IVF-ET)

Tajalli

Mashayekhi

Salehi

et al. 2020

British Journal of Biomedical Science

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Association between Vascular Endothelial Growth Factor and Clinical Outcomes of IVF-ET/ICSI

Cited by 5 publications

References 17 publications

Cystic fibrosis transmembrane conductance regulator in follicular fluid and cumulus cells and its relationship with age

Cystic fibrosis transmembrane conductance regulator in follicular fluid and cumulus cells and its relationship with age

The “Hitchhiker’s Guide to the Galaxy” of Endothelial Dysfunction Markers in Human Fertility

Association of hTERT SNP (rs2736100) with implantation failure after in vitro fertilization and embryo transfer (IVF-ET)

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