Association between variations in CAT and noise-induced hearing loss in two independent noise-exposed populations

Konings, Annelies; Laer, Lut Van; Pawełczyk, Małgorzata; Carlsson, Peder; Bondeson, Marie-Louise; Rajkowska, Elżbieta; Dudarewicz, Adam; Vandevelde, Ann; Fransén, Erik; Huyghe, Jeroen R.; Borg, Erik; Śliwińska-Kowalska, Mariola; Camp, Guy Van

doi:10.1093/hmg/ddm135

Cited by 85 publications

(67 citation statements)

References 50 publications

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“…[14,15] In noise-induced hearing loss and idiopathic sudden hearing loss, investigating the effect of oxidative stress included studying various enzyme polymorphisms, and some relationships between the gene polymorphisms and the diseases were found. [16,17] In this study of CAT gene promoter region A/T polymorphism genotypes, we did not find a statistically significant difference between those with sensorineural hearing loss and a normal control group.…”

Section: Discussioncontrasting

confidence: 55%

Glutathione peroxidase and catalase enzyme gene polymorphisms in profound congenital hearing loss

Tunç¹,

Baysal²,

Balcı³

et al. 2017

ENT Updates

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Section: Discussioncontrasting

confidence: 55%

Glutathione peroxidase and catalase enzyme gene polymorphisms in profound congenital hearing loss

Tunç¹,

Baysal²,

Balcı³

et al. 2017

ENT Updates

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“…In former genetic studies on these noise-exposed workers, resistant and sensitive subjects were selected using a Z-score based on the ISO 1999 (ISO 1999 -International Organization for Standardization, 1990) 36 leading to a selection of 347 sensitive and 338 resistant subjects. 20 Age and noise exposure level in this initial selection were not equally distributed between resistant and sensitive workers. This resulted in significant effects of the interaction between age and noise exposure level and their quadratic effects.…”

Section: Subjectsmentioning

confidence: 87%

“…This renders HSP70 the second gene whose association with NIHL has been replicated in independent populations, besides CAT. 20 Replication in independent sample sets is crucial to confirm susceptibility genes for complex diseases. Our results indicate that HSP70 genes may be valid NIHL susceptibility genes as significant associations were observed in three independent populations.…”

Section: Discussionmentioning

confidence: 99%

“…14 -17 In humans, association studies have identified KCNE1, 18 GSTM1 19 and CAT 20 as putative NIHL susceptibility genes. However, hitherto a specific causative variant was either not yet identified (CAT) 20 or has not yet been replicated in an independent population (KCNE1 and GSTM1). 18,21 Heat-shock proteins (HSPs) are a group of conserved proteins expressed ubiquitously in cells under both physiological and pathological circumstances.…”

Section: Introductionmentioning

confidence: 99%

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Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations

et al. 2008

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Noise-induced hearing loss (NIHL) is one of the most important occupational health hazards. Millions of people worldwide are exposed daily to harmful levels of noise. NIHL is a complex disease resulting from an interaction between genetic and environmental factors. Although the environmental risk factors have been studied extensively, little is known about the genetic factors. Heat-shock proteins (HSPs) are induced after exposure to severe noise. When first induced by exposure to moderate sound levels, they can protect the ear from damage from excessive noise exposure. This protection is highly variable between individuals. An association of HSP70 genes with NIHL has been described by Yang et al (2006) in a Chinese sample set of noise-exposed workers. In this study, three polymorphisms (rs1043618, rs1061581 and rs2227956) in HSP70-1, HSP70-2 and HSP70-hom, respectively, were genotyped in 206 Swedish and 238 Polish DNA samples of noise-exposed subjects and analyzed. One SNP, rs2227956 in HSP70-hom, resulted in a significant association with NIHL in both sample sets. In addition, rs1043618 and rs1061581 were significant in the Swedish sample set. Analysis of the haplotypes composed of the three SNPs revealed significant associations between NIHL and haplotype GAC in both sample sets and with haplotype CGT in the Swedish sample set. In conclusion, this study replicated the association of HSP70 genes with NIHL in a second and third independent noise-exposed sample set, hereby adding to the evidence that HSP70 genes may be NIHL susceptibility genes.

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“…However, firm evidence for the involvement of genetic factors in human NIHL was limited. Konings et al found significant associations between CAT gene single nucleotide polymorphisms (SNPs) and susceptibility to NIHL (14). In Shen's experiment, individuals with GSTM1 null genotype had a statistically significantly increased risk of NIHL (OR =1.64) compared with those who carrying a wild-type GSTM1 genotype (15).…”

Section: Introductionmentioning

confidence: 99%

PON2 and ATP2B2 gene polymorphisms with noise-induced hearing loss

Jun²,

Wang

et al. 2016

J. Thorac. Dis.

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Background: Noise-induced hearing loss (NIHL) is a complex disease induced by a combination of genetic and environmental factors. Paraoxonase2 (PON2) gene involved in the regulation of reactive oxygen species, and affecting the vulnerability of cochlea to NIHL, and ATPase, calcium-transporting, plasma membrane 2 (ATP2B2) gene which encodes plasma membrane calcium-transporting ATPase isoform 2 (PMCA2) are the candidate genes relating to the attack of NIHL. In this study, we investigated whether ATP2B2 and PON2 polymorphisms were associated with NIHL in Chinese of Han nationality population. Methods: We performed a case-control study between six single nucleotide polymorphisms (SNPs) (rs1719571, rs3209637 and rs4327369 within ATP2B2, rs12026, rs7785846 and rs12704796 within PON2) and NIHL in 454 subjects. All the SNPs were genotypes, using the TaqMan MGB probe assay. Odds ratios (ORs) were calculated with 95% confidence intervals (95% CIs) with logistic regression analysis to test the level of association for SNPs. Results: In our study, 221 subjects with hearing loss and 233 subjects without hearing loss were recruited.The frequencies of the CG and CG + GG genotype of rs12026 (PON2) conferred risk factors for NIHL with adjusted OR values of 2.62 (95% CI, 1.69-4.06) and 2.48 (95% CI, 1.63-3.78), respectively. This kind of significance was also found at locus rs7785846, where genotypes CT and CT + TT were the risk types, with adjusted ORs of 2.52 (95% CI, 1.62-3.93) and 2.35 (95% CI, 1.54-3.58), respectively. We performed stratified analysis per noise exposure level, when it came to rs7785846 and rs12026 in the >92 dB(A) noise exposure group, the subjects who carried heterozygote were of significantly (P<0.01) higher susceptibility to NIHL than homozygote carriers. By contrast, no significantly higher risk was found for any rs12704796 genotypes or any genotypes in ATP2B2 (P>0.05), which may suggest that these SNPs did not have significant effects on noise susceptibility across noise exposure. Conclusions: Our research suggested that PON2 might play a role in the etiology of NIHL in Chinese of Han nationality population.

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Association between variations in CAT and noise-induced hearing loss in two independent noise-exposed populations

Cited by 85 publications

References 50 publications

Glutathione peroxidase and catalase enzyme gene polymorphisms in profound congenital hearing loss

Glutathione peroxidase and catalase enzyme gene polymorphisms in profound congenital hearing loss

Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations

PON2 and ATP2B2 gene polymorphisms with noise-induced hearing loss

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