Association between Variants on Chromosome 4q25, 16q22 and 1q21 and Atrial Fibrillation in the Polish Population

Abstract

BackgroundGenome-wide studies have shown that polymorphisms on chromosome 4q25, 16q22 and 1q21 correlate with atrial fibrillation (AF). However, the distribution of these polymorphisms differs significantly among populations.ObjectiveTo test the polymorphisms on chromosome 4q25, 16q22 and 1q21 in a group of patients (pts) that underwent catheter ablation of AF.MethodsFour hundred and ten patients with AF that underwent pulmonary vein isolation were included in the study. Control group (n = 550) was taken from healthy population, matched for age, sex and presence of hypertension. All participants were genotyped for the presence of the rs2200733, rs10033464, rs17570669, rs3853445, rs6838973 (4q25), rs7193343 (16q22) and rs13376333 (1q21) polymorphisms.ResultsAll the polymorphisms tested (except rs17570669) correlated significantly with AF in univariate analysis (p values between 0.039 for rs7193343 and 2.7e-27 for rs2200733), with the odds ratio (OR) 0.572 and 0.617 for rs3853445 and rs6838973, respectively (protective role) and OR 1.268 to 3.52 for the other polymorphisms. All 4q25 SNPs tested but rs3853445 were independently linked with AF in multivariate logistic regression analysis. In haplotype analysis six out of nine 4q25 haplotypes were significantly linked with AF. The T allele of rs2200733 favoured increased number of episodes of AF per month (p = 0.045) and larger pulmonary vein diameter (recessive model, p = 0.032).ConclusionsPatients qualified for catheter ablation of AF have a significantly higher frequency of 4q25, 16q22 and 1q21 variants than the control group. The T allele of rs2200733 favours larger pulmonary veins and increased number of episodes of AF.

CYP11B2 T-344C Gene Polymorphism and Atrial Fibrillation: A Meta-Analysis of 2,758 Subjects

“…Single-nucleotide polymorphisms (SNPs) are DNA sequence polymorphisms caused by single nucleotide variations in the chromosomes, in which at least one allele frequency in the population is not less than 1%. SNPs are the most common human heritable variations [7].…”

KCNN3 SNP rs13376333 on Chromosome 1q21 Confers Increased Risk of Atrial Fibrillation

“…Over the last decade, a number of case-control studies have been conducted to investigate the association of SNP (single-nucleotide polymorphism) rs13376333 or KCNN3 with AF. [10][11][12][13] In addition, two additional European cohorts were able to replicate the results. 7) In contrast, another two case-control studies failed to replicate this association in a Chinese population.…”

FIRST RUSSIA-BASED STUDY OF POLYMORPHISM rs2200733 CHROMOSOME 4q25 ASSOCIATION WITH DEVELOPMENT OF THE LONE ATRIAL FIBRILLATION

“…Таким образом, наши данные, полученные впер-вые на Российской популяции, подтверждают полу-ченные ранее результаты целого ряда авторов [2,[8][9][10][11][12][13][14][15][16][17][18][19], указывающих на то, что генотип ТТ и аллель Т полиморфизма rs2200733 хромосомы 4q25 могут слу-жить предиктором возникновения ФП.…”

“…В последние годы особое внимание исследователей обращено на ассоциацию ФП с одно-нуклеотидным полиморфизмом (ОНП) rs2200733 в хромосоме 4q25. Исследование полиморфизма rs2200733 хромосомы 4q25 проведено на больших группах пациентов Европейской [8][9][10][11][12][13][14][15][16][17] и Азиатской [18,19] популяций. Однако данные о российских исследованиях выше описанного ОНП у больных с ФП в настоящее время отсутствуют.…”