Association between urticaria and virus infections: A systematic review

Abstract

Data obtained indicated viral infection as a potential trigger and sometimes as the main etiologic agent in causing acute or chronic urticaria. In every case, urticarial manifestation cleared up after either healing or controlling of the viral infection. However, prospective studies and well-structured research is needed to better clarify the role of viruses in the pathogenesis of urticaria and their relative prevalence.

Urticaria in children and adolescents: An updated review of the pathogenesis and management

“…The link of chronic urticaria to herpes virus infection is less evident. There are case reports, describing the disappearance of urticaria lesions after antiviral therapy in adult patients . Recent data also suggest that HHV‐6 and other human herpesviruses could play a role as cofactors in chronic urticaria .…”

Prevalence and Causes of Childhood Urticaria

“…Acute urticaria is more prevalent than chronic urticaria; however, chronic urticaria has a more significant impact on quality of life due to recurrence and unknown etiology 1. As in adults, the causes are different between acute and chronic urticaria in children,2345678 and it is difficult to determine the exact prevalence of childhood urticaria due to lack of papulation-based studies.…”

“…Infection is the most frequently documented cause (more than 40%) in children with acute urticaria 123. In a recent systematic review, viral infection was a potential trigger and sometimes the main cause in acute and chronic urticaria 4. The rate of identification of a specific cause in children with chronic urticaria varies from 20%-50%, but in practice, most patients have no precise causes and are classified as chronic idiopathic urticaria.…”

Features of the complement system in children with chronic urticaria

“…Исследование концентраций таких компонентов, как С3а, С4 и С1 ингибитор (С1inh), необходимо для выявления патологии си-стемы комплемента при ангиоотеках, уртикарном васкулите и других аутоиммунных заболеваниях, иммунодефицитных состояниях и рецидивирующих бактериальных инфекциях [7,8]. В связи с гетеро-генным характером хронической крапивницы и воз-можным наличием генетически детерменированных поломок в системе комплемента, влекущих за собой рецидивирование уртикарных высыпаний, ангиоо-теков, показано определение концентрации С3а, С4 и C1inh в сыворотке крови пациентов с хронической крапивницей.…”