Association between urinary tin concentration and diabetes in nationally representative sample of US adults

Liu, Buyun; Sun, Yangbo; Lehmler, Hans‐Joachim; Bao, Wei

doi:10.1111/1753-0407.12798

Cited by 16 publications

(3 citation statements)

References 25 publications

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“…A single longitudinal Finnish cohort study revealed a linear association between placental TBT levels and infant weight gain, although TBT was undetectable in the blood [388]. Although the National Health and Nutrition Examination Survey (NHANES) data are cross-sectional and, therefore, unsuitable for inferring causality, a recent analysis of NHANES data identified a significant link between elevated urinary total tin levels and diabetes [389]. In this population, exposure to tin was ubiquitous [390].…”

Section: Human Studiesmentioning

confidence: 86%

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel¹,

Howard²,

Agay-Shay³

et al. 2022

Biochemical Pharmacology

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Section: Human Studiesmentioning

confidence: 86%

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel¹,

Howard²,

Agay-Shay³

et al. 2022

Biochemical Pharmacology

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“…One recent study in the US general population found that urinary tin was positively associated with diabetes prevalence. 37 Experimental research suggested the potential role of tin in glucose tolerance and insulin resistance through induction of hepatic inflammation and excess hepatic fat accumulation. 38 In pancreatic β cells, tin was demonstrated to interfere with glucose-induced insulin secretion, due to its inhibitory effect on the cellular calcium response in triggering exocytosis of insulin granules.…”

Section: Discussionmentioning

confidence: 99%

Urinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN)

Wang

Karvonen‐Gutierrez

Herman

et al. 2020

BMJ Open Diab Res Care

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IntroductionEnvironmental exposure to metals may play a role in the pathogenesis of diabetes; however, evidence from human studies is limited. We prospectively evaluated the associations of 20 urinary metal concentrations and their mixtures with incident diabetes in the Study of Women’s Health Across the Nation, a multisite, multiethnic cohort study of midlife women.Research design and methodsThe sample included 1237 white, black, Chinese and Japanese-American women, aged 45–56 years, free of diabetes at baseline (1999–2000) who were followed through 2016. Concentrations of 20 metals (arsenic, barium, beryllium, cadmium, cobalt, chromium, cesium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, tin, thallium, uranium, vanadium, tungsten and zinc) were measured in urine specimens at baseline. Incident diabetes was identified annually by fasting glucose ≥126 mg/dL, self-reported doctor-diagnosed diabetes, or self-reported use of antidiabetic medications. A non-parametric clustering method, k-means clustering, was used to identify subgroups with different exposure patterns to metal mixtures.ResultsAfter multivariable adjustment, the HR (95% CI) for diabetes associated with each doubling increase in urinary metal concentrations was 1.19 (1.10 to 1.30) for arsenic and 1.20 (1.05 to 1.37) for lead, in Cox proportional hazards models after controlling for multiple comparisons. A doubling in urinary excretion of zinc was associated with higher risk of diabetes (adjusted HR 1.31, 95% CI 1.11 to 1.53). Two distinct exposure patterns to metal mixtures—‘high’ versus ‘low’—were identified. Participants assigned to the ‘high’ pattern had higher overall concentrations of all metals compared with those classified into the ‘low’ pattern. Adjusted HR for diabetes associated with ‘high’ pattern compared with ‘low’ was 1.42 (1.08 to 1.87).ConclusionsHigher urinary concentrations of arsenic and lead, increased urinary excretion of zinc, as well as higher overall exposure to metal mixtures were associated with elevated risk of diabetes. Future studies should further investigate the underlying mechanisms.

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“…This study also found that early life Sn exposure was related to long-term changes in glucose metabolism in children with ASD without a history of NDR. Higher Sn concentrations have been associated with diabetes in adults 67 .…”

Section: Lead and Tin Two Metals Associated With Changes In Glucose mentioning

confidence: 99%

Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder

et al. 2020

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Neurodevelopmental regression (NDR) is a subtype of autism spectrum disorder (ASD) that manifests as loss of previously acquired developmental milestones. Early life dysregulation of nutritional metals and/or exposure to toxic metals have been associated with ASD, but the underlying biological mechanisms by which metals influence neurodevelopment remain unclear. We hypothesize that metals influences neurodevelopment through dysregulation of bioenergetics. Prenatal and early postnatal metal exposures were measured using validated tooth-matrix biomarkers in 27 ASD cases (13 with NDR) and 7 typically-developing (TD) controls. Mitochondrial respiration and glycolysis were measured in peripheral blood mononuclear cells using the Seahorse XF96. Children with ASD demonstrated lower prenatal and postnatal Copper (Cu) and prenatal Nickel concentrations and Copper-to-Zinc (Cu/Zn) ratio as compared with TD children. Children with ASD and NDR showed greater metal-related disruption of cellular bioenergetics than children with ASD without NDR. For children with ASD and NDR mitochondrial respiration decreased as prenatal Manganese concentration increased and increased as prenatal Zinc concentration increased; glycolysis decreased with increased exposure to prenatal Manganese and Lead and postnatal Manganese. For children with ASD without a history of NDR, glycolysis increased with increased postnatal exposure to Tin. Language and communication scores in children with ASD were positively related to prenatal Cu exposure and Cu/Zn ratio. This study suggests that prenatal nutritional metals may be important for neurodevelopment in children with ASD, and that exposure to toxic metals and differences in nutritional metal exposures is associated with dysregulation of cellular bioenergetics, particularly in the NDR subtype of ASD.

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Association between urinary tin concentration and diabetes in nationally representative sample of US adults

Abstract: Environmental tin exposure was positively and significantly associated with diabetes in US adults.

Cited by 16 publications

References 25 publications

Obesity II: Establishing causal links between chemical exposures and obesity

Obesity II: Establishing causal links between chemical exposures and obesity

Urinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN)

Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder

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