Association between urinary metals and leukocyte telomere length involving an artificial neural network prediction: Findings based on NHANES 1999–2002

Xia, Fang; Li, Qingwen; Luo, Xin; Wu, Jinyi

doi:10.3389/fpubh.2022.963138

Cited by 18 publications

(17 citation statements)

References 29 publications

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“…Almost all cells in human body can synthesize TGF-β 1, which has the functions of immune regulation, promoting cell growth and differentiation, angiogenesis, immune regulation and so on ( Desai et al, 2018 ). Some studies ( Narod et al, 2015 ; Zheng et al, 2020 ; Chandra Jena et al, 2021 ; Xia et al, 2022 ) have found that under normal physiological conditions, TGF- β 1 inhibits the growth of tumor cells, and this inhibition still exists in the early stage of tumor, but once tumor cells enter the uncontrollable growth stage, the inhibition of TGF- β 1 will turn into promoting effect, leading to tumor occurrence and development. At present, related studies ( Zhang et al, 2014 , 7; Labrèche et al, 2021 ) have corroborated that BC-associated fibroblasts (CAFs) and epithelial-mesenchymal transformation (EMT) are the key links of tumor cell proliferation and metastasis.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Relationship between serum TGF- β 1, MMP-9 and IL-1β and pathological features and prognosis in breast cancer

et al. 2023

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To investigate the levels of serum transforming growth factor-β 1 (TGF-β1), Matrix metalloproteinase-9 (MMP-9) and Interleukin-1 β (IL-1 β) in breast cancer (BC), and analyzing their relationship with pathological features and prognosis. Retrospective analysis of 86 subjects with BC (BC subgroup) and another 50 healthy subjects (control subgroup) during the same period were included. The clinical data were collected. In this research, in BC subgroup, The levels of serum TGF- β 1, MMP-9 and IL-1 β were significantly higher than those in control subgroup. The levels of TGF- β 1 and MMP-9 in serum of BC subjects was correlated with clinical stage, histological grade, lymph node metastasis and molecular classification, but not with age, tumor size and menopausal status. The level of serum IL-1 β was related to tumor size, clinical stage, histological grade and lymph node metastasis. Multivariate Logistic regression analysis showed that the high level of serum TGF- β1 and MMP-9 was independent risk factors for BC. High level of serum IL-1 β was not an independent risk factor for BC. The 3-year disease-free survival rate in high TGF- β1 subgroup and high MMP-9 subgroup was significantly lower than that in low TGF- β 1 subgroup and low MMP- 9 subgroup. To conclude, serum TGF- β 1, MMP-9 and IL-1β are highly expressed in BC, and the subjects with elevated serum levels of TGF- β 1 and MMP-9 suggests poor prognosis.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Relationship between serum TGF- β 1, MMP-9 and IL-1β and pathological features and prognosis in breast cancer

et al. 2023

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“…At present, there is no definite conclusion on the correlation between the LTI angle and the patellar cartilage injury. Stefanik and other researchers have asserted that the LTI angle is significantly related to the patellar cartilage injury, but this is just opposite to the conclusion of previous reports (29)(30)(31)(32)(33)(34). In this study, the LTI angle of the control group was significantly greater than that of the CP group, which was consistent with Stefanik's conclusion.…”

Section: Discussioncontrasting

confidence: 59%

A study on the correlation between patellofemoral joint morphology and early patella malacia in young adults: quantitative analysis based on magnetic resonance

Kong¹,

Yu²

2023

Ann Transl Med

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Background The aim of this study was to quantitatively measure the morphology of the patellofemoral joint by magnetic resonance imaging (MRI) in young adults, to investigate the relationship between the morphology of the patellofemoral joint and chondromalacia patellae (CP), and to provide an imaging reference for early clinical diagnosis of CP. Methods A total of 57 cases of CP and 138 cases of normal knees were retrospectively collected and assigned to the CP group and control group, respectively. The morphological parameters of the patellofemoral joint were measured systematically. The statistical software SPSS 22.0 was used in correlation analysis. Logistic regression was used for univariate analysis. A P value <0.05 was defined as statistically significant. Results Wiberg index, patellar depth, and the lateral angle of the patella in the CP group were significantly lower than those in the control group (P=0.043, 0.001, 0.040, respectively). The width of the medial side of the trochlea, the ratio of the internal and external articular surfaces of the trochlea, the depth of the trochlea, and the inclination angle of the lateral trochlea in the CP group were significantly lower than those in the control group (P=0.003, 0.020, 0.000, 0.040, respectively), whereas the angle of the trochlea in the CP group was significantly higher than that in the control group (P=0.010). The lateral patellofemoral angle (LPA) and lateral patellofemoral contact width in the CP group were significantly lower than those in the control group (P=0.010, 0.010, respectively). In the CP group, with gender as a covariate, there were significant statistical differences between male and female in patellar depth, lateral patellar inclination angle, lateral trochlear inclination (LTI) angle, and lateral patellar contact surface width (P<0.05), whereas in the control group, there were significant differences in Wiberg index, patellar depth, medial trochlear width, and lateral patellofemoral contact surface width between male and female gender (P<0.05). Conclusions The prevalence of CP in women was significantly higher than that in men and the reduction of trochlea width and the patella depth is an important factor for the incidence of female CP. Morphological characteristics of the patellofemoral joint are significantly correlated with the occurrence of CP in young adults.

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“…Data was derived from the six continuous NHANES cycles from 2007-2008 to 2017-2018, which is a nationally representative population-based survey for assessing adult and child health and nutritional status in the United States [ 21 ]. The examination components consisted of medical, dental, and physiological measurements, and laboratory tests, which were supervised by trained medical personnel.…”

Section: Methodsmentioning

confidence: 99%

The Associations of Weekend Warrior Activity Patterns With the Visceral Adiposity Index in US Adults: Repeated Cross-sectional Study

Wang¹,

Xia²,

Li³

et al. 2023

JMIR Public Health Surveill

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Background According to previous reports, obesity especially visceral fat has become an important public health problem, causing an estimation of 20.5 disability-adjusted life years per 1000 inhabitants. Those who exercised for 1 or 2 days per week and reached the recommended 150 minutes of moderate physical activity (PA) per week have been defined as “weekend warriors” (WWs). Although the benefits of PA in suppressing obesity have been widely studied, the association of WWs with the Visceral Adiposity Index (VAI) and the difference between WW activity and regular PA are yet to be explored. Objective This study aims to explore the association between WW activity and other PA patterns with VAI in US adults. Methods The National Health and Nutrition Examination Survey 2007-2016 data set was used, and the analytic sample was limited to adults 20 years and older who had complete information about VAI, PA patterns, and other covariates, including demographic characteristics, behavioral factors, and disease conditions. Participants’ characteristics in different PA pattern groups were tested using the Rao and Scott adjusted χ2 test and ANOVA. Univariate and multivariate stepped linear regression models were then used to explore the association between the PA pattern and VAI. Finally, stratified analyses and interaction effects were conducted to investigate whether the association was stable among subgroups. Results The final sample included 9642 adults 20 years or older, which is representative of 158.1 million noninstitutionalized US adults, with 52.15% (n=5169) being male and 70.8% (n=4443) being non-Hispanic White. Gender, age group, race, education level, income level, marital status, smoking status, alcoholism, VAI, cardiovascular disease, and diabetes were all correlated with the PA pattern, but no relationship between hypertension and PA pattern was observed. After adjusting for demographic covariates, smoking status, alcoholism, cardiovascular disease, diabetes, and hypertension, WW and regularly active adults had a β of .307 (95% CI –0.611 to –0.003) and .354 (95% CI –0.467 to –0.241), respectively, for reduced VAI when compared with inactive adults, but no significant effect of lowering VAI (β=–.132, 95% CI –0.282 to 0.018) was observed in insufficiently active adults when compared with inactive adults. Besides, no significant difference was exhibited between WW adults and regularly active adults (β=.047, 95% CI –0.258 to 0.352), suggesting WW adults had the same benefit of decreasing VAI as regularly active adults. Stratified analyses results exhibited that WW activity was related to reduced VAI in female adults aged 20-44 years who were non-Hispanic Black, other, or multiracial; high school or General Educational Development education; and never married, and the association between PA pattern and VAI remained stable in all demographic subgroups. Conclusions Compared with inactive adults, WWs could reduce VAI, and there was no significant difference between WWs and regular active adults in decreasing VAI. Our study provides compelling evidence of the beneficial effect of WW activity on visceral obesity.

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Association between urinary metals and leukocyte telomere length involving an artificial neural network prediction: Findings based on NHANES 1999–2002

Cited by 18 publications

References 29 publications

RETRACTED: Relationship between serum TGF- β 1, MMP-9 and IL-1β and pathological features and prognosis in breast cancer

RETRACTED: Relationship between serum TGF- β 1, MMP-9 and IL-1β and pathological features and prognosis in breast cancer

A study on the correlation between patellofemoral joint morphology and early patella malacia in young adults: quantitative analysis based on magnetic resonance

The Associations of Weekend Warrior Activity Patterns With the Visceral Adiposity Index in US Adults: Repeated Cross-sectional Study

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