Association between urinary bisphenol A concentrations and semen quality: A meta-analytic study

Castellini, Chiara; Medvedec, Mario; Parisi, Antonio; Totaro, Maria; Tienforti, Daniele; Cordeschi, Giuliana; Baroni, Marco Giorgio; Maccarrone, Mauro; Necozione, Stefano; Francavilla, Sandro; Barbonetti, Arcangelo

doi:10.1016/j.bcp.2021.114896

Cited by 11 publications

(4 citation statements)

References 48 publications

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“…Although much of the data seem compelling, more is still needed to make confident conclusions. A meta-analysis examined the relationship between urinary BPA concentrations and semen quality and found a ‘clinically negligible’ association between the two after pooling data from 9 studies [22]. A review by Hart [23] states that prenatal BPA exposure may have negative impacts on male fertility, but more data are required to clarify findings.…”

Section: Endocrine-disrupting Chemicals and Other Toxins In Water And...mentioning

confidence: 99%

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

Seli

Taylor

2023

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewRapid increase in world population accompanied by global industrialization has led to an increase in deployment of natural resources, resulting in growing levels of pollution. Here, we review recent literature on the impact of environmental pollution on human reproductive health and assisted reproduction outcomes, focusing on two of the most common: air pollution and endocrine disruptors. Recent findingsAir pollution has been associated with diminished ovarian reserve, uterine leiomyoma, decreased sperm concentration and motility. Air pollution also correlates with decreased pregnancy rates in patients undergoing infertility treatment using in-vitro fertilization (IVF). Similarly, Bisphenol A (BPA), a well studied endocrine disrupting chemical, with oestrogen-like activity, is associated with diminished ovarian reserve, and abnormal semen parameters, while clinical implications for patients undergoing infertility treatment remain to be established. SummaryThere is convincing evidence that environmental pollutants may have a negative impact on human health and reproductive potential. Air pollutions and endocrine disrupting chemicals found in water and food seem to affect male and female reproductive function. Large-scale studies are needed to determine the threshold values for health impact that may drive targeted policies.

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Section: Endocrine-disrupting Chemicals and Other Toxins In Water And...mentioning

confidence: 99%

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

Seli

Taylor

2023

Current Opinion in Obstetrics &Amp; Gynecology

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“…91,115 However, a recent meta-analysis found that urinary BPA levels show a significant association solely with sperm motility. 116 Moreover, this association lost its significance following adjustments for publication bias or in a sensitivity analysis. 116 A more recent meta-analysis revealed no significant association between urinary BPA levels and semen quality parameters, including sperm concentration, count, morphology, motility, or semen volume.…”

Section: Nonpersistent Chemicalsmentioning

confidence: 99%

“…116 Moreover, this association lost its significance following adjustments for publication bias or in a sensitivity analysis. 116 A more recent meta-analysis revealed no significant association between urinary BPA levels and semen quality parameters, including sperm concentration, count, morphology, motility, or semen volume. 117 Despite this, a recent systematic review presented robust evidence linking BPA exposure to diminished semen quality.…”

Section: Nonpersistent Chemicalsmentioning

confidence: 99%

Deteriorating Semen Quality: The Role of the Environment

Virtanen,

Rodprasert,

Toppari

2023

Semin Reprod Med

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Since the end of the last century, several reports have suggested that semen quality is declining, especially in Western countries. Furthermore, cross-sectional studies using similar protocols have suggested regional differences in semen quality of young and fertile men. Reasons for these regional differences and local adverse trends in semen quality are unknown, but environmental factors are suspected to have a role. Besides adulthood environmental exposures, those occurring during testicular development may also affect semen quality. Longitudinal follow-up studies and mixture risk analyses are needed to study the effect of fetal, childhood, and adult life environment on semen quality.

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“…Kortenkamp carried out a systematic review of epidemiological studies and attributed the divergent findings on sperm quality to differences in exposure conditions [ 18 ]. Castellini meta-analyzed the correlation between BPA and semen quality [ 19 ]. However, findings of reproductive hormones from epidemiologic studies are not well discussed.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A Exposure Interferes with Reproductive Hormones and Decreases Sperm Counts: A Systematic Review and Meta-Analysis of Epidemiological Studies

Lü,

Liu,

Yang

et al. 2024

Toxics

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Bisphenol A (BPA), an acknowledged endocrine disrupter, is easily exposed to humans via food packaging and container. However, a consensus has not been reached on the extent to which BPA exposure affects the reproductive system. We therefore conducted this systematic review and meta-analysis to elucidate the relationship between BPA exposure and male reproduction-related indicators. Up to October 2023, a comprehensive search was carried out in the PubMed, Embase, Cochrane and Web of Science, and 18 studies were ultimately included. β coefficients from multivariate linear regression analyses were pooled using a random effects model. The results showed that the urinary BPA concentration was negatively correlated with the sperm concentration (β coefficient = −0.03; 95% CI: −0.06 to −0.01; I2 = 0.0%, p = 0.003) and total sperm count (β coefficient = −0.05; 95% CI: −0.08 to −0.02; I2 = 0.0%, p < 0.001). In addition, BPA concentrations were associated with increased sex hormone-binding globulin (SHBG) levels, increased estradiol (E2) levels, and reduced biologically active androgen levels. However, the relationship between an increased risk of below-reference sperm quality and BPA exposure was not robust. This systematic review revealed that BPA exposure disrupts reproductive hormones, reduces sperm counts and may ultimately adversely affect male reproduction.

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Association between urinary bisphenol A concentrations and semen quality: A meta-analytic study

Cited by 11 publications

References 48 publications

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

Deteriorating Semen Quality: The Role of the Environment

Bisphenol A Exposure Interferes with Reproductive Hormones and Decreases Sperm Counts: A Systematic Review and Meta-Analysis of Epidemiological Studies

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