Association between uric acid, cancer incidence and mortality in patients with type 2 diabetes: Shanghai diabetes registry study

Deng, Zihao; Gu, Yunjuan; Hou, Xuhong; Zhang, Lei; Bao, Yuqian; Hu, Cheng; Jia, Weiping

doi:10.1002/dmrr.2724

Cited by 20 publications

(13 citation statements)

References 31 publications

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“…Conversely, a cohort study of 83,683 participants in Austria found that high levels of serum uric acid were linked to a higher risk of all cancer mortality [9]. Furthermore, a cohort study of 8,274 participants in China found that incidence of cancer increased with serum uric acid levels, but only in females with diabetes [10]. A recent systematic review and meta-analysis of 17 studies on the link between serum uric acid and cancer incidence and mortality was inconclusive [2].…”

Section: Introductionmentioning

confidence: 99%

Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study

et al. 2017

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ObjectivesSerum uric acid has been suggested to be associated with cancer risk. We aimed to study the association between serum uric acid and cancer incidence in a large Swedish cohort.ResultsA positive association was found between uric acid levels and overall cancer risk, and results were similar with adjustment for glucose, triglycerides and BMI. Hazard ratio (HR) for overall cancer for the 4th quartile of uric acid compared to the 1st was 1.08 (95% CI: 1.05–1.11) in men and 1.12 (1.09 – 1.16) in women. Site-specific analysis showed a positive association between uric acid and risk of colorectal, hepatobiliary, kidney, non-melanoma skin, and other cancers in men and of head and neck and other cancers in women. An inverse association was observed for pulmonary and central nervous system (CNS) cancers in men and breast, lymphatic and haematological, and CNS malignancies in women.Materials and MethodsWe included 493,281 persons aged 20 years and older who had a measurement of serum uric acid and were cancer-free at baseline in the AMORIS study. Multivariable Cox proportional hazards regression was used to investigate sex-specific quartiles of serum uric acid in relation to cancer risk in men and women. Analysis was further adjusted for serum glucose, triglycerides and, where available, BMI. Site-specific analysis was performed for major cancers.ConclusionsAltered uric acid levels were associated with risk of overall and some specific cancers, further indicating the potential role of uric acid metabolism in carcinogenesis.

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Section: Introductionmentioning

confidence: 99%

Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study

et al. 2017

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“…A number of epidemiologic studies have shown that an elevated uric acid level is associated with a wide variety of adverse health outcomes, including hypertension, metabolic syndrome, kidney disease, cardiovascular disease (CVD), and cancer . However, the role of uric acid as an independent risk factor for CVD, cancer, and all‐cause mortality remains a subject of controversy . Some studies demonstrated a positive association between hyperuricemia and cardiovascular mortality , while other studies did not .…”

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confidence: 99%

U‐Shaped Association Between Serum Uric Acid Level and Risk of Mortality

Cho

Chang

Kim

et al. 2018

Arthritis & Rheumatology

124

122

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“…There have already been suggestions for prediction models to screen newly diagnosed diabetic patients for pancreatic cancer, which include individual characteristics such as age, body mass index, change in body mass index, smoking, use of proton pump inhibitors, and antidiabetic medications, as well as levels of haemoglobin A1C, cholesterol, haemoglobin, creatinine, and alkaline phosphatase . High levels of uric acid were also suggested as a potential marker in diabetic patients …”

Section: Discussionmentioning

confidence: 99%

Newly diagnosed type 2 diabetes may serve as a potential marker for pancreatic cancer

Dankner

Freedman

Gerstein

et al. 2018

Diabetes Metabolism Res

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Pancreatic cancer has an extremely highly case fatality. Diabetes is a well-established strong risk factor for pancreatic cancer. Compared with a nondiabetic population, we previously reported a 15- and 14-fold greater risk for detecting pancreatic cancer during the first year after diagnosing diabetes in adult women and men, respectively, which dropped during the second year to 5.4-fold and 3.5-fold, respectively, and stabilized around 3-fold for the rest of the 11-year follow-up in our historical cohort. The population attributable risk during the 11-year period was 13.3% and 14.1% in prevalent diabetic women and men, respectively. This means that one out of about every 8 patients diagnosed with pancreatic cancer has been previously diagnosed with diabetes. The globally high prevalence of diabetes and the aggravating implications of a delayed pancreatic cancer diagnosis call for newly-onset diabetes to be considered a potential marker for an underlying pancreatic cancer and addressed accordingly.

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Association between uric acid, cancer incidence and mortality in patients with type 2 diabetes: Shanghai diabetes registry study

Abstract: In Chinese female diabetic patients, the incidence of cancer increased with serum uric acid levels.

Cited by 20 publications

References 31 publications

Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study

Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study

U‐Shaped Association Between Serum Uric Acid Level and Risk of Mortality

Newly diagnosed type 2 diabetes may serve as a potential marker for pancreatic cancer

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