Association between uric acid and height during growth hormone therapy in children with idiopathic short stature

Yoon, Jong Seo; Seo, Young‐Joon; Kwon, Eun Byul; Lee, Hye Jin; Kang, Min Jae; Hwang, Il Tae

doi:10.3389/fendo.2022.1025005

Cited by 4 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study revealed a non-linear relationship between UA concentrations and IGF-1 SDS in children and adolescents with ISS, where IGF-1 SDS was positively correlated with appropriate serum UA concentrations, while too high or too low serum UA levels were associated with lower IGF-1 SDS values ( 11 ). Another longitudinal study of 182 prepubertal ISS children treated with rhGH for 30 months showed that UA was significantly associated with height SDS after controlling for sex, age, and BMI SDS, and no statistical correlation was observed despite similar trends in increasing IGF-1 SDS and UA levels ( 34 ). In boys with obesity and NAFLD, no change was observed in UA levels at months 3 and 6 of rhGH administration ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Uric acid levels correlate with disease activity in growth hormone-secreting pituitary adenoma patients

Mo,

Chen,

Wang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveFew studies reported the effects of growth hormone-secreting pituitary adenoma (GHPA) on uric acid (UA) metabolism and the relationship between growth hormone (GH)/insulin-like growth factor-1 (IGF-1) levels and UA are controversial. This study aimed to evaluate the relationship between IGF-1 and UA in patients with GHPA and to further clarify whether UA levels are associated with GHPA disease activity by follow-up.MethodsA longitudinal study of 424 GHPA patients presenting to Beijing Tiantan Hospital, Capital Medical University between January 2015 and January 2023 was conducted. Spearman’s correlation tests were performed to examine the relationship between IGF-1 and UA at baseline. Univariate and multivariate linear regression analysis was conducted to investigate the independent association between UA and IGF-1. Changes in postoperative IGF-1 and UA levels were followed prospectively, and the differences in UA levels between the biochemical remission and nonremission groups were compared.ResultsAt baseline, male patients, the lower the age, the higher the IGF-1 and body mass index (BMI), and the higher the UA levels. IGF-1 was significantly associated with UA after controlling for sex, age, and BMI (r = 0.122, P = 0.012). In adjusted multiple linear regression analysis, IGF-1 was independently associated with UA, and UA levels increased significantly with increasing IGF-1. During postoperative follow-up, UA decreased gradually as IGF-1 levels decreased. At 12 months postoperatively, UA levels were significantly lower in the biochemical remission group than in the nonremission group (P = 0.038).ConclusionsIn patients with GHPA, UA levels are associated with disease activity. Changes in UA levels should be taken into account in the comprehensive treatment of GHPA, patients presenting with HUA should be given lifestyle guidance and appropriate urate-lowering treatment according to their condition to better improve their prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Uric acid levels correlate with disease activity in growth hormone-secreting pituitary adenoma patients

Mo,

Chen,

Wang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…These criteria, as well as a consideration of the interpretability of group size and meaningfulness of differences in trajectories, were used to select the final trajectory model. In addition, we examined the average posterior probability and the odds of correct classification (based on the weighted posterior probability) to assess model performance [using thresholds of >.70 and ≥5.0, respectively (47, 48)].…”

Section: Developmental Changes In Salivary Uric Acid Concentrationsmentioning

confidence: 99%

Salivary uric acid across child development and associations with weight, height, and body mass index

Riis,

Dent,

Silke

et al. 2023

Front. Pediatr.

View full text Add to dashboard Cite

IntroductionObesity during childhood is a serious and growing chronic disease with consequences for lifelong health. In an effort to advance research into the preclinical indicators of pediatric obesity, we examined longitudinal assessments of uric acid concentrations in saliva among a cohort of healthy children from age 6-months to 12-years (n's per assessment range from 294 to 727).MethodsUsing data from a subsample of participants from the Family Life Project (an Environmental influences on Child Health Outcomes Program cohort), we: (1) characterized salivary uric acid (sUA) concentrations from infancy to early adolescence by sex and race; (2) assessed changes in sUA levels across development; and (3) evaluated associations between sUA concentrations and measures of child weight, height, and body mass index (BMI). Across four assessments conducted at 6-, 24-, 90-, and 154-months of age, 2,000 saliva samples were assayed for UA from 781 participants (217 participants had sUA data at all assessments).ResultsThere were no significant differences in sUA concentrations by sex at any assessment, and differences in sUA concentrations between White and non-White children varied by age. At the 90- and 154-month assessments, sUA concentrations were positively correlated with measures of child weight, height, and BMI (90-month: weight- ρ(610) = 0.13, p < 0.01; height- ρ(607) = 0.10, p < 0.05; BMI- ρ(604) = 0.13, p < 0.01; 154-month: weight- ρ(723) = 0.18, p < 0.0001; height- ρ(721) = 0.10, p < 0.01; BMI- ρ(721) = 0.17, p < 0.0001). Group based trajectory modeling identified two groups of children in our sample with distinct patterns of sUA developmental change. The majority (72%) of participants showed no significant changes in sUA across time (“Stable” group), while 28% showed increases in sUA across childhood with steep increases from the 90- to 154-month assessments (“Increasing” group). Children in the Increasing group exhibited higher sUA concentrations at all assessments (6-month: t(215) = −5.71, p < 0.001; 24-month: t(215) = −2.89, p < 0.01; 90-month: t(215) = −3.89, p < 0.001; 154-month: t(215) = −19.28, p < 0.001) and higher weight at the 24- and 90-month assessments (24-month: t(214) = −2.37, p < 0.05; 90-month: t(214) = −2.73, p < 0.01).DiscussionOur findings support the potential utility of sUA as a novel, minimally-invasive biomarker that may help advance understanding of the mechanisms underlying obesity as well as further surveillance and monitoring efforts for pediatric obesity on a large-scale.

show abstract

“…Furthermore, recent evidence suggests that height and IR are also negatively correlated 16 , suggesting that individuals with short stature have a significantly increased risk of developing CVD and IR. Additionally, a longitudinal study conducted in children with idiopathic short stature revealed a correlation between SUA levels and height standard deviation score (SDS) 17 . Furthermore, short stature in childhood is associated with health status in adulthood 18 .…”

Section: Introductionmentioning

confidence: 99%

Association between serum uric acid and triglyceride-glucose index in children and adolescents with short stature

Zhao,

Zhang,

Chu

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The aim of this study was to explore the relationship between serum uric acid (SUA) and the triglyceride-glucose (TyG) index, which is a more effective indicator of insulin resistance. The study participants included 1700 children and adolescents with short stature who were recruited at the Affiliated Hospital of Jining Medical University in China between March 2013 and April 2021. A positive association between SUA levels and the TyG index was detected by univariate analysis (p < 0.001). Furthermore, a nonlinear relationship was detected between SUA and the TyG index, whose point was 6.55 mg/dL. There was a positive association between SUA and the TyG index when the SUA level was greater than 6.55 mg/dL (β 0.17, 95% CI: 0.07, 0.27; P < 0.001). However, we did not observe a significant relationship between SUA and the TyG index when the SUA level was less than 6.55 mg/dL (β 0.02, 95% CI: − 0.01, 0.05; P = 0.091). In addition, a stratified analysis was performed to appraise changes in this relationship for different sexes. The relationship between SUA and the TyG index in males and females is consistent with that in the general population, showing a nonlinear relationship. However, the inflection points of SUA level were significantly higher in males than in females, and the inflection points were approximately 6.72 and 5.88 mg/dL, respectively. This study revealed a nonlinear relationship between SUA and the TyG index in children with short stature. The nonlinear relationship remained in gender stratification analysis, but the inflection point of SUA level was higher in men. Further studies are needed to establish a causal relationship between SUA levels and the TyG index in children with short stature.

show abstract

Association between uric acid and height during growth hormone therapy in children with idiopathic short stature

Cited by 4 publications

References 25 publications

Uric acid levels correlate with disease activity in growth hormone-secreting pituitary adenoma patients

Uric acid levels correlate with disease activity in growth hormone-secreting pituitary adenoma patients

Salivary uric acid across child development and associations with weight, height, and body mass index

Association between serum uric acid and triglyceride-glucose index in children and adolescents with short stature

Contact Info

Product

Resources

About