Association between Triglyceride-Rich-Lipoprotein subfractions and carotid atherosclerosis in post-menopausal women

Fata, Ersilia La; Gentile, Marco; Iannuzzi, A.; Covetti, Giuseppe; D’Elia, Lanfranco; Iannuzzo, Gabriella; Panico, Salvatore; Rubba, P.

doi:10.1016/j.numecd.2016.11.072

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“…Our histological data show that hypertriglyceridemia is a risk factor for carotid atherosclerosis especially in elderly women further confirming some observations based on other methodologies. La Fata et al [ 48 ] found that, in a sample of post-menopausal women aged > 60 years, high concentrations of triglyceride-rich-lipoproteins (TRLPs) are independently associated with the risk of carotid atherosclerosis, evaluated by intima-media thickness ultrasound measurement. Moreover, Ahmad et al [ 49 ] showed that adiposity might increase the genetic influences on hypertriglyceridemia among women and in particular these effects appear stronger for very-large-TRLPs subfraction.…”

Section: Discussionmentioning

confidence: 99%

The risk of carotid plaque instability in patients with metabolic syndrome is higher in women with hypertriglyceridemia

Servadei

Anemona

Cardellini

et al. 2021

Cardiovasc Diabetol

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Background Metabolic syndrome certainly favors growth of carotid plaque; however, it is uncertain if it determines plaque destabilization. Furthermore, it is likely that only some components of metabolic syndrome are associated with increased risk of plaque destabilization. Therefore, we evaluated the effect of different elements of metabolic syndrome, individually and in association, on carotid plaques destabilization. Methods A total of 186 carotid endarterectomies from symptomatic and asymptomatic patients were histologically analysed and correlated with major cardiovascular risk factors. Results Metabolic syndrome, regardless of the cluster of its components, is not associated with a significant increase in risk of plaque destabilization, rather with the presence of stable plaques. The incidence of unstable plaques in patients with metabolic syndrome is quite low (43.9 %), when compared with that seen in the presence of some risk factors, but significantly increases in the subgroup of female patients with hypertriglyceridemia, showing an odds ratio of 3.01 (95% CI, 0.25–36.30). Conclusions Our data may help to identify patients with real increased risk of acute cerebrovascular diseases thus supporting the hypothesis that the control of hypertriglyceridemia should be a key point on prevention of carotid atherosclerotic plaque destabilization, especially in post-menopausal female patients.

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Section: Discussionmentioning

confidence: 99%