Association between triglyceride/HDL cholesterol ratio and carotid atherosclerosis in postmenopausal middle-aged women

Masson, Walter; Siniawski, Daniel; Lobo, Martín; Molinero, Graciela; Huerín, Melina

doi:10.1016/j.endoen.2016.08.005

Cited by 21 publications

(19 citation statements)

References 28 publications

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“…TG/HDL cholesterol ratio is closely associated with atherosclerosis regardless of their stenosis degree. [8,17,29,30] It can result from small/dense LDL particles which are susceptible to oxidation, leading to atherogenesis. [12,26] VLDL, which coexists with atherogenic dyslipidemia, also accelerates atherosclerosis by being uptaken into macrophages and developing foam cells.…”

Section: Discussionmentioning

confidence: 99%

“…[26] Because advanced atherosclerosis can result in diffuse-hypoperfusion, extravasation of toxic metabolites into neural tissues, and occlusion of small arterioles,[22] high TG/HDL cholesterol may ratio be associated with the prevalence of SBI through higher atherosclerosis burden; second, inflammation and oxidative stress may play a role. TG/HDL cholesterol ratio indicates IR status, [17,18,29,31,32] and then, it also means increased subclinical inflammation, disturbed metabolic status, and elevated sympathetic tone. [31,33] This high inflammation burden promote downstream of lipid peroxidation and cellular/DNA damage, leading to endothelial dysfunction/arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

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High Triglyceride/HDL Cholesterol Ratio is Associated with Silent Brain Infarcts in a Healthy Population

Nam

Kwon

Jeong

et al. 2019

Preprint

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Background: Triglycerides (TG)/high-density lipoprotein (HDL) cholesterol ratio is a marker of small/dense low-density lipoprotein particles, which are closely associated with various metabolic and vascular diseases. However, the role of TG/HDL cholesterol ratio in cerebrovascular diseases has not been well studied. In this study, we evaluated the relationship between TG/HDL cholesterol ratio and the presence of silent brain infarct (SBI) in a neurologically healthy population. Methods: We retrospectively evaluated consecutive participants in health check-ups between January 2006 and December 2013. SBI was defined as an asymptomatic, well-defined lesion with a diameter of ≥ 3 mm on T1- or T2-weighted images. TG/HDL cholesterol ratio was calculated after dividing absolute TG levels by absolute HDL cholesterol levels. Results: Of 3,172 healthy participants, 263 (8.3%) had SBI lesions. In multivariate analysis, TG/HDL cholesterol ratio was independently associated with SBI (adjusted odds ratio [aOR] = 1.17, 95% confidence interval [CI] = 1.04 to 1.32, P = 0.012). This association was prominent in males (aOR = 1.20, 95% CI = 1.04 to 1.40, P = 0.015), but not in females. Other lipid parameters, such as HDL cholesterol (aOR = 0.87, 95% CI = 0.75 to 1.00, P = 0.042), TG (aOR = 1.15, 95% CI = 1.02 to 1.31, P = 0.02), and total cholesterol/TG ratio (aOR = 0.86, 95% CI = 0.75 to 1.00, P = 0.043) also showed significant relationships with SBI, when they were respectively adjusted for confounders. In the analyses of the relationships between lipid parameters and SBI lesion burden, TG/HDL cholesterol ratio was positively correlated, and total cholesterol/TG ratio was negatively correlated with SBI lesion burden, in dose-response manners (P for trend = 0.015 and 0.002, respectively). Conclusions: The TG/HDL cholesterol ratio was positively associated with the prevalence of SBI in a neurologically healthy population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High Triglyceride/HDL Cholesterol Ratio is Associated with Silent Brain Infarcts in a Healthy Population

Nam

Kwon

Jeong

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…TG/HDL cholesterol ratio is closely associated with atherosclerosis regardless of their stenosis degree. [8,17,29,30] It can result from small/dense LDL particles which are susceptible to oxidation, leading to atherogenesis. [12,26] VLDL, which coexists with atherogenic dyslipidemia, also accelerates atherosclerosis by being taken into macrophages and developing foam cells.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High Triglyceride/HDL Cholesterol Ratio is Associated with Silent Brain Infarcts in a Healthy Population

Nam

Kwon

Jeong

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Triglycerides (TG)/high-density lipoprotein (HDL) cholesterol ratio is a marker of small/dense low-density lipoprotein particles, which are closely associated with various metabolic and vascular diseases. However, the role of TG/HDL cholesterol ratio in cerebrovascular diseases has not been well studied. In this study, we evaluated the relationship between TG/HDL cholesterol ratio and the presence of silent brain infarct (SBI) in a neurologically healthy population. Methods: We retrospectively evaluated consecutive participants in health check-ups between January 2006 and December 2013. SBI was defined as an asymptomatic, well-defined lesion with a diameter of ≥ 3 mm on T1- or T2-weighted images. TG/HDL cholesterol ratio was calculated after dividing absolute TG levels by absolute HDL cholesterol levels. Results: Of 3,172 healthy participants, 263 (8.3%) had SBI lesions. In multivariate analysis, TG/HDL cholesterol ratio was independently associated with SBI (adjusted odds ratio [aOR] = 1.16, 95% confidence interval [CI] = 1.00 to 1.34, P = 0.047). This association was prominent in males (aOR = 1.23, 95% CI = 1.03 to 1.48, P = 0.021), but not in females. In the analyses of the relationships between lipid parameters and SBI lesion burden, TG/HDL cholesterol ratio was positively correlated, and total cholesterol/TG ratio was negatively correlated with SBI lesion burden, in dose-response manners (P for trend = 0.015 and 0.002, respectively). Conclusions: The TG/HDL cholesterol ratio was positively associated with the prevalence of SBI in a neurologically healthy population.

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“…Además, la resistencia a la insulina aporta gran cantidad de triglicéridos y mayor aclaramiento hepático del HDL-c (12) . La relación triglicéridos/HDL-c es un marcador subrogado de resistencia a la insulina y revela una gran probabilidad de placas ateroscleróticas en la carótida (13) .…”

Section: Fisiopatologíaunclassified

Síndrome metabólico en el climaterio

Peralta

2018

Rev peru ginecol obstet.

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El aumento de la expectativa de vida de las mujeres se ha traducido en incremento de la morbimortalidad en las mujeres mayores, siendo las enfermedades cardiovasculares una de las más prevalentes. Una de las principales causas de morbilidad es el síndrome metabólico. Es necesario orientar al médico y a sus pacientes sobre las consecuencias de esta patología. Son los varones quienes son más tratados, dejando de lado a las mujeres por la errada percepción de que tienen un riesgo cardiovascular bajo. La fisiopatología de la resistencia a la insulina abre un abanico de conocimientos relacionados al incremento de los triglicéridos en sangre y con el mayor aclaramiento del HDL-colesterol por parte del hígado. La obesidad abdominal y la hipertensión arterial completan los elementos de diagnóstico del síndrome metabólico, el cual se hace cuando existen tres de los cinco factores mencionados. Durante la transición menopáusica hay un rápido incremento en la severidad de este síndrome, lo que provoca un aumento del riesgo cardiovascular. En la obesidad hay un estado proinflamatorio inducido por la mayor producción de citoquinas inflamatorias como TNF-alfa, resistina, leptina, por el adipocito obeso, las cuales están vinculadas con la mayoría de las enfermedades crónicas y con el cáncer. En relación a la hipertensión arterial, hay muchas pacientes que desconocen que son portadoras de esta patología y no se hacen tratar, aumentando su riesgo cardiovascular. Por todo lo anterior, el médico ginecólogo debe de familiarizarse con esta patología y tener una actitud activa al respecto con relación a su diagnóstico y manejo.

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Association between triglyceride/HDL cholesterol ratio and carotid atherosclerosis in postmenopausal middle-aged women

Cited by 21 publications

References 28 publications

High Triglyceride/HDL Cholesterol Ratio is Associated with Silent Brain Infarcts in a Healthy Population

High Triglyceride/HDL Cholesterol Ratio is Associated with Silent Brain Infarcts in a Healthy Population

High Triglyceride/HDL Cholesterol Ratio is Associated with Silent Brain Infarcts in a Healthy Population

Síndrome metabólico en el climaterio

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