Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional study

Liu, Jiuling; Min, Yang Gi; Wang, Yuanwei

doi:10.1136/bmjopen-2022-069663

Cited by 7 publications

(1 citation statement)

References 38 publications

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“…The loss of muscle mass or strength and the development of chronic diseases, such as CVD and cognitive impairment, are the main contributors to frailty in older people. The TyG index has been reported to be positively related to sarcopenia, in populations with hypertension or without DM, as well as in adolescents or older people [21,[41][42][43]. Moreover, an elevated TyG index has been suggested to lead to elevated risk of CVD and mortality in cross-sectional or prospective studies [44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Association of the triglyceride-glucose index and its related parameters with frailty

Yin,

Guo,

Zhu

et al. 2024

Lipids Health Dis

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Background Frailty is a dynamic geriatric condition. Limited studies have examined the association of the triglyceride-glucose (TyG) index and its related indicators [TyG index, triglyceride glucose-waist to height ratio (TyG-WHtR), triglyceride glucose-waist circumference (TyG-WC), and triglyceride glucose-body mass index (TyG-BMI)] with frailty, and the potential links among them remain unclear. On the basis of data from the National Health and Nutrition Examination Survey (NHANES), this study investigated the potential relationships of the TyG index and its related indices with frailty. Methods This research included 7,965 participants from NHANES 2003–2018. The relationship of the TyG index and its related indices with frailty was investigated with binary logistic regression analyses, restricted cubic spline (RCS), and receiver operating characteristic (ROC) curve. Potential influences were further investigated through stratified analyses and interaction tests. Results The prevalence of frailty in the participants of this study was 25.59%, with a average frailty index of 0.16 (0.00). In the three regression analysis models, the continuous TyG index and its associated indices were positively associated with frailty. In addition, quartiles of TyG, TyG-WC, TyG-WHtR, and TyG-BMI were significantly associated with increased frailty prevalence in the fully adjusted models (TyG Q4 vs. Q1, OR = 1.58, 95% CI: 1.19, 2.09, P = 0.002; TyG-WC Q4 vs. Q1, OR = 2.40, 95% CI: 1.90, 3.04, P < 0.001; TyG-WHtR Q4 vs. Q1, OR = 2.26, 95% CI: 1.82, 2.81, P < 0.001; TyG- BMI Q4 vs. Q1, OR = 2.16, 95% CI: 1.76, 2.64, P < 0.001). According to RCS analysis, TyG, TyG-WC, TyG-WHtR, and TyG-BMI were linearly and positively associated with frailty. ROC curves revealed that TyG-WHtR (AUC: 0.654) had greater diagnostic value for frailty than TyG (AUC: 0.604), TyG-BMI (AUC: 0.621), and TyG-WC (AUC: 0.629). All of the stratified analyses and interaction tests showed similar results. Conclusions Elevated TyG and its associaed indices are associated with an increased prevalence of frailty. Reasonable control of blood glucose and blood lipids, and avoidance of obesity, may aid in reducing the occurrence of frailty in middle-aged and older adults.

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Section: Discussionmentioning

confidence: 99%

Association of the triglyceride-glucose index and its related parameters with frailty

Yin,

Guo,

Zhu

et al. 2024

Lipids Health Dis

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Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study

Liu,

Zhang,

et al. 2024

Clinical and Experimental Hypertension

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Triglyceride-glucose index as a biomarker to differentiate stroke subtypes: A hospital-based cross-sectional study

Daoussi,

Zemni,

Saad

et al. 2023

Preprint

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Background: A growing body of literature suggests that the triglyceride-glucose (TyG) index is linked to ischemic stroke in several ways. The usefulness of this biomarker to differentiate etiologic stroke subtypes has not been thoroughly studied. We aimed to figure out whether the TyG index differentiates cardioembolic (CE) from non-cardioembolic (NCE) strokes. Methods A cross-sectional hospital-based study of consecutive stroke cases admitted to the University Hospital of Monastir in Tunisia from January 2018 to December 2022. The TyG index was calculated through the natural logarithm (Ln) of the product of triglyceride and glucose fasting levels. A binary logistic regression was performed to analyze the association between the TyG index and the studied stroke subtypes. We plotted the receiver operating characteristic curve (ROC curve) to determine the best cutoff point for the TyG index in differentiating between CE and NCE stroke subtypes. Results: We included 320 patients (mean age: 64.2 ±11.1 years; 65.3% males). The TyG index values were independently associated with the NCE subtype (OR=2.38; 95% CI=1.52-3.73; p<0.001) when analyzed as a continuous data variable. Logistic regression of quartile distribution showed that the probability of developing a NCE stroke increased proportionally with the TyG index quartiles. The ROC curve showed an area under the curve of 0.636 (95% CI=0.565-0.707; p<0.001) with a cutoff of 8.8 (sensitivity = 68.8%, specificity = 57%). Conclusion: High levels of the TyG index are associated with a higher prevalence of NCE stroke while low values are associated with CE strokes. Thus, the TyG index can be a useful biomarker in the differentiation between CE and NCE stroke subtypes.

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Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional study

Cited by 7 publications

References 38 publications

Association of the triglyceride-glucose index and its related parameters with frailty

Association of the triglyceride-glucose index and its related parameters with frailty

Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study

Triglyceride-glucose index as a biomarker to differentiate stroke subtypes: A hospital-based cross-sectional study

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