Association between triglyceride-glucose index and worsening renal function in the elderly

Abstract

BackgroundTriglyceride-glucose (TyG) index is a simple marker of insulin resistance. However, insufficient data is available on whether the TyG index is associated with worsening renal function (WRF) in the elderly. Therefore, this study was designed to explore the association between the TyG index and WRF based on a community elderly cohort.MethodsIn this study, 7,822 elderly (aged ≥ 65 years) adults from southern China were enrolled and divided into four groups according to the TyG index quartiles. The primary endpoint was incident chronic kidney disease (CKD), defined as incident estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. Additional endpoints included a decline in eGFR of 30% and 40% during the follow-up period.ResultsDuring the median 2.04 year follow-up period, 1,541 (19.7%) participants developed CKD. After adjusting for confounding factors, multivariable Cox regression models revealed significant associations between TyG index and incident CKD (HR per SD increase, 1.21; 95% CI: 1.14–1.29), a decline in eGFR of 30% (HR per SD increase, 1.38; 95% CI: 1.26–1.50), and decline in eGFR of 40% (HR per SD increase, 1.42; 95% CI: 1.24–1.63). Furthermore, compared with those in Q1, participants in Q4 demonstrated a higher risk of developing CKD (HR, 1.59; 95% CI: 1.35–1.88). These positive associations remained consistent across different subgroup populations.ConclusionOur study suggests a positive and independent association between the TyG index and WRF in the elderly.

Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study

“…Proteinuria was particularly associated with high TyG index in RHF patients [17] . Li et al found that the TyG index showed a positive correlation with the kidney injury in middle-aged and elderly people with WRF [18] . Qin et al [8] found that high TyG levels were positively related to the incidence of contrast-induced acute kidney injury (CI-AKI) only in diabetic patients.…”

Association of dynamic change of triglyceride-glucose index during hospital stay with all-cause mortality in critically ill patients: a retrospective cohort study from MIMIC IV2.0

“…This outcome could not be fully explained by reverse causality [ 38 ] and may partly attribute to another two reasons: firstly, IR plays a more important role in metabolic disease-induced CKD by causing hyperglycemia and later low-grade inflammation and fibrosis. Compare with the general population [ 39 ], TyG index might represent different pathophysiological states in critically ill individuals, secondly, monitoring TyG index dynamic change during hospital stay may more accurately reflect the development of kidney disease. Just recording the baseline TyG index at admission is not enough.…”

Association between the Triglyceride Glucose Index and All-Cause Mortality in Critically Ill Patients with Acute Kidney Injury

“…The TyG index serves as a surrogate marker for IR, and previous studies have demonstrated its application in predicting the incidence and progression of various kidney diseases including diabetic nephropathy [ 9 ], aging nephropathy [ 15 ], and so on. Nonetheless, there is limited evidence regarding the role of TyG index in AKI.…”

“…Previous cross-sectional studies have shown that a high TyG index is strongly associated with proteinuria and decreased kidney function [ 14 ]. Cohort studies have also revealed that TyG index can effectively predict the occurrence and development of chronic kidney diseases including diabetic nephropathy [ 9 ] and aging nephropathy [ 15 ]. However, the role of TyG index in AKI remains poorly understood.…”