Association between triglyceride glucose index and sleep disorders: results from the NHANES 2005–2008

Pei, Heng; Li, Shuyu; Su, Xin; Lü, Yangyang; Wang, Zhijun; Wu, Shouling

doi:10.1186/s12888-022-04434-9

Cited by 12 publications

(14 citation statements)

References 32 publications

(33 reference statements)

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“… 21 , 22 As per our awareness, a recent epidemiological study has investigated the association between TyG index and HI. 14 The findings of this study demonstrated a positive correlation between the TyG index and the risk of HI, indicating a linear association between these two variables. The difference between our research and theirs is that, when defining and calculating HL, conductive and mixed HL were excluded, focusing solely on SNHL for correlation analysis with the TyG index.…”

Section: Discussionsupporting

confidence: 53%

Association Between Triglyceride-Glucose Index and Hearing Threshold Shifts of Adults in the United States: National Health and Nutrition Examination Survey, 2015–2016

Pan,

Chen,

Lin

et al. 2024

JMDH

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Objective Sensorineural Hearing Loss (SNHL) is a representative human sensory impairment, few studies have paid attention to the correlation between the Triglyceride-Glucose (TyG) index and SNHL to date. We conducted this analysis to elucidate the correlation between the TyG index and pure tone hearing thresholds among US adults. Methods Our analysis included 1226 adults (age range: 20 to 69 years old) from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) data. TyG index was scored into three quartiles. Weighted univariate analysis, weighted multivariate linear regression analyses as well as smooth curve fittings evaluated the associations between TyG index and pure tone hearing thresholds. Results In the multiple regression analysis, the second tertile of TyG index was negatively associated with high-frequency hearing thresholds shifts. Furthermore, the non-linear relationships between TyG index and speech-frequency and high-frequency hearing thresholds were identified by smooth curve fittings. After adjusting for potential confounders, the fitted smooth curves were approximately U-shaped, and the two-segment linear regression models were constructed to calculate their inflection points. Conclusion Our findings suggested that the TyG index was nearly U-shaped association with speech-frequency and high-frequency hearing thresholds. These results may imply the importance of maintaining a balanced TyG index in health management.

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Section: Discussionsupporting

confidence: 53%

Association Between Triglyceride-Glucose Index and Hearing Threshold Shifts of Adults in the United States: National Health and Nutrition Examination Survey, 2015–2016

Pan,

Chen,

Lin

et al. 2024

JMDH

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“…The results of this study are consistent with those of a study conducted in Korea showing that an elevated TyG index is associated with an increased risk of developing OSA [ 39 ]. Nevertheless, a separate cross-sectional study suggested that the TyG index may not have a significant association with OSA [ 24 ]. This discrepancy could be attributed to the sample size; specifically, a larger sample size enhances the statistical power of a study, thus increasing its ability to accurately detect effects.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with OSA exhibit significantly greater TyG index levels than healthy controls [ 23 ]. The TyG index may be an independent risk factor for OSA [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Association between the triglyceride glucose index and obstructive sleep apnea and its symptoms: results from the NHANES

Wang,

Shi,

Lin

et al. 2024

Lipids Health Dis

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Background Certain studies have indicated a link between obstructive sleep apnea and insulin resistance in specific populations. To gain more clarity, extensive research involving a broad sample of the overall population is essential. The primary objective of this study was to investigate this correlation by utilizing data from the National Health and Nutrition Examination Survey database. Methods The analysis incorporated data from the National Health and Nutrition Examination Survey database spanning the time periods from 2005 to 2008 and from 2015 to 2018, with a focus on American adults aged 18 years and older after applying weight adjustments. Key variables such as obstructive sleep apnea, triglyceride glucose index, and various confounding factors were considered. A generalized linear logistic regression model was used to investigate the association between obstructive sleep apnea and the triglyceride glucose index, with additional exploration of the consistency of the results through hierarchical analysis and other techniques. Results The study included participants aged between 18 and 90 years, with an average age of 46.75 years. Among the total sample, 50.76% were male. The triglyceride glucose index demonstrated a diagnostic capability for obstructive sleep apnea, with an AUC of 0.701 (95% CI: 0.6619–0.688). According to the fully adjusted model, individuals in the fourth quartile of the triglyceride glucose index showed an increased likelihood of having obstructive sleep apnea compared to those in the first quartile (OR: 1.45; 95% CI: 1.02–2.06; P < 0.05). Subgroup analysis indicated that male sex (OR: 2.09; 95% CI: 1.76–2.45; P < 0.05), younger age (OR: 2.83; 95% CI: 2.02–3.96; P < 0.05), white ethnicity (OR: 2.29; 95% CI: 1.93–2.73; P < 0.05), and obesity (OR: 1.54; 95% CI: 1.28–1.85; P < 0.05) were correlated with an elevated risk of OSA. Conclusions This study demonstrated a strong association between an elevated TG index and OSA. Additionally, the triglyceride glucose index could serve as an independent predictor of obstructive sleep apnea.

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“…The TyG index is proven to be a valuable and reliable IR marker able to assess the CV risk, particularly heart failure, in different populations, from people with diabetes to those with coronary artery diseases [ 19 ]. Indeed, a number of studies assessed the association between TyG and OSA, demonstrating that high TyG levels are related to an increased risk of sleep disorders [ 20 ]. Despite these premises, there is still a need for determination and consolidation of the possible usage of the TyG index in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Triglyceride-glucose index and obstructive sleep apnea: a systematic review and meta-analysis

Behnoush,

Khalaji,

Ghondaghsaz

et al. 2024

Lipids Health Dis

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Background Obstructive sleep apnea (OSA) has a bidirectional association with metabolic syndrome, and insulin resistance (IR). The triglyceride-glucose (TyG) index could be a simply calculated marker of IR in OSA. However, its clinical application appears still limited. Hence, this systematic review and meta-analysis aimed to respond to this question by analyzing all the existing studies showing an association between OSA and the TyG index. Methods Four online databases, including PubMed, Scopus, the Web of Science, and Embase were searched for studies evaluating the TyG index in OSA. After screening and data extraction, a random-effect meta-analysis was performed to compare the TyG index in OSA patients vs. healthy controls by calculating standardized mean difference (SMD) and 95% confidence interval (CI) and pooling the area under the curves (AUCs) for diagnosis of OSA based on this index. Results Ten studies involving 16,726 individuals were included in the current systematic review. Meta-analysis indicated that there was a significantly higher TyG index in patients with OSA, compared with the healthy controls (SMD 0.856, 95% CI 0.579 to 1.132, P < 0.001). Also, TyG had a diagnostic ability for OSA representing a pooled AUC of 0.681 (95% CI 0.627 to 0.735). However, based on the two studies’ findings, no difference between different severities of OSA was observed. Finally, our data showed that the TyG index is a good potential predictor of adverse outcomes in these patients. Conclusion Our study revealed that the TyG index is an easy-to-measure marker of IR for assessing OSA, both in diagnosis and prognosis. Our study supports its implementation in routine practice to help clinicians in decision-making and patient stratification.

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Association between triglyceride glucose index and sleep disorders: results from the NHANES 2005–2008

Cited by 12 publications

References 32 publications

Association Between Triglyceride-Glucose Index and Hearing Threshold Shifts of Adults in the United States: National Health and Nutrition Examination Survey, 2015–2016

Association Between Triglyceride-Glucose Index and Hearing Threshold Shifts of Adults in the United States: National Health and Nutrition Examination Survey, 2015–2016

Association between the triglyceride glucose index and obstructive sleep apnea and its symptoms: results from the NHANES

Triglyceride-glucose index and obstructive sleep apnea: a systematic review and meta-analysis

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