Association between transforming growth factor β1 genetic polymorphism and response to chemoradiotherapy in head and neck squamous cell cancer

Lundberg, Marie; Pajusto, Mervi; Koskinen, Walter J.; Mäkitie, Antti; Aaltonen, Leena‐Maija; Mattila, Petri S.

doi:10.1002/hed.21014

Cited by 9 publications

(15 citation statements)

References 31 publications

(28 reference statements)

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“…This association could not be observed among patients who had no initial chemoradiotherapy but who primarily underwent initial surgery that was planned to be radical [10,11]. These patients had residual tumor immediately or within the next few weeks after the surgery.…”

Section: Discussionmentioning

confidence: 61%

“…Of note is that our previous finding on the association between TGFb1 genotype and survival was restricted to patients who had undergone definitive chemoradiotherapy as the initial planned curative treatment [10,11]. This association could not be observed among patients who had no initial chemoradiotherapy but who primarily underwent initial surgery that was planned to be radical [10,11].…”

Section: Discussionmentioning

confidence: 84%

“…Genotyping of rs1800470 (previously named rs1982073) at TGFb1 was assessed by real-time PCR of peripheral blood DNA as described previously [10].…”

Section: Tgfb1 Genotypingmentioning

confidence: 99%

“…This association was restricted to HNSCC patients who had received chemotherapy with concurrent radiotherapy as the initial planned treatment [10,11]. The polymorphism at SNP rs1800470 results in an exchange of leucin in the 10th N-terminal amino acid within the TGFb1 signal peptide to proline in the variant protein.…”

Section: Introductionmentioning

confidence: 98%

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Transforming growth factor beta 1 genotype and p16 as prognostic factors in head and neck squamous cell carcinoma

Lundberg

Leivo

Saarilahti

et al. 2012

Acta Oto-Laryngologica

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p16 overexpression was associated with an improved disease-free survival (hazard ratio (HR) = 0.39, 95% CI 0.19-0.78), whereas no evident association was observed between EGFR expression and disease-free survival (HR = 0.90, 95% CI 0.68-1.19). Among the 37 patients who had received chemoradiotherapy, TGFβ1 genotype was associated with disease-free (HR = 0.44, 95% CI 0.19-1.02) and overall survival (HR = 0.31, 95% CI 0.12-0.80) independent of tumor p16 expression.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 84%

“…Genotyping of rs1800470 (previously named rs1982073) at TGFb1 was assessed by real-time PCR of peripheral blood DNA as described previously [10].…”

Section: Tgfb1 Genotypingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Transforming growth factor beta 1 genotype and p16 as prognostic factors in head and neck squamous cell carcinoma

Lundberg

Leivo

Saarilahti

et al. 2012

Acta Oto-Laryngologica

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“…Another study showed that TGF-β1 mRNA and TGF-β1 were overexpressed in tumor cells of scirrhous gastric cancer [21]. The TGF-β1 −509 C/T polymorphism have been shown to be associated with breast cancer survival in Chinese population [22,23] and chemoradiotherapy response in 175 Finnish patients with head and neck squamous cancer [24], respectively. A Korean study showed that the variant T genotype is associated with a reduced risk of lung cancer [25].…”

Section: Discussionmentioning

confidence: 99%

Role of transforming growth factor-β1 −509 C/T promoter polymorphism in gastric cancer in south Indian population

et al. 2011

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Gastric cancer is a multifactorial disease with the involvement of both genetic and environmental risk factors. Genetic variation in genes encoding cytokines and their receptors determine the intensity of the inflammatory response, which may contribute to individual differences in the outcome and severity of the disease. Transforming growth factor (TGF-β) signaling pathway plays an important role in the genesis and progression of tumors through regulating cell proliferation and differentiation. A hospital-based case-control study was conducted to investigate whether TGF-β1 -509 C/T polymorphism can modify the risk of gastric cancer. Seventy endoscopically and histopathologically confirmed gastric cancer patients and 100 age and sex-matched healthy controls were enrolled in the case-control study. TGF-β1 -509 C/T gene polymorphism was carried out by amplification refractory mutation system polymerase chain reaction (ARMS-PCR) method followed by agarose gel electrophoresis. Statistical analysis was applied to test for the significance of the results. The distribution of TGF-β1 genotypes at -509 C/T were CC 37.14%, CT 50%, and TT 12.86% in gastric cancer patients and CC 52%, CT 42%, and TT 6% in control subjects. The allelic frequencies of C and T were 0.621 and 0.379 in gastric cancer patients and 0.73 and 0.27 in control subjects, respectively. Our study imply that T allele of TGF-β1 -509 C/T genotypes may be a risk factor of genetic susceptibility to gastric cancer in south Indian population.

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TGFβ1 genetic polymorphism is associated with survival in head and neck squamous cell carcinoma independent of the severity of chemoradiotherapy induced mucositis

et al. 2010

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Association between transforming growth factor β1 genetic polymorphism and response to chemoradiotherapy in head and neck squamous cell cancer

Abstract: Genetic polymorphism of the TGFB1 signal sequence is associated with the response to chemoradiotherapy. TGF-beta1 may sensitize cancer stem cells to chemoradiotherapy.

Cited by 9 publications

References 31 publications

Transforming growth factor beta 1 genotype and p16 as prognostic factors in head and neck squamous cell carcinoma

Transforming growth factor beta 1 genotype and p16 as prognostic factors in head and neck squamous cell carcinoma

Role of transforming growth factor-β1 −509 C/T promoter polymorphism in gastric cancer in south Indian population

TGFβ1 genetic polymorphism is associated with survival in head and neck squamous cell carcinoma independent of the severity of chemoradiotherapy induced mucositis

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