Association between total plasma homocysteine level and cognitive functions in elderly Egyptian subjects

Allam, Mahmoud; Fahmy, Ebtesam Mohamed; Elatti, Sahar Abd; Amer, Hanan; Abokrysha, Noha T.; ELSawy, E.E.T.

doi:10.1016/j.jns.2013.06.023

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…From these, 17 identified significant associations between the plasma Hcy concentrations and cognitive scores. A negative association between the MMSE scores and plasma Hcy levels was found in five studies (99)(100)(101)(102)(103). Furthermore, two more studies found a significant relationship under special conditions, including people over 60 years (104) and in subjects who were Apo E-ε4 carriers (105).…”

Section: General Populationmentioning

confidence: 90%

Homocysteine and cognition: A systematic review of 111 studies

Setién-Suero

Suárez-Pinilla

et al. 2016

Neuroscience & Biobehavioral Reviews

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Section: General Populationmentioning

confidence: 90%

Homocysteine and cognition: A systematic review of 111 studies

Setién-Suero

Suárez-Pinilla

et al. 2016

Neuroscience & Biobehavioral Reviews

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“…Indeed, a review by Smith (41) some years ago reported that 90 out of 100 published cross-sectional and prospective studies showed a link between elevated homocysteine and/or low B-vitamins concentrations with cognitive dysfunction. Most of these studies have focused on elevated plasma homocysteine concentrations (42)(43)(44)(45)(46) , and/or a combination of suboptimal status of folate and vitamin B 12 (47)(48)(49)(50)(51)(52)(53)(54) and to a much lesser extent on vitamin B 6 ( 55,56) . To the authors' knowledge, no published study thus far has focused on riboflavin alone as a potential contributor to cognitive health.…”

Section: Evidence Linking B-vitamins With Brain Health In Ageingmentioning

confidence: 99%

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

et al. 2014

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Nutrition plays a fundamental role in supporting the structural and functional development of the human brain from conception, throughout early infancy and extending into later life. A growing body of evidence suggests that folate and the metabolically related B-vitamins are essential for brain health across all age groups, owing to their specific roles in C 1 metabolism and particularly in the production of S-adenosylmethionine, a universal methyl donor essential for the production of neurotransmitters. Emerging, though not entirely consistent, evidence suggests that maternal folate status throughout pregnancy may influence neurodevelopment and behaviour of the offspring. Furthermore optimal B-vitamin status is associated with better cognitive health in ageing. Of note, a recent clinical trial provided evidence that supplementation with folic acid and related B-vitamins over a 2-year-period reduced global and regional brain atrophy, as measured by MRI scan in older adults. In terms of potential mechanisms, the effects of these B-vitamins on cognitive health may be independent or may be mediated by nutrient-nutrient and/or relevant gene-nutrient interactions. Furthermore, a new area of research suggests that the in utero environment influences health in later life. Folate, an important cofactor in C 1 metabolism, is indirectly involved in DNA methylation, which in turn is considered to be one of the epigenetic mechanisms that may underlie fetal programming and brain development. The present review will explore the evidence that supports a role for folate and the related B-vitamins in brain health across the lifecycle, and potential mechanisms to explain such effects.

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“…Work published later than 2000, which we review below, kept neglecting the issue. Most of the studies exploring the role of HCy levels on the dementias do not report data from multi-domain neuropsychological examination [ 85 , 86 , 88 , 89 , 92 , 93 , 95 , 98 , 99 , 102 , 103 , 104 , 105 , 109 , 112 , 115 , 116 , 117 , 118 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 ]. Typically, authors focus on the general cognitive status of the patient, and thus report data from neuropsychological screening tools, such as the Mini Mental State Examination (MMSE).…”

Section: Homocysteine and Cognitive Functionsmentioning

confidence: 99%

Homocysteine, Cognitive Functions, and Degenerative Dementias: State of the Art

et al. 2022

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There is strong evidence that homocysteine is a risk factor not only for cerebrovascular diseases but also for degenerative dementias. A recent consensus statement renewed the importance and the role of high levels of homocysteine in cognitive decline in several forms of degenerative dementia, such as Alzheimer’s disease. Although the molecular mechanisms by which homocysteine causes cell dysfunction are known, both the impact of homocysteine on specific cognitive functions and the relationship between homocysteine level and non-Alzheimer dementias have been poorly investigated. Most of the studies addressing the impact of hyperhomocysteinemia on dementias have not examined the profile of performance across different cognitive domains, and have only relied on screening tests, which provide a very general and coarse-grained picture of the cognitive status of the patients. Yet, trying to understand whether hyperhomocysteinemia is associated with the impairment of specific cognitive functions would be crucial, as it would be, in parallel, learning whether some brain circuits are particularly susceptible to the damage caused by hyperhomocysteinemia. These steps would allow one to (i) understand the actual role of homocysteine in the pathogenesis of cognitive decline and (ii) improve the diagnostic accuracy, differential diagnosis and prognostic implications. This review is aimed at exploring and revising the state of the art of these two strictly related domains. Suggestions for future research are provided.

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Association between total plasma homocysteine level and cognitive functions in elderly Egyptian subjects

Cited by 7 publications

References 36 publications

Homocysteine and cognition: A systematic review of 111 studies

Homocysteine and cognition: A systematic review of 111 studies

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

Homocysteine, Cognitive Functions, and Degenerative Dementias: State of the Art

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