Association between Topographic Features of the Retinal Nerve Fiber Bundle and Good Visual Acuity in Patients with Glaucoma

Takahashi, Naoki; Omodaka, Kazuko; Kikawa, Tsutomu; Nakazawa, Toru

doi:10.1080/02713683.2021.1912782

Cited by 5 publications

(10 citation statements)

References 35 publications

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“…However, in clinical practice, some patients experience a rapid decrease in BCVA even when not in the advanced stage, contrary to our expectations [11]. Meanwhile, some patients maintain relatively good visual acuity despite being in the severely advanced stage [9,10]. This suggests that factors other than the extent of VF defects may contribute to BCVA.…”

Section: Introductioncontrasting

confidence: 79%

“…Central visual function is closely related to patients' QOL [7]. Thus, maintaining BCVA and central VF is important in glaucoma patients [9]. Either a loss of the central VF or a decrease in the BCVA can significantly affect vision-related QOL [11].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, a previous study performed on the Early Manifest Glaucoma Trial (EMGT) cohort demonstrated that visual acuity is significantly correlated with vision-related QOL, independent of visual field (VF) parameters [6]. The central VF remains relatively intact until the severely advanced stage of the disease due to the surplus of retinal ganglion cells in the macular area [9]. However, as the disease progresses, a reduction in best-corrected visual acuity (BCVA) can occur, and this decline can significantly affect the daily life of glaucoma patients.…”

Section: Introductionmentioning

confidence: 91%

“…This suggests that factors other than the extent of VF defects may contribute to BCVA. Takahashi et al [9] showed that damage to the papillomacular bundle, a specific area of the retina, was strongly associated with BCVA in glaucoma. It has recently been demonstrated that macular vascular density of the deep layer is independently associated with central visual function in glaucoma patients [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated with Visual Acuity in Advanced Glaucoma

Kim

Sung

Park

2023

JCM

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This study aimed to comprehensively analyze various parameters in advanced glaucoma patients to identify the factors that can affect best-corrected visual acuity (BCVA) in advanced glaucoma. This cross-sectional retrospective study included 113 patients (mean age, 61.66 ± 13.26 years; males, 67) who had advanced glaucomatous damage (113 eyes; mean BCVA, 0.18 ± 0.38 logMAR; mean deviation of 30-2 visual field [VF], −19.08 ± 6.23 dB). Peripapillary retinal nerve fiber layer (RNFL) and total and segmented macular thickness (RNFL, ganglion cell layer (GCL), and inner plexiform layer (GCL)) were measured using Spectralis optical coherence tomography (OCT). Correlations between BCVA and OCT parameters or 30-2 VF parameters were assessed using Pearson correlation analysis. Multivariate regression analysis was performed to determine the factors associated with BCVA in advanced glaucoma patients. Peripapillary RNFL thickness, subfoveal choroidal thickness, and global macular RNFL, GCL, IPL, and total thickness were found to be significantly correlated with BCVA and central visual function. Multivariate analysis showed a significant correlation between subfoveal choroidal thickness and BCVA. In addition, central VF mean sensitivity, especially inferior hemifield, showed a significant relationship with BCVA. In conclusion, subfoveal choroidal thickness and central VF sensitivity, especially the inferior hemifield area, are factors that affect BCVA in advanced glaucoma.

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Section: Introductioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Factors Associated with Visual Acuity in Advanced Glaucoma

Kim

Sung

Park

2023

JCM

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“…We previously reported that OCT measurements of the papillomacular nerve fiber bundle (PMB), which is located between the optic disc and the macula, are useful to assess visual acuity (VA) in patients with glaucoma. 10 – 12 OCT is a powerful tool for the detection of early glaucoma, including preperimetric glaucoma, and assessment of its progression. 13 …”

Section: Introductionmentioning

confidence: 99%