Association between tooth loss and hypertension: A systematic review and meta-analysis

Xu, Kehui; Yu, Weiwei; Li, Yuanyuan; Li, Yutao; Wan, Qianqian; Chen, Li; Dong, Yi; Tay, Franklin R.; L, Niu

doi:10.1016/j.jdent.2022.104178

Cited by 24 publications

(15 citation statements)

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“…Descriptive statistics were calculated including percentages and numbers for categorical variables and means and standard deviations for continuous variables. The normality of data was evaluated by inflammation, microbial dysbiosis, and altered immune response [4,9]. In addition, periodontal diseases can also affect the pathogenesis and course of various systemic diseases by triggering a series of chronic inflammatory events [3].…”

Section: Discussionmentioning

confidence: 99%

“…Studies have reported an association between periodontal disease and a wide range of systemic diseases including hypertension [9] (HT), rheumatoid arthritis [4], cardiovascular disorders [5] (CVD), diabetes mellitus [2], and respiratory infections [4]. The possible biologic mechanisms mediating the link between periodontal and systemic diseases include systemic level (𝛽 = 0.95), the number of predictors (n = 16), and the probability level (𝛼 = 0.05) indicated that the minimum sample size needed in the present study was 204 participants.…”

Section: Introductionmentioning

confidence: 99%

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Self-Reported Systemic Diseases and Periodontal Status: A Cross-Sectional Study from Turkey

Özlem¹,

Vatankha²

2023

Int J Oral Dent Health

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Background: Individuals applying for periodontal treatment often have systemic diseases that can adversely affect the periodontal disease course and treatment response. Objectives: To determine the prevalence and types of systemic disease in patients referred for periodontal treatment living in Turkey, and to investigate the association between systemic disease and periodontal status, according to the new classification of periodontal disease (2017). Methods: A total of 800 randomly selected dental files were evaluated among patients who had attended the periodontology department of a university hospital between January 2021 and January 2022. Demographic data (age and gender), self-reported medical history, smoking habits, daily tooth-brushing frequency, periodontal status, and the number of missing teeth were recorded. Full-mouth periodontal examinations were undertaken, and the patients were classified according to the American Association of Periodontology/European Federation of Periodontology 2017 case definitions. Results: The prevalence of systemic disease was 48% among the study participants. Hypertension (HT), diabetes, and cardiovascular diseases (CVD) were the most common systemic diseases identified. Periodontitis was present in 32% of the study population. When periodontitis patients were classified according to their stages; 42% had severe (stageIII\IV) periodontitis, 35% moderate (stage II), and 23% mild (stage I). The prevalence of systemic disease increased according to the severity of periodontal disease (p = 0.000). A significant correlation was also present between the presence of systemic disease and missing teeth (r = 0.120, p = 0.001). On logistic regression analysis, self-reported diabetes (OR = 3.12, 95% CI: 1.90-5.12), HT (OR = 2.49, 95% CI: 1.68-3.68) and CVD (OR = 1.73, 95% CI: 1.01-2.96), age (OR = 1.05, 95% CI: 1.03-1.06), low tooth brushing habits (OR = 2.63, 95% CI: 1.81-3.83) and tobacco use (OR = 1.92, 95% CI: 1.33-2.78) were identified as significant predictors of periodontitis. Conclusions:The present study results suggest an association between self-reported systemic diseases, as well as tobacco use, and periodontal disease severity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Self-Reported Systemic Diseases and Periodontal Status: A Cross-Sectional Study from Turkey

Özlem¹,

Vatankha²

2023

Int J Oral Dent Health

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“…Periodontitis reportedly increases the risk of cardiovascular and several vascular diseases [ 21 , 22 ]. Tooth loss, an indicator of poor oral health, is positively correlated with an increased risk of hypertension [ 23 ], stroke [ 24 ], and increased levels of thrombotic variables [ 25 ] which are associated with thrombus formation. According to a previous cross-sectional study, a higher prevalence of periodontitis was detected in patients with VTE than in healthy participants, suggesting a potential association between periodontitis and VTE [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Improved Oral Health Status Is Associated with a Lower Risk of Venous Thromboembolism: A Nationwide Cohort Study

Park

Kim

Song

2022

JPM

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Oral health is reportedly associated with several systemic diseases, particularly cardiovascular diseases, through systemic inflammatory and thrombotic mechanisms. This study aimed to investigate the association between oral health status, oral hygiene behavior, and venous thromboembolism (VTE) in a nationwide, population-based cohort database in a longitudinal setting. Data of participants who underwent oral health screening by dentists between January and December 2003 (n = 2,415,963) were retrieved from the National Health Insurance Database of the Korean National Health Insurance Service. Periodontitis was identified using claims or oral health screening data. Periodontal pockets and the number of missing teeth were examined by dentists during oral health screenings. Data on oral hygiene behaviors (tooth brushing, dental visits, and dental scaling) were collected. VTE was defined as two or more claims of one of the following ICD-10 codes: deep (I80.2–80.3), pulmonary (I26, I26.0, I26.9), intra-abdominal (I81, I82, I82.2, I82.3), and other (I82.8, I82.9) VTE and concurrent medication (anticoagulants and antiplatelets). VTE was analyzed using the Cox proportional hazard model according to periodontitis, number of missing teeth, tooth brushing frequency, dental visits, and dental scaling. VTE occurred in 39,851 (1.8%) participants within a median of 17.0 (interquartile range 16.3–17.7) years. Periodontitis was associated with VTE (adjusted hazard ratio (HR), 1.2; 95% confidence interval (CI), 1.15–1.28; p < 0.001). An increased number of missing teeth was associated with an increased risk of VTE; the adjusted HR (versus participants without missing teeth) was 1.58 (95% CI, 1.46–1.71; p < 0.001, p for trend < 0.001) for participants with ≥15 missing teeth. Furthermore, tooth brushing ≥3 times a day was negatively correlated with VTE (adjusted HR, 0.67; 95% CI, 0.65–0.69; p < 0.001, p for trend < 0.001). Dental scaling within one year was associated with a significantly lower risk of VTE (adjusted HR, 0.95; 95% CI, 0.93–0.98; p < 0.001). Improved oral hygiene, including tooth brushing and dental scaling, may be associated with a decreased risk of VTE. Periodontitis and an increased number of missing teeth may increase the risk of VTE.

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“…Periodontitis reportedly increased the risk of cardiovascular and several vascular diseases [ 19 , 20 ]. Tooth loss, an indicator of poor oral health, was positively correlated with a higher risk of hypertension [ 21 ] and stroke [ 22 ]. Studies showed that the bacteremia can be caused by periodontitis and poor oral hygiene, [ 23 ] and inflammation induced by oral infection produced pro-inflammatory cytokines [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Better Oral Hygiene Is Associated with a Decreased Risk of Meniere’s Disease: A Nationwide Cohort Study

Park¹,

Kim²,

Lee

et al. 2022

JPM

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To investigate the association of the oral health parameters with Meniere’s disease in a nationwide population-based longitudinal cohort database. The data of the participants who underwent an oral health screening by dentists in 2003 (n = 2,415,963) were retrieved from the National Health Insurance Database of the Korean National Health Insurance Service. The main outcome was the occurrence of Meniere’s disease, defined as two or more claims of the diagnostic code H810 with a previous audiometric examination. The occurrence of Meniere’s disease was analyzed using a Cox proportional hazard model according to the presence of periodontitis and the oral health examination findings, including missing teeth, the frequency of tooth brushing and dental scaling. Overall, the analysis included 2,240,282 participants. During a median follow-up of 16.7 years, Meniere’s disease developed in 112,106 (5.0%) participants. Poor oral health status was characterized by the presence of periodontitis (adjusted hazard ratio [aHR]: 1.18, 95% confidence interval [CI]: 1.14–1.22, p < 0.001) and an increased number of missing teeth (≥15; aHR: 1.25, 95% CI: 1.18–1.32, p < 0.001) was associated with an increased risk of Meniere’s disease. Better oral hygiene behaviors, such as frequent tooth brushing (≥3 per day; aHR: 0.75, 95% CI: 0.73–0.76, p < 0.001) and dental scaling within 1 year (aHR: 0.98, 95% CI: 0.97–0.99, p = 0.003) were negatively associated with the occurrence of Meniere’s disease. The presence of periodontitis and an increased number of missing teeth may augment the risk of the occurrence of Meniere’s disease. However, maintaining good oral hygiene through tooth brushing and dental scaling may be associated with a decreased risk of Meniere’s disease. Further studies should confirm the association between oral health and Meniere’s disease.

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Association between tooth loss and hypertension: A systematic review and meta-analysis

Cited by 24 publications

References 59 publications

Self-Reported Systemic Diseases and Periodontal Status: A Cross-Sectional Study from Turkey

Self-Reported Systemic Diseases and Periodontal Status: A Cross-Sectional Study from Turkey

Improved Oral Health Status Is Associated with a Lower Risk of Venous Thromboembolism: A Nationwide Cohort Study

Better Oral Hygiene Is Associated with a Decreased Risk of Meniere’s Disease: A Nationwide Cohort Study

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