Association between Toll-like receptor gene polymorphisms and risk of Helicobacter pylori infection

Abstract

Background: There were many case-control studies performed the association between TLRs gene polymorphisms and the correlation of Helicobactor pylori infection, these results were inconformity. Therefore, a comprehensive meta-analysis was performed to evaluate the TLRs gene polymorphism and susceptibility to H. pylori infection. Methods: Eligible studies were searched from PubMed, EMBASE, Web of science, Cochrane library, CNKI, CBM, Wan Fang Database and VIP Database, all the databases were searched from inception to December 2020. OR with the corresponding 95% CI were presented as associations between certain TLR gene polymorphism and the risk of H. pylori infection, all the included data will be analyzed with the software of Review Manager 5.2 and STATA 14.2. Results: This study will provide a high-quality evidence to find the TLR gene polymorphisms with H. pylori infection susceptibility. Conclusion: This study will explore which TLR genotype increase the risk of H. pylori infection.

Innate Immunity Crosstalk with Helicobacter pylori: Pattern Recognition Receptors and Cellular Responses

“…Although multiple studies have helped to deepen our understanding of host– H. pylori interactions, more remains to be investigated to explain the different outcomes of H. pylori infection. Recent studies have focused on identification of various PRRs-associated risk alleles [ 82 ], which would provide a better understanding on the risk of infection and degree of severity.…”