Association between Toll-Like Receptor Gene Cluster (TLR6, TLR1, and TLR10) and Prostate Cancer

Chen, Yen‐Ching; Giovannucci, Edward; Kraft, Peter; Lazarus, Ross; Hunter, David J.

doi:10.1158/1055-9965.epi-07-0325

Cited by 36 publications

(39 citation statements)

References 38 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In prostate cancer, early evidence of a role for TLRs in prostate cancer development came from genetic studies of TLR polymorphisms associated with prostate cancer risk. Specifically, multiple studies have shown that single nucleotide polymorphisms (SNPs) in TLR4 and the TLR1-6-10 gene cluster are associated with prostate cancer risk (Chen et al 2005;Zheng et al 2004;Sun et al 2005;Kim et al 2012), although results have varied among cohorts (Chen et al 2007;Shui et al 2012). At the tissue level, TLRs have been reported to be up-regulated by prostate cancer cells as assessed by IHC.…”

Section: Toll-like Receptors (Tlrs)mentioning

confidence: 99%

The Role of Inflammation in Prostate Cancer

Sfanos

Hempel

Marzo

2014

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

In the United States and in "Westernized" countries, the prevalence of both prostate cancer and prostate inflammation is very high, indicating that the two pathologies could be causally related. Indeed, chronic inflammation is now regarded as an "enabling" characteristic of human cancer. Prostate cancer incidence is thought to be mediated in part by genetics, but also by environmental exposures, including the same exposures that may contribute to the development of prostatic inflammation. As our understanding of the role of inflammation in cancer deepens, it is increasingly apparent that "inflammation" as a whole is a complex entity that does not always play a negative role in cancer etiology. In fact, inflammation can play potentially dichotomous (both pro and antitumorigenic) roles depending on the nature and the cellular makeup of the immune response. This chapter will focus on reviewing the current state of knowledge on the role of innate and adaptive immune cells within the prostate tumor microenvironment and their seemingly complex role in prostate cancer in preventing versus promoting initiation and progression of the disease.

show abstract

Section: Toll-like Receptors (Tlrs)mentioning

confidence: 99%

The Role of Inflammation in Prostate Cancer

Sfanos

Hempel

Marzo

2014

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

show abstract

“…Indeed, TLR signaling pathways could promote cancer initiation and progression (19,20). Sequence variants of TLR1, TLR4, TLR6, and TLR10 are associated with increased risk of prostate and gastric cancer (21,22).…”

Section: Introductionmentioning

confidence: 99%

Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance

Cherfils‐Vicini¹,

Platonova²,

Gillard³

et al. 2010

J. Clin. Invest.

194

175

View full text Add to dashboard Cite

Compelling evidence suggests that inflammation, cell survival, and cancer are linked, with a central role played by NF-κB. Recent studies implicate some TLRs in tumor development based on their ability to facilitate tumor growth; however, to our knowledge, involvement of neither TLR7 nor TLR78 has yet been demonstrated. Here we have demonstrated expression of TLR7 and TLR8, the natural receptors for single-stranded RNA, by tumor cells in human lung cancer in situ and in human lung tumor cell lines. Stimulation with TLR7 or TLR8 agonists led to activated NF-κB, upregulated expression of the antiapoptotic protein Bcl-2, increased tumor cell survival, and chemoresistance. Transcriptional analysis performed on human primary lung tumor cells and TLR7-or TLR8-stimulated human lung tumor cell lines revealed a gene expression signature suggestive of chronic stimulation of tumor cells by TLR ligands in situ. Together, these data emphasize that TLR signaling can directly favor tumor development and further suggest that researchers developing anticancer immunotherapy using TLR7 or TLR8 agonists as adjuvants should take into account the expression of these TLRs in lung tumor cells.

show abstract

“…Another study of prostate patients carried out by Cancer Prostate in Sweden observed associations between sequence variants of the TLR6-TLR1-TLR10 gene cluster and the risk of prostate cancer [61] . However, a similar study among American prostate patients found no association between sequence variants of this gene cluster and risk of prostate cancer [62] .…”

Section: Gastritis Gastric Cancer and Prostate Cancermentioning

confidence: 90%

Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases

Corr

O’Neill²

2009

J Innate Immun

View full text Add to dashboard Cite

There has been growing interest in the role of host genetic factors in humans and susceptibility to infectious and inflammatory diseases. Genetic variation in Toll-like receptors (TLRs), key innate immune receptors or their signalling molecules, have been described. Variation in certain TLRs has been linked to disease susceptibility. This genetic variation can result in an altered immune response to pathogenic challenge as well as exorbitant immune activation and inflammation, and thus may influence the pathogenesis or outcome of disease. Examples include variants of TLR4 in sepsis, malaria, inflammatory bowel disease and atherosclerosis; variants in TLR2 in tuberculosis and asthma; a variant in Mal (a key signal for TLR2 and TLR4) in malaria, tuberculosis and systemic lupus erythematosus; and variants in the kinase IRAK4 in pyogenic infections. These associations provide us with a validation for the role of TLRs in human disease, and also suggest possible strategies to limit or boost TLR function in the effort to develop new therapies.

show abstract

Association between Toll-Like Receptor Gene Cluster (TLR6, TLR1, and TLR10) and Prostate Cancer

Cited by 36 publications

References 38 publications

The Role of Inflammation in Prostate Cancer

The Role of Inflammation in Prostate Cancer

Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance

Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases

Contact Info

Product

Resources

About