Association between tobacco use in pregnancy and placenta-associated syndromes: a population-based study

Aliyu, Muktar H.; Lynch, O’Neil; Wilson, Roneé E.; Alio, Amina P.; Kristensen, Sibylle; Marty, Phillip J.; Whiteman, Valerie E.; Salihu, Hamisu M.

doi:10.1007/s00404-010-1447-8

Cited by 66 publications

(48 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Large population-based studies reported that the risk of stillbirth is twice as high in African women, compared to Caucasians [16,18], the risk increases with maternal weight [19,20,21], and it is higher in smokers than non-smokers [22] and in pregnancies conceived by in vitro fertilization and ovulation induction than in spontaneous conceptions [23]. A systematic review examining the causes of stillbirth reported that chronic hypertension is associated with an increased risk with odds ratios of 1.5–2.7 [24].…”

Section: Discussionmentioning

confidence: 99%

Birthweight with Gestation and Maternal Characteristics in Live Births and Stillbirths

et al. 2012

View full text Add to dashboard Cite

Objective: To establish a normal range of birthweight with gestational age (GA) at delivery and examine the contribution of maternal characteristics in defining growth restriction in stillbirths. Methods: In 69,895 normal singleton pregnancies, regression analysis was used to determine the association of birthweight with GA and maternal characteristics. The proportion of 290 stillbirths classified as small for GA depending on inclusion or exclusion of maternal characteristics was determined. Results: In normal pregnancies, there was a polynomial association between birthweight and GA. Birthweight increased with maternal weight, height and parity and was lower in Africans and South Asians than in Caucasians. Birthweight for GA was reduced in antepartum stillbirths (n = 243; p < 0.0001) but not in intrapartum stillbirths (n = 47; p = 0.334). There was no significant difference in the proportion of antepartum stillbirths with birthweight below the 10th percentile when birthweight was corrected for GA only compared to correction for GA and maternal characteristics (53.1 vs. 54.3%). The birthweight was below the 10th percentile in 71.8% of antepartum stillbirths at <32 weeks’ gestation, in 47.2% at 33–36 weeks and in 31.5% at ≥37 weeks. Conclusion: Correction of birthweight for maternal characteristics does not alter the proportion of stillbirths that are small for GA.

show abstract

Section: Discussionmentioning

confidence: 99%

Birthweight with Gestation and Maternal Characteristics in Live Births and Stillbirths

et al. 2012

View full text Add to dashboard Cite

show abstract

“…It was considered whether adjusted ORs for preterm birth, stillbirth, placental abruption and SGA were consistent with findings from other Australian and international population-based studies that used routinely collected data sources or longitudinal cohort data. 1,[42][43][44][45][46][47][48] All analyses were carried out in SAS version 9.3. Ethical approval for this study was granted by the NSW Population and Health Services Research Ethics Committee.…”

Section: Impact Of Enhanced Identificationmentioning

confidence: 99%

Linking birth records to hospital admission records enhances the identification of women who smoke during pregnancy

Tran

Roberts

Havard

et al. 2014

Australian and New Zealand Journal of Public Health

View full text Add to dashboard Cite

Objective: Birth records and hospital admission records are valuable for research on maternal smoking, but individually are known to under-estimate smokers. This study investigated the extent to which combining data from these records enhances the identification of pregnant smokers, and whether this affects research findings such as estimates of maternal smoking prevalence and risk of adverse pregnancy outcomes associated with smoking. Methods:A total of 846,039 birth records in New South Wales, Australia, (2001Australia, ( -2010 were linked to hospital admission records (delivery and antenatal). Algorithm 1 combined data from birth and delivery admission records, whereas algorithm 2 combined data from birth record, delivery and antenatal admission records. Associations between smoking and placental abruption, preterm birth, stillbirth, and low birthweight were assessed using multivariable logistic regression.Results: Algorithm 1 identified 127,612 smokers (smoking prevalence 15.1%), which was a 9.6% and 54.6% increase over the unenhanced identification from birth records alone (prevalence 13.8%), and delivery admission records alone (prevalence 9.8%), respectively. Algorithm 2 identified a further 2,408 smokers from antenatal admission records. The enhancement varied by maternal socio-demographic characteristics (age, marital status, country of birth, socioeconomic status); obstetric factors (multi-fetal pregnancy, diabetes, hypertension); and maternity hospital. Enhanced and unenhanced identification methods yielded similar odds ratios for placental abruption, preterm birth, stillbirth and low birthweight. Conclusions:Use of linked data improved the identification of pregnant smokers. Studies relying on a single data source should adjust for the under-ascertainment of smokers among certain obstetric populations.

show abstract

“…Functionally, these modifications appear to alter placental blood flow [10], and disturb progesterone production [11], estrogen metabolism [12], amino acid transport [13], as well as the activity of drug-metabolizing enzymes [14]. It is worth noting that CSE during pregnancy is also associated with increased risks of placenta-associated syndromes [15], such as preterm birth, placenta previa and placental abruption [16,17].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats

Zhao¹,

Fang²,

Yan³

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Cigarette smoke exposure (CSE) during pregnancy is a well-recognized health hazard that causes placental damage. Hydrogen sulfide (H₂S) has been reported to protect multiple organs from injury. However, the protective effects of H₂S have not been tested in the placenta. This study aimed to explore the potential of H₂S in protecting placenta against oxidative injury induced by CSE during pregnancy and the possible underlying mechanisms. Methods: Pregnant SD rats were randomly divided into 4 groups: NaCl, NaHS (a donor of H₂S), CSE and CSE+NaHS. Placental oxidative damage was detected by 8-hydroxy-2-deoxyguanosine (8-OHdG) stain and malondialdehyde (MDA) assay. Placental redox status was assessed by measuring reactive oxygen species (ROS), total antioxidant capacity (T-AOC) and glutathione (GSH) levels, as well as copper/zinc SOD (SOD1), manganese SOD (SOD2), catalase (CAT) and glutathione peroxidase (GPx) activities and expressions. Meanwhile, nuclear factor erythroid 2-related factor 2 (Nrf2) was analyzed by immunohistochemistry, real-time PCR and Western blot. Results: We found that NaHS markedly reduced the elevated levels of 8-OHdG and MDA induced by CSE. Further, NaHS treatment effectively mitigated CSE-induced placental redox imbalance by inhibiting ROS production, restoring T-AOC level, increasing GSH/GSSG ratio, and augmenting SOD1 SOD2, CAT and GPx activities and expressions. More notably, NaHS administration also reversed the aberrant decrease of Nrf2 due to CSE in rat placentas. Conclusion: Our data demonstrate that H₂S can protect against CSE-induced placental oxidative damage probably by alleviating redox imbalance via Nrf2 pathway.

show abstract

Association between tobacco use in pregnancy and placenta-associated syndromes: a population-based study

Abstract: Maternal smoking in pregnancy is a risk factor for the development of placenta-associated syndrome. Smoking cessation interventions in pregnancy should continue to be encouraged in all maternity care settings.

Cited by 66 publications

References 27 publications

Birthweight with Gestation and Maternal Characteristics in Live Births and Stillbirths

Birthweight with Gestation and Maternal Characteristics in Live Births and Stillbirths

Linking birth records to hospital admission records enhances the identification of women who smoke during pregnancy

Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats

Contact Info

Product

Resources

About