Association between TNF-a promoter -308G/A polymorphism and essential hypertension in the Asian population: A meta-analysis

Yao, Yanwen; Chang, Weiwei; Jin, Yuelong

doi:10.1177/1470320317741066

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…For the TNF-α -308G/A polymorphism, it was discovered that the GA and AA genotypes interacted with hypertension and hyperlipidemia to increase the risk of developing IS. The TNF-α -308 GA + AA genotypes were found to be associated with the risk factor of hypertension in the Asian population, which is consistent with the current findings ( 30 ). The TNF-α -308 A allele also appeared to have a higher risk of stroke when patients also had fever ( 56 ) and showed an increased risk of MI when combined with obesity ( 57 ).…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

“…Moreover, no association of the IL-6 -174G/C polymorphism was observed with the expression levels of IL-6 in the plasma of patients with IS and controls ( 29 ). With regard to TNF-α gene, it was found that the TNF -α-308G/A polymorphism was associated with a risk of IS development ( 15 ) and hypertension ( 30 ) in an Asian population. In addition, TNF-α -308 GA genotypes may be protective factors for IS occurrence in East Asian populations ( 31 , 32 ).…”

Section: Introductionmentioning

confidence: 99%

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Promoter polymorphism of TNF‑α (rs1800629) is associated with ischemic stroke susceptibility in a southern Thai population

et al. 2021

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Stroke represents the leading cause of disability and mortality amongst the elderly worldwide. Multiple risk factors, including both genetic and non-genetic components, as well as their interactions, are proposed as etiological factors involved in the development of ischemic stroke (IS). Promoter polymorphisms of the IL-6-174G/C (rs1800795) and TNF-α-308G/A (rs1800629) genes have been considered as predictive risk factors of IS; however, these have not yet been evaluated in a Thai population. The aims of this study were to investigate the association of IL-6-174G/C and TNF-α-308G/A polymorphisms with IS. Genomic DNA from 200 patients with IS and 200 controls were genotyped for IL-6-174G/C and TNF-α-308G/A polymorphisms using TaqMan™ SNP genotyping and quantitative PCR-high resolution melting analysis, respectively. It was found that the TNF-α-308 A allele was significantly associated with an increased risk of IS development compared with the G allele [odds ratio (OR)=2.044; 95% CI=1.154-3.620; P=0.014]. Moreover, the IS risk was significantly higher in the presence of TNF-α-308 GA or AA genotypes compared with that in the presence of GG genotypes with a dominant inheritance (OR=1.971; 95% CI=1.080-3.599; P=0.027). However, there was no association between IL-6-174G/C and the risk of IS development. The interaction study demonstrated that IL-6-174 GG and TNF-α-308 GG genotypes enhanced IS susceptibility when combined with hypertension, hyperlipidemia and alcohol consumption. Hypertensive and hyperlipidemic subjects with the TNF-α-308 GA and AA genotypes were more likely to develop IS compared with those who did not have these two conditions and had the GG genotype. In a matched study design (1:1), the IL-6-174 GC genotype was associated with higher IL-6 levels in the control group. Collectively, the present results highlight the utility of the TNF-α-308G/A polymorphism as a predictive genetic risk factor for development of IS.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Promoter polymorphism of TNF‑α (rs1800629) is associated with ischemic stroke susceptibility in a southern Thai population

et al. 2021

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“…Although the results are inconsistent, many large studies showed some of FTO genotypes significantly increased risks of hypertension ( 45 ). Many other genes, such as MC4R ( 46 – 48 ), TNF-α ( 49 – 51 ), LEP ( LEPR ) ( 52 – 56 ) and β2AR ( 57 , 58 ), were all associated with both obesity and hypertension. However, because of the lack of comparable co-twin studies, the roles of shared genetic factors in the relationship between overweight or obesity and hypertension are still needed to be explored.…”

Section: Discussionmentioning

confidence: 99%

The Roles of Genetic and Early-Life Environmental Factors in the Association Between Overweight or Obesity and Hypertension: A Population-Based Twin Study

et al. 2021

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Aims/HypothesisWe aimed to explore whether and to what extent overweight or obesity could increase the risk of hypertension, and further to estimate the roles of genetic and early-life familial environmental factors in their association.MethodsThis prospective twin study was based on the Chinese National Twin Registry (CNTR), which collected information from self-report questionnaires. We conducted unmatched case-control analysis to examine the association between overweight or obesity and hypertension. And further to explore whether genetics and familiar environments shared within a twin pair, accounted for their association via co-twin matched case-control design. Generalized estimating equation (GEE) models and conditional logistic regressions were used in the unmatched and matched analyses, respectively. Then, we used logistic regressions to test the difference in odds ratios (ORs) between the unmatched and matched analyses. Finally, through bivariate twin model, the roles of genetic and environmental factors in the body mass index (BMI)- hypertension association were estimated.ResultsOverall, we included a total of 30,617 twin individuals, of which 7533 (24.6%) twin participants were overweight or obesity and 757 (2.5%) developed hypertension during a median follow-up time of 4.4 years. In the GEE model, overweight or obesity was associated with a 94% increased risk of hypertension (OR=1.94, 95% confidence interval (CI): 1.64~2.30). In the conditional logistic regression, the multi-adjusted OR was 1.80 (95% CI: 1.18~2.74). The difference in OR between unmatched and matched analyses was significant (P=0.016). Specifically, overweight or obesity was not associated with hypertension risk in the co-twin design when we full controlled genetic and familiar environmental factors (OR=0.89, 95 CI: 0.46~1.72). After controlling for age and sex, we found the positive BMI-hypertension association was mainly explained by a genetic correlation between them (rA= 0.59, 95% CI: 0.44~1.00).Conclusions/InterpretationGenetics and early-life environments shared by participants within a twin pair appear to account for the association between overweight or obesity and hypertension risk.

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“…Examination of TNF-α and IL-10 revealed that TNF-α expression increased and IL-10 expression decreased in the ALI group. As a proinflammatory mediator, TNF-α causes severe damage to pulmonary microvascular endothelial cells and alveolar epithelial cells, causing cell apoptosis, vascular damage, and thrombosis, increasing lung tissue permeability and hypoxia [25,26]. At the same time, TNF-α can promote the release of a variety of inflammatory mediators and further expand the inflammatory response, thereby aggravating lung tissue damage [27,28].…”

Section: Discussionmentioning

confidence: 99%

Keratinocyte Growth Factor‐2 Reduces Inflammatory Response to Acute Lung Injury Induced by Oleic Acid in Rats by Regulating Key Proteins of the Wnt/β‐Catenin Signaling Pathway

Shao

Chen

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Reducing inflammation can effectively relieve acute lung injury (ALI). Objective. To test whether keratinocyte growth factor-2 (KGF-2) can reduce oleic acid-induced inflammation in ALI of rats and explore its possible mechanism. Methods. 45 Sprague-Dawley rats were randomly divided into control group, ALI group, and ALI + KGF-2 group. The animal model of acute lung injury was established by injecting 0.1 mL/kg oleic acid into the tail vein of rats. Rats in the control group were injected with equal volume of normal saline (NS). Each group needs pretreatment 72 hours before the preparation of the acute lung injury model. The control group and ALI group were instilled with 5 ml/kg NS through the airway, and the same amount of KGF-2 was instilled in the ALI + KGF-2 group. It takes 8 hours to successfully prepare the ALI model. Observe the pathological changes of lung tissue through light microscopy, ultrastructural changes through electron microscopy, and the lung wettability/dry weight (w/d) ratio and lung permeability index (LPI). By detecting changes in inflammatory factors in lung tissue and changes in the number of BALF cells, the changes in inflammation in each group were observed. The expressions of Wnt5a, β-catenin, and APC in lung tissue were detected by immunohistochemistry and Western blot. The changes of key proteins in Wnt/β-catenin signaling pathway in the lung tissue of each group were observed. Result. Compared with the ALI group, after KGF-2 pretreatment, the degree of lung injury was reduced, the expression of inflammatory factors was reduced, and the number of red blood cells and white blood cells in BALF was reduced. It can also be observed that the expression of Wnt5a, β-catenin, and APC, a key protein in the Wnt/β-catenin signaling pathway, is reduced. The analysis showed that the number of inflammatory factors, red blood cells, and white blood cells in BALF was positively correlated with the expression of Wnt5a, β-catenin, and APC. Conclusion. KGF-2 may reduce the inflammatory response in ALI induced by oleic acid by regulating key proteins in the Wnt/β-catenin signaling pathway.

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Association between TNF-a promoter -308G/A polymorphism and essential hypertension in the Asian population: A meta-analysis

Cited by 10 publications

References 24 publications

Promoter polymorphism of TNF‑α (rs1800629) is associated with ischemic stroke susceptibility in a southern Thai population

Promoter polymorphism of TNF‑α (rs1800629) is associated with ischemic stroke susceptibility in a southern Thai population

The Roles of Genetic and Early-Life Environmental Factors in the Association Between Overweight or Obesity and Hypertension: A Population-Based Twin Study

Keratinocyte Growth Factor‐2 Reduces Inflammatory Response to Acute Lung Injury Induced by Oleic Acid in Rats by Regulating Key Proteins of the Wnt/β‐Catenin Signaling Pathway

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